Dong‐Gun Lee
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View article: Perspectives on Anti-BCMA Bispecific Antibodies use in Multiple Myeloma–Experience from Asian Countries
Perspectives on Anti-BCMA Bispecific Antibodies use in Multiple Myeloma–Experience from Asian Countries Open
The insights gained will contribute to developing strategic frameworks and consensus guidelines that can effectively guide clinicians in optimizing outcomes for myeloma patients in diverse healthcare settings.
View article: Geographically structured genotypes and resistance clustering in Aspergillus fumigatus
Geographically structured genotypes and resistance clustering in Aspergillus fumigatus Open
We analysed 498 global Aspergillus fumigatus isolates using multilocus variable-number tandem-repeat (MLVA) typing to investigate regional clustering, environmental–clinical overlap, and azole resistance patterns. The dataset, including 15…
View article: Identification of a novel ltaS mutation in daptomycin heteroresistant community-acquired methicillin-resistant Staphylococcus aureus ST72 strains in South Korea
Identification of a novel ltaS mutation in daptomycin heteroresistant community-acquired methicillin-resistant Staphylococcus aureus ST72 strains in South Korea Open
Daptomycin has been used globally since 2003, with a corresponding increase in daptomycin nonsusceptible (DNS) Staphylococcus aureus. In South Korea, daptomycin became available in 2020, but emerging resistance has posed early therapeutic …
View article: Epidemiology and Characteristics of Invasive Yeast Infections in Patients with Hematologic Diseases: 12-Year Single-Center Retrospective Cohort Study
Epidemiology and Characteristics of Invasive Yeast Infections in Patients with Hematologic Diseases: 12-Year Single-Center Retrospective Cohort Study Open
Invasive yeast infections (IYIs) remain a significant cause of morbidity and mortality in patients with hematologic diseases. We retrospectively analyzed 193 IYI episodes among 179 patients admitted to a tertiary hematology hospital (2012–…
View article: Pathologically Confirmed Dual Coronavirus Disease 2019-Associated Tracheobronchial Aspergillosis and Pulmonary Mucormycosis in a Non-Endemic Region: A Case Report
Pathologically Confirmed Dual Coronavirus Disease 2019-Associated Tracheobronchial Aspergillosis and Pulmonary Mucormycosis in a Non-Endemic Region: A Case Report Open
Background: Coronavirus disease 2019 (COVID-19) has led to the expansion of the spectrum of invasive fungal infections beyond traditional immunocompromised populations. Although COVID-19-associated pulmonary aspergillosis is increasingly b…
View article: Genomic analysis and pneumococcal population dynamics across PCV implementation in South Korea, 1997-2023.
Genomic analysis and pneumococcal population dynamics across PCV implementation in South Korea, 1997-2023. Open
Streptococcus pneumoniae, a clinically significant pathogen, causes invasive diseases in children and older adults. Pneumococcal conjugate vaccines (PCVs) have substantially reduced the incidence of vaccine serotype (VT) pneumococca…
View article: Effectiveness and Safety of Autologous Virus-Specific T-Cell Therapy for Persistent COVID-19 in People With Immunocompromise: A Clinical Trial Study
Effectiveness and Safety of Autologous Virus-Specific T-Cell Therapy for Persistent COVID-19 in People With Immunocompromise: A Clinical Trial Study Open
In this prospective study (N = 12), autologous virus-specific T cells (auto-VSTs) were successfully manufactured in 10 patients (83.3%). Three received VSTs, achieving viral clearance and symptom resolution without severe adverse events. A…
View article: Genomic investigation of NDM-1 producing Enterobacterales transmission in a South Korean hospital
Genomic investigation of NDM-1 producing Enterobacterales transmission in a South Korean hospital Open
This study highlights the dual roles of clonal spread and plasmid-mediated horizontal gene transfer in the dissemination of blaNDM-1 in hospital settings. The persistence of highly conserved IncX3 plasmids in environmental isola…
View article: Ratio of T-cell Subsets Predicts Prognosis in Triple-Negative Breast Cancer Patients
Ratio of T-cell Subsets Predicts Prognosis in Triple-Negative Breast Cancer Patients Open
Background: Triple-negative breast cancer (TNBC) is an aggressive form of cancer characterized by the absence of estrogen, progesterone, and HER2 receptors. Current therapies are ineffective for long-term control and have side effects. Rec…
View article: Hospital-wide surveillance of central line-associated bloodstream infections in a tertiary hospital in South Korea
Hospital-wide surveillance of central line-associated bloodstream infections in a tertiary hospital in South Korea Open
Objectives: Central Line-Associated Bloodstream Infections (CLABSIs) are associated with prolonged hospitalization, increased healthcare costs. It is important to reduce CLABSI rates through interventions. This study investigated the curre…
View article: Gold nanoparticle resveratrol complex increases apoptosis in KRAS mutant pancreatic cancer cells
Gold nanoparticle resveratrol complex increases apoptosis in KRAS mutant pancreatic cancer cells Open
The KRAS G12D mutation is the most prevalent type of pancreatic cancer and is found in about 35% of patients. Numerous natural chemicals are frequently investigated in cancer treatment to decrease side effects. Resveratrol (RVT) is a polyp…
View article: Genetic relationships of <i>Aspergillus fumigatus</i> in hospital settings during COVID-19
Genetic relationships of <i>Aspergillus fumigatus</i> in hospital settings during COVID-19 Open
The transmission pathways and risks of COVID-19-associated pulmonary aspergillosis (CAPA) remain unclear. This study investigated the genetic relationships of Aspergillus fumigatus isolates from patients with and without COVID-19 and envir…
View article: Rapid Differentiation of False Positives of Galactomannan Related to Contaminated Intravenous Fluids via a Pharmacokinetics Model and Innovative Web-Based Tool
Rapid Differentiation of False Positives of Galactomannan Related to Contaminated Intravenous Fluids via a Pharmacokinetics Model and Innovative Web-Based Tool Open
This study developed a pharmacokinetic model and web-based tool to distinguish true invasive aspergillosis from false positives caused by contaminated fluids. By analyzing galactomannan kinetics, false positives were identified within 24 h…
View article: Mathematical modelling for vaccine efficacy trials during the future epidemics of emerging respiratory infections
Mathematical modelling for vaccine efficacy trials during the future epidemics of emerging respiratory infections Open
Assessing vaccine efficacy (VE) during emerging epidemics is challenging due to unpredictable disease transmission dynamics. We aimed to investigate the impact of vaccine randomized controlled trials (RCTs) timing on estimates of VE and sa…
View article: 219. Robust and Consistent Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine (RSVPreF3 OA) Across Different Age Ranges and Frailty Status in Older Adults
219. Robust and Consistent Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine (RSVPreF3 OA) Across Different Age Ranges and Frailty Status in Older Adults Open
Background In a phase 3 study, the approved RSVPreF3 OA vaccine, administered as a single dose in adults aged ≥ 60 years, has demonstrated high efficacy against RSV disease and was well tolerated with a favorable safety profile. Here we pr…
View article: Controlling the Dissolution Behavior of (Meth)acrylate-Based Photoresist Polymers in Tetramethylammonium Hydroxide by Introducing Adamantyl Groups
Controlling the Dissolution Behavior of (Meth)acrylate-Based Photoresist Polymers in Tetramethylammonium Hydroxide by Introducing Adamantyl Groups Open
(Meth)acrylate polymers are commonly used as photoresist materials in photolithography. However, these polymers encounter the problem of swelling during the development process. To address this, we explored the use of a hydrophobic group t…
View article: How Should Cytomegalovirus Infection Be Managed in Allogeneic Hematopoietic Stem Cell Transplant Recipients? A Clinical Grand Round
How Should Cytomegalovirus Infection Be Managed in Allogeneic Hematopoietic Stem Cell Transplant Recipients? A Clinical Grand Round Open
Cytomegalovirus (CMV) is a significant concern for patients with allogeneic hematopoietic cell transplantation (allo-HCT). CMV management differs between institutions due to the lack of local guidelines. Here, we describe a case of refract…
View article: Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer
Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer Open
The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer (mNSCLC), published in January 2023, was modi…
View article: Longitudinal Comparison of Three T-Cell Assays and Three Antibody Assays Against SARS-CoV-2 Following Homologous mRNA-1273/mRNA-1273/mRNA-1273 and Heterologous ChAdOx1/ChAdOx1/BNT162b2 Vaccination: A Prospective Cohort in Naïve Healthcare Workers
Longitudinal Comparison of Three T-Cell Assays and Three Antibody Assays Against SARS-CoV-2 Following Homologous mRNA-1273/mRNA-1273/mRNA-1273 and Heterologous ChAdOx1/ChAdOx1/BNT162b2 Vaccination: A Prospective Cohort in Naïve Healthcare Workers Open
Background: Cellular and humoral immunity are key to the immune response against SARS-CoV-2, but the comparability and correlation across different assays remain underexplored. This study compares three T-cell and three antibody assays in …
View article: Predicting Immunogenic Epitopes Variation of Envelope 2 Gene Among Chikungunya Virus Clonal Lineages by an In Silico Approach
Predicting Immunogenic Epitopes Variation of Envelope 2 Gene Among Chikungunya Virus Clonal Lineages by an In Silico Approach Open
Chikungunya virus (CHIKV), responsible for a mosquito-borne viral illness, has rapidly spread worldwide, posing a significant global health threat. In this study, we explored the immunogenic variability of CHIKV envelope 2 (E2), a pivotal …
View article: An outbreak of blaKPC−4- and blaVIM−1-producing Klebsiella pneumoniae and Klebsiella variicola at a single hospital in South Korea
An outbreak of blaKPC−4- and blaVIM−1-producing Klebsiella pneumoniae and Klebsiella variicola at a single hospital in South Korea Open
View article: SARS-CoV-2-Specific T-Cell as a Potent Therapeutic Strategy against Immune Evasion of Emerging COVID-19 Variants
SARS-CoV-2-Specific T-Cell as a Potent Therapeutic Strategy against Immune Evasion of Emerging COVID-19 Variants Open
Despite advances in vaccination and therapies for coronavirus disease, challenges remain due to reduced antibody longevity and the emergence of virulent variants like Omicron (BA.1) and its subvariants (BA.1.1, BA.2, BA.3, and BA.5). This …
View article: Burden of Herpes Zoster in Individuals With Chronic Conditions in the Republic of Korea: A Nationwide Population-Based Database Study
Burden of Herpes Zoster in Individuals With Chronic Conditions in the Republic of Korea: A Nationwide Population-Based Database Study Open
Background Chronic conditions (CCs) may increase the risk of herpes zoster (HZ) infection, leading to a greater healthcare burden in these individuals compared to those without CCs. It is therefore clinically important to quantify HZ disea…
View article: A Phase 3 Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine–Experienced Adults 50 Years of Age or Older (STRIDE-6)
A Phase 3 Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine–Experienced Adults 50 Years of Age or Older (STRIDE-6) Open
Background Pneumococcal diseases cause considerable morbidity and mortality in adults. V116 is an investigational 21-valent pneumococcal conjugate vaccine (PCV) specifically designed to protect adults from pneumococcal serotypes responsibl…
View article: Antimicrobial resistance genes harbored in invasive Acinetobacter calcoaceticus-baumannii complex isolated from Korean children during the pre-COVID-19 pandemic periods, 2015–2020
Antimicrobial resistance genes harbored in invasive Acinetobacter calcoaceticus-baumannii complex isolated from Korean children during the pre-COVID-19 pandemic periods, 2015–2020 Open
Background Acinetobacter baumannii (AB) has emerged as one of the most challenging pathogens worldwide, causing invasive infections in the critically ill patients due to their ability to rapidly acquire resistance to antibiotics. This stud…
View article: Impact of an antimicrobial stewardship programme on antibiotic utilization and resistance burden in patients with acute leukaemia: an 11-year longitudinal cohort study using interrupted time-series analysis
Impact of an antimicrobial stewardship programme on antibiotic utilization and resistance burden in patients with acute leukaemia: an 11-year longitudinal cohort study using interrupted time-series analysis Open
Background Antimicrobial resistance (AMR), driven by inappropriate and overuse of antibiotics, poses a significant threat, especially to patients with acute leukaemia. Objectives To evaluate the impact of antimicrobial stewardship programm…
View article: Implementing antimicrobial stewardship: lessons and perspectives from a university-affiliated tertiary hospital in Korea
Implementing antimicrobial stewardship: lessons and perspectives from a university-affiliated tertiary hospital in Korea Open
Antimicrobial stewardship programs (ASPs) can lower antibiotic use, decrease medical expenses, prevent the emergence of resistant bacteria, and enhance treatment for infectious diseases. This study summarizes the stepwise implementation an…
View article: Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea Open
Background/Aims: Since the coronavirus disease 2019 (COVID-19) outbreak, hospitals have implemented infection control measures to minimize the spread of the virus within facilities. This study aimed to investigate the impact of COVID-19 on…
View article: Analytical Performance Evaluation of a Digital Real‐Time <scp>PCR</scp> for Quantifying Major <i><scp>BCR</scp>::<scp>ABL1</scp></i> Transcripts
Analytical Performance Evaluation of a Digital Real‐Time <span>PCR</span> for Quantifying Major <i><span>BCR</span>::<span>ABL1</span></i> Transcripts Open
Background Accurate quantification of the BCR::ABL1 transcripts is essential for measurable residual disease (MRD) monitoring in chronic myeloid leukemia (CML) after tyrosine kinase inhibitor (TKI) treatment. This study evaluated the newly…
View article: The First Case of Pulmonary Mucormycosis Caused by <i>Lichtheimia ornata</i>
The First Case of Pulmonary Mucormycosis Caused by <i>Lichtheimia ornata</i> Open
Jungjun Lee, M.D., Dong-Gun Lee, M.D., Ph.D., Raeseok Lee, M.D., M.P.H., Jae-Ho Yoon, M.D., Ph.D., Kyongmin Sarah Beck, M.D., Ph.D., In Young Yoo, M.D., Ph.D., and Yeon-Joon Park, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/…