W. Ivan Morrison
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View article: A locus conferring tolerance to Theileria infection in African cattle
A locus conferring tolerance to Theileria infection in African cattle Open
East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a coh…
View article: Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes
Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes Open
Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently r…
View article: Clinical Evaluation of Corridor Disease in Bos indicus (Boran) Cattle Naturally Infected With Buffalo-Derived Theileria parva
Clinical Evaluation of Corridor Disease in Bos indicus (Boran) Cattle Naturally Infected With Buffalo-Derived Theileria parva Open
Corridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva . Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva , CD has not been extensively studie…
View article: CD4 T Cell Responses to <i>Theileria parva</i> in Immune Cattle Recognize a Diverse Set of Parasite Antigens Presented on the Surface of Infected Lymphoblasts
CD4 T Cell Responses to <i>Theileria parva</i> in Immune Cattle Recognize a Diverse Set of Parasite Antigens Presented on the Surface of Infected Lymphoblasts Open
Parasite-specific CD8 T cell responses play a key role in mediating immunity against Theileria parva in cattle (Bos taurus), and there is evidence that efficient induction of these responses requires CD4 T cell responses. However, informat…
View article: High throughput analysis of <scp>MHC‐I</scp> and <scp>MHC‐DR</scp> diversity of Brazilian cattle populations
High throughput analysis of <span>MHC‐I</span> and <span>MHC‐DR</span> diversity of Brazilian cattle populations Open
The major histocompatibility complex (MHC) contains many genes that play key roles in initiating and regulating immune responses. This includes the polymorphic MHCI and MHCII genes that present epitopes to CD8+ and CD4+ T‐cells, respective…
View article: Hydrophobic Mycobacterial Antigens Elicit Polyfunctional T Cells in Mycobacterium bovis Immunized Cattle: Association With Protection Against Challenge?
Hydrophobic Mycobacterial Antigens Elicit Polyfunctional T Cells in Mycobacterium bovis Immunized Cattle: Association With Protection Against Challenge? Open
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease of cattle with a detrimental impact on food quality and production. Research on bTB vaccines has predominantly been focused on proteinaceous antigens. However, …
View article: Correction for Yang et al., “Granzyme B Is an Essential Mediator in CD8 <sup>+</sup> T Cell Killing of <i>Theileria parva</i> -Infected Cells”
Correction for Yang et al., “Granzyme B Is an Essential Mediator in CD8 <sup>+</sup> T Cell Killing of <i>Theileria parva</i> -Infected Cells” Open
Volume 87, no. 1, e00386-18, 2019, [https://doi.org/10.1128/IAI.00386-18][1]. Page 1: This article was published on 19 December 2018 with a CC BY 4.0 copyright line (“© 2018 Yang et al. This is an open access article distributed under the …
View article: Granzyme B Is an Essential Mediator in CD8 <sup>+</sup> T Cell Killing of <i>Theileria parva</i> -Infected Cells
Granzyme B Is an Essential Mediator in CD8 <sup>+</sup> T Cell Killing of <i>Theileria parva</i> -Infected Cells Open
There is established evidence that cytotoxic CD8 + T cells are important mediators of immunity against the bovine intracellular protozoan parasite Theileria parva . However, the mechanism by which the specific CD8 + T cells kill parasitize…
View article: Granzyme B is an essential mediator in CD8+ T cell killing of<i>Theileria parva</i>-infected cells
Granzyme B is an essential mediator in CD8+ T cell killing of<i>Theileria parva</i>-infected cells Open
There is established evidence that cytotoxic CD8+ T cells are important mediators of immunity against the bovine intracellular protozoan parasite T. parva. However, the mechanism by which the specific CD8+ T cells kill parasitized cells is…
View article: <i>Theileria parva</i>antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines
<i>Theileria parva</i>antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines Open
The extent of sequence diversity among the genes encoding 10 antigens (Tp1–10) known to be recognized by CD8 + T lymphocytes from cattle immune to Theileria parva was analysed. The sequences were derived from parasites in 23 buffalo-derive…
View article: Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells
Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells Open
As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in ca…
View article: Co-infections determine patterns of mortality in a population exposed to parasite infection
Co-infections determine patterns of mortality in a population exposed to parasite infection Open
Highly protective effect of co-infections on mortality due to East Coast fever and consequences for disease epidemiology and control.