Wayne J.G. Hellstrom
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History of Peyronie’s disease: from early descriptions to modern treatments Open
Introduction Peyronie’s disease (PD) is a fibroproliferative disorder of the tunica albuginea characterized by localized plaque formation, penile curvature, and erectile dysfunction, most commonly affecting men between 40 and 70 years of a…
View article: (047) Peyronie’s Xenograft Model Using Patient-Derived Human Plaque to Reconstitute Curvature in Immunocompromised Rats
(047) Peyronie’s Xenograft Model Using Patient-Derived Human Plaque to Reconstitute Curvature in Immunocompromised Rats Open
Introduction Peyronie’s disease (PD) is a connective tissue disorder in which a pathologic fibrotic plaque develops in the tunica albuginea of the corpus cavernosa. Currently employed research models involve injection of profibrotic factor…
Addressing unmet needs for patients with erectile dysfunction: a narrative review of topical therapies Open
Background Treatment of patients with erectile dysfunction (ED) was revolutionized by the development and approval of phosphodiesterase type 5 inhibitors (PDE5is), which have been repeatedly shown to be safe and effective in men with this …
(153) CAN LARGE-LANGUAGE MODELS ACCURATELY DISCERN AI-GENERATED SEXUAL MEDICINE SCIENTIFIC LITERATURE FROM HUMAN GENERATED? Open
Introduction Chat-GPT an iteration of Artificial Intelligence (AI) which utilizes Large-Language Model (LLM) to understand and generate text, has been increasingly employed in scientific literature, healthcare, and education since its rele…
Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches Open
Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male factor contributing to 20–30% of cases. Oxidative stress (OS) is a critical factor in male infertility, disrupting the balance between reactive…
(234) How Age and Obesity Influence Erectile Dysfunction: Evaluation Based Upon Penile Color Duplex Doppler Ultrasound Open
Introduction Color duplex Doppler ultrasound (CDDU) is an objective and reliable diagnostic tool for documenting penile hemodynamics. Objective vascular testing provides a physiologic diagnosis of erectile dysfunction (ED) and helps direct…
(023) Can Artificial Intelligence Generate a Superior Introduction to a Systematic Review? Open
Introduction An iteration of artificial intelligence (AI), large language models (LLMs), such as ChatGPT, have recently gained popularity as a potential educational resource for patients, students, and researchers. LLMs utilize deep learni…
Clomiphene Citrate in the Management of Infertility in Oligospermic Obese Men with Hypogonadism: Retrospective Pilot Study Open
Background and Objectives: Obesity is a significant risk factor for hypogonadism and infertility that is further associated with reduced semen quality. The aim of this study is to evaluate the effect of clomiphene citrate (CC), prescribed …
Molecular mechanisms of penile traction for penile rehabilitation in a bilateral cavernous nerve crush injury rat model Open
Findings from this animal study suggest that PTT has the potential to mitigate penile retraction after RP. While more studies are needed to determine the effect of PTT on preservation of EF, the increased eNOS expression observed in the Tr…
Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies Open
Results suggest that once daily filgotinib 200 mg for 13 weeks has no measurable impact on semen parameters or sex hormones in men with active IBD or inflammatory rheumatic diseases.
(301) Evidenced-Based Analysis of the Top 50 Testosterone Booster Supplements on Amazon Marketplace Open
Introduction As the population ages, the prevalence of age-related hypogonadism is expected to rise. Demand for testosterone replacement therapy (TRT) has increased, as evidenced by revenue from T prescriptions in the world increasing from…
(107) Uncovering the Role of Mast Cell Dysfunction in the Pathophysiology of Vulvodynia, Post-orgasmic Illness Syndrome, and Interstitial Cystitis Open
Introduction Certain sexual disorders are under-reported, under-researched, and rarely discussed. Many patients have suffered from ailments such as vulvodynia, a subset of vulvodynia called vestibulodynia, post-orgasmic illness syndrome (P…
(165) Role of Penile Veno-occlusive Dysfunction in Peyronie’s Disease Patients with Erectile Dysfunction Open
Introduction The incidence of Peyronie's disease (PD) is 4% in the U.S. male population. Many PD patients also suffer from erectile dysfunction (ED). The etiology of ED incidence in PD men is not known, although veno-occlusive dysfunction …
(291) Long-term Assessment of the Safety and Efficacy of the Mini-Jupette Sling: 5-year Follow-up of the Original Series Open
Introduction Climacturia has been reported in up to 64% of patients following radical prostatectomy (RP). In 2017, a prospective multicenter, multinational, investigational pilot study was conducted examining outcomes using a novel surgica…
(161) Xiaflex Nonresponders Show Alteration in Penile Measurements: Post-Market Analysis of Predictors for Treatment Success Open
Introduction The IMPRESS trial revealed that intralesional collagenase clostridium histolyticum, Xiaflex, is safe and efficacious for treating the physical and subjective effects of Peyronie’s Disease (PD). However, little is known about t…
Long-term assessment of the safety and effectivity of the mini-jupette sling: 5-year follow-up of the original series Open
The mini-jupette sling appears to be a safe and effective procedure with durable improvements in SUI and climacturia at 5 years of follow-up.
View article: Patients with adult-acquired buried penis and their surgical management: a single-center study
Patients with adult-acquired buried penis and their surgical management: a single-center study Open
Adult-acquired buried penis (AABP) is a condition in which the suprapubic fat (the escutcheon) conceals the penis. The etiologies of AABP include obesity, pelvic lymphedema, lichen sclerosis, and scar contraction following a circumcision. …
Residual penile curvature correction by modeling during penile prosthesis implantation in Peyronie’s disease patients Open
With the advent of new surgical techniques to treat Peyronie’s disease with concomitant erectile dysfunction, there remains a question of whether manual modeling, an older technique, still has a place in the treatment algorithm within peni…
Testosterone Therapy in Men on Active Surveillance Open
In recent decades, although prostate cancer (PCa) mortality has dramatically decreased, addressing the quality of life for PCa survivors has become an area of great interest. This is especially important among men who are enrolled in activ…
Association between Seminal Oxidation-Reduction Potential and Sperm DNA Fragmentation—A Meta-Analysis Open
Seminal oxidative stress and sperm DNA damage are potential etiologies of male factor infertility. The present study aims to evaluate the relationship between oxidation-reduction potential (ORP), a measure of oxidative stress, and sperm DN…
View article: Metabolic Syndrome and Erectile Dysfunction
Metabolic Syndrome and Erectile Dysfunction Open
Metabolic syndrome (MetS) is considered a risk factor for erectile dysfunction (ED), and ED is almost three times more prevalent in men with MetS. Vascular pathologies are a significant factor for the development of ED, and many experts su…
PD20-02 PENILE TRACTION THERAPY INCREASES STRETCHED PENILE LENGTH AND ENDOTHELIAL NITRIC OXIDE SYNTHASE EXPRESSION IN A BILATERAL CAVERNOUS NERVE CRUSH INJURY RAT MODEL Open
You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy I (PD20)1 Sep 2021PD20-02 PENILE TRACTION THERAPY INCREASES STRETCHED PENILE LENGTH AND ENDOTHELIAL NITRIC OXIDE SYNTHASE EXPRESSION IN …
PD62-06 EXPLORING THE MICRORNA EXPRESSION PROFILE OF PEYRONIES DISEASE PLAQUES Open
You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology (PD62)1 Sep 2021PD62-06 EXPLORING THE MICRORNA EXPRESSION PROFILE OF PEYRONIES DISEASE PLAQUES Joseph Kim, Jaideep Toor, Hogyung Kim, Suresh Sik…
Tips and tricks in the management of inflatable penile prosthesis infection: A review Open
: A greater success in IPP implantation can be attributed to appropriate prophylaxis, field sterilisation, and surgical technique. For those implants that do become infected, often erectile function can be preserved by immediate antibiotic…
Methods for managing erectile function in cis- and trans-male patients after neophallus reconstruction Open
Understanding the methods and rationale for managing erectile function in cis- and trans-male patients after neophallus reconstruction is of clinical value to the practicing urologists who encounter such patients. We describe a brief overv…