Harry W. Herr
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View article: Neoadjuvant Chemotherapy for High-risk Localized Upper Tract Urothelial Carcinoma: Final Long-term Outcomes from a Phase 2 Clinical Trial and an Expanded Cohort
Neoadjuvant Chemotherapy for High-risk Localized Upper Tract Urothelial Carcinoma: Final Long-term Outcomes from a Phase 2 Clinical Trial and an Expanded Cohort Open
We previously reported results from a prospective, multicenter, phase 2 trial that demonstrated a pathologic response rate (<ypT2N0) of 63% among 57 patients with high-risk nonmetastatic upper tract urothelial carcinoma (UTUC) treated with…
View article: Bladder Cancer, Version 3.2024
Bladder Cancer, Version 3.2024 Open
Bladder cancer, the sixth most common cancer in the United States, is most commonly of the urothelial carcinoma histologic subtype. The clinical spectrum of bladder cancer is divided into 3 categories that differ in prognosis, management, …
View article: Natural History and Genomic Landscape of Chemotherapy-Resistant Muscle-Invasive Bladder Cancer
Natural History and Genomic Landscape of Chemotherapy-Resistant Muscle-Invasive Bladder Cancer Open
PURPOSE Patients with residual invasive bladder cancer after neoadjuvant chemotherapy (NAC) and radical cystectomy have a poor prognosis. Data on adjuvant therapy for these patients are conflicting. We sought to evaluate the natural histor…
View article: Response to 2 Induction Courses of Bacillus Calmette-Guèrin Therapy Among Patients With High-Risk Non–Muscle-Invasive Bladder Cancer
Response to 2 Induction Courses of Bacillus Calmette-Guèrin Therapy Among Patients With High-Risk Non–Muscle-Invasive Bladder Cancer Open
Importance With the ongoing bacillus Calmette-Guèrin (BCG) shortage, alternate therapeutic options for patients with high-risk non–muscle-invasive bladder cancer (NMIBC) are needed. Objective To report the 5-year outcomes of a cohort from …
View article: Health-related Quality of Life After Robotic-assisted vs Open Radical Cystectomy: Analysis of a Randomized Trial
Health-related Quality of Life After Robotic-assisted vs Open Radical Cystectomy: Analysis of a Randomized Trial Open
Over a broad range of health-related quality of life domains comparing robotic-assisted radical cystectomy and open radical cystectomy, there are unlikely to be clinically relevant differences in the medium to long term, and therefore heal…
View article: Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma
Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma Open
PURPOSE Neoadjuvant chemotherapy (NAC) has proven survival benefits for patients with invasive urothelial carcinoma of the bladder, yet its role for upper tract urothelial carcinoma (UTUC) remains undefined. We conducted a multicenter, sin…
View article: Hunter H McGuire– Ignominious Legacy of a Confederate Surgeon
Hunter H McGuire– Ignominious Legacy of a Confederate Surgeon Open
Objectives National protests in the wake of the murder of George Floyddemanded that Confederate statues be removed from public view as symbols of slavery and racism. A statue still stands in Richmond, Virginia, dedicated to a Confederate s…
View article: Genitourinary tumors
Genitourinary tumors Open
Memorial Sloan Kettering Cancer Center (MSK) has made many notable contributions to the scientific understanding and care of patients with common urologic cancers. Many of the advances represented paradigm shifts in management and establis…
View article: NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022
NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022 Open
The NCCN Guidelines for Bladder Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with bladder cancer and other urinary tract cancers (upper tract tumors, urothelial carcinoma of the prostat…
View article: Uretero‐enteric stricture outcomes: secondary analysis of a randomised controlled trial comparing open versus robot‐assisted radical cystectomy
Uretero‐enteric stricture outcomes: secondary analysis of a randomised controlled trial comparing open versus robot‐assisted radical cystectomy Open
Objectives To analyse the risk of uretero‐enteric anastomotic stricture in patients randomised to open (ORC) or robot‐assisted radical cystectomy (RARC) with extracorporeal urinary diversion. Patients and Methods We included 118 patients r…
View article: Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype
Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype Open
PURPOSE To compare oncologic outcomes and genomic alteration profiles in patients with bladder and urachal adenocarcinoma, urothelial carcinoma (UC) with glandular differentiation, and UC, not otherwise specified (NOS) undergoing surgical …
View article: Urethral Melanoma – Clinical, Pathological and Molecular Characteristics
Urethral Melanoma – Clinical, Pathological and Molecular Characteristics Open
BACKGROUND: Mucosal melanoma involving the urethra is a rare disease with distinct clinical and molecular characteristics and poor outcomes. Our current knowledge is limited by the small number of reports regarding this disease. OBJECTIVE:…
View article: Neoadjuvant Atezolizumab With Gemcitabine and Cisplatin in Patients With Muscle-Invasive Bladder Cancer: A Multicenter, Single-Arm, Phase II Trial
Neoadjuvant Atezolizumab With Gemcitabine and Cisplatin in Patients With Muscle-Invasive Bladder Cancer: A Multicenter, Single-Arm, Phase II Trial Open
PURPOSE Neoadjuvant gemcitabine and cisplatin (GC) followed by radical cystectomy (RC) is standard for patients with muscle-invasive bladder cancer (MIBC). On the basis of the activity of atezolizumab (A) in metastatic BC, we tested neoadj…
View article: Bullet Babies: The repeating nature of the medical hoax
Bullet Babies: The repeating nature of the medical hoax Open
Introduction: Incredible tales of medical hoaxes associated with virgin births have been recounted through history. Some reports exist of wartime gunshot testicular injuries that caused pregnancy in a second bullet victim. This paper sough…
View article: The First Two Total Cystectomies – A brief history of failed-successes
The First Two Total Cystectomies – A brief history of failed-successes Open
Objectives Radical cystectomy is a complex surgery for bladder cancer which has undergone progressive changes for a century. The originators of the procedure required pioneering innovation and their biographies place the challenges of radi…
View article: Intravesical Bacille Calmette-Guerin (BCG) Eradicates Bacteriuria in Antibiotic-Naïve Bladder Tumor Patients
Intravesical Bacille Calmette-Guerin (BCG) Eradicates Bacteriuria in Antibiotic-Naïve Bladder Tumor Patients Open
Intravesical Mycobacterium bovis bacille Calmette-Guerin (BCG) is standard therapy for high grade noninvasive bladder cancer. BCG induces a robust immune response in the bladder, characterized by cytokine production, inflammation, and recr…
View article: Natural history, response to systemic therapy, and genomic landscape of plasmacytoid urothelial carcinoma
Natural history, response to systemic therapy, and genomic landscape of plasmacytoid urothelial carcinoma Open
Background Plasmacytoid urothelial carcinoma (PUC) is a rare, aggressive histologic variant of urothelial cancer characterised by a diffuse growth pattern and CDH1 mutation. We studied the efficacy of preoperative platinum-based chemothera…
View article: Examining the Accuracy of Self-Reported Smoking-Related Exposure among Recently Diagnosed Nonmuscle Invasive Bladder Cancer Patients
Examining the Accuracy of Self-Reported Smoking-Related Exposure among Recently Diagnosed Nonmuscle Invasive Bladder Cancer Patients Open
Our findings suggest either biochemical verification with cotinine or additional questions about other sources of nicotine are needed to accurately identify nonmuscle invasive bladder cancer patients who have smoking-related exposures. Acc…
View article: Electronic Rapid Fitness Assessment Identifies Factors Associated with Adverse Early Postoperative Outcomes following Radical Cystectomy
Electronic Rapid Fitness Assessment Identifies Factors Associated with Adverse Early Postoperative Outcomes following Radical Cystectomy Open
We demonstrated the feasibility of assessing fitness in patients older than 75 years undergoing radical cystectomy using a novel electronic fitness tool. Physical limitations and overall impairment corresponded to higher intensive care uni…
View article: Goal-directed versus Standard Fluid Therapy to Decrease Ileus after Open Radical Cystectomy
Goal-directed versus Standard Fluid Therapy to Decrease Ileus after Open Radical Cystectomy Open
Background Postoperative ileus is a common complication of intraabdominal surgeries, including radical cystectomy with reported rates as high as 32%. Perioperative fluid administration has been associated with improvement in postoperative …
View article: Primary urethral cancer: treatment patterns and associated outcomes
Primary urethral cancer: treatment patterns and associated outcomes Open
Objectives To evaluate treatment patterns and associated outcomes of patients with urethral cancer. Patients and Methods After obtaining institutional review board approval we identified 165 patients treated for primary urethral cancer bet…
View article: Trends in Management and Outcomes among Patients with Urothelial Carcinoma Undergoing Radical Cystectomy from 1995 to 2015: The Memorial Sloan Kettering Experience
Trends in Management and Outcomes among Patients with Urothelial Carcinoma Undergoing Radical Cystectomy from 1995 to 2015: The Memorial Sloan Kettering Experience Open
During a 21-year period outcomes after radical cystectomy at our institution improved significantly, as the probability of recurrence and cancer specific mortality decreased. Increasing use of neoadjuvant chemotherapy, rising pT0 rates, de…