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View article: Marked survival gains in patients ≤ 65 years with advanced-stage mantle cell lymphoma: a pooled analysis of six randomized phase III trials, 1996-2020
Marked survival gains in patients ≤ 65 years with advanced-stage mantle cell lymphoma: a pooled analysis of six randomized phase III trials, 1996-2020 Open
Mantle cell lymphoma (MCL) remains a challenging and generally incurable disease. We aimed to evaluate survival trends in advanced-stage MCL over the past three decades, focusing on the impact of evolving first-line therapies. We pooled si…
View article: Mutation profiling in differential diagnosis between <scp>TdT</scp> ‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma
Mutation profiling in differential diagnosis between <span>TdT</span> ‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma Open
Terminal deoxynucleotidyl transferase (TdT) is occasionally expressed in large B‐cell lymphoma (LBCL), and this causes difficulty in differential diagnosis from B‐lymphoblastic leukaemia/lymphoma (B‐ALL/LBL). We reviewed 31 cases of TdT‐po…
View article: Brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone for advanced‐stage Hodgkin lymphoma in older patients
Brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone for advanced‐stage Hodgkin lymphoma in older patients Open
View article: Circulating Tumor DNA in Pediatric Mature B‐Cell Non‐Hodgkin Lymphoma for Genotyping and Minimal Disease Monitoring
Circulating Tumor DNA in Pediatric Mature B‐Cell Non‐Hodgkin Lymphoma for Genotyping and Minimal Disease Monitoring Open
Background Early detection of treatment failure in pediatric patients with mature B‐cell non‐Hodgkin lymphoma (NHL) could improve treatment stratification. Analysis of circulating tumor DNA (ctDNA) has been established as a biomarker in ad…
View article: Comparative <scp>DNA</scp> Methylation Profiling of Human and Murine <scp>ALK</scp>‐Positive B‐Cell Neoplasms
Comparative <span>DNA</span> Methylation Profiling of Human and Murine <span>ALK</span>‐Positive B‐Cell Neoplasms Open
Structural genomic variants leading to anaplastic lymphoma kinase (ALK) gene fusions and aberrant expression of the ALK tyrosine kinase are the hallmark of subtypes of T‐ and B‐lineage neoplasms, namely ALK‐positive anaplastic large lympho…
View article: Extramedullary plasmacytoma in children is a genetically distinct localized neoplasia curable by surgical resection
Extramedullary plasmacytoma in children is a genetically distinct localized neoplasia curable by surgical resection Open
Extramedullary plasmacytomas (EMPs) are exceedingly rare in children and adolescents. We describe clinical, pathological, and molecular features of 13 patients with EMP in this age group (8 males and 5 females; age 3-18 years). EMPs presen…
View article: 28 | OUTCOMES FROM THE PHASE 3 inMIND STUDY OF TAFASITAMAB (TAFA) PLUS LENALIDOMIDE (LEN) AND RITUXIMAB (R) FOR PATIENTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (R/R FL)
28 | OUTCOMES FROM THE PHASE 3 inMIND STUDY OF TAFASITAMAB (TAFA) PLUS LENALIDOMIDE (LEN) AND RITUXIMAB (R) FOR PATIENTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA (R/R FL) Open
View article: 266 | INTEGRATIVE ANALYSIS AND IDENTIFICATION OF A PREDICTIVE EPIGENETIC SIGNATURE IN HIGH‐RISK MANTLE CELL LYMPHOMA: A LYSA STUDY
266 | INTEGRATIVE ANALYSIS AND IDENTIFICATION OF A PREDICTIVE EPIGENETIC SIGNATURE IN HIGH‐RISK MANTLE CELL LYMPHOMA: A LYSA STUDY Open
View article: 137 | IBRUTINIB ADDED TO MCL TREATMENT HAS STRONG IMPACT ON MRD RESPONSE AND DISEASE KINETICS: RESULTS FROM THE TRIANGLE TRIAL
137 | IBRUTINIB ADDED TO MCL TREATMENT HAS STRONG IMPACT ON MRD RESPONSE AND DISEASE KINETICS: RESULTS FROM THE TRIANGLE TRIAL Open
View article: 267 | EVALUATION OF ESTABLISHED PROGNOSTIC MARKERS IN YOUNGER MANTLE CELL LYMPHOMA PATIENTS UNDER IBRUTINIB CONTAINING REGIMENS—AN ANALYSIS EMBEDDED IN THE MULTIPLY PROJECT
267 | EVALUATION OF ESTABLISHED PROGNOSTIC MARKERS IN YOUNGER MANTLE CELL LYMPHOMA PATIENTS UNDER IBRUTINIB CONTAINING REGIMENS—AN ANALYSIS EMBEDDED IN THE MULTIPLY PROJECT Open
View article: Common origin and somatic mutation patterns of composite lymphomas and leukemias
Common origin and somatic mutation patterns of composite lymphomas and leukemias Open
When two lymphomas occur concurrently or sequentially in a patient, it is a major question whether they derive from the same lymphocyte or hematopoietic precursor cell or developed independently. We studied four composite classic Hodgkin l…
View article: TCRanalyzer: A user-friendly tool for comprehensive analysis of T-cell diversity, dynamics and potential antigen targets
TCRanalyzer: A user-friendly tool for comprehensive analysis of T-cell diversity, dynamics and potential antigen targets Open
T cells are critical for immune responses, recognizing antigens via their unique T-cell receptors (TCRs). Analyzing the diverse TCR repertoires, especially the hypervariable CDR3 region, is essential for understanding immune function in he…
View article: Refining histopathological growth pattern-based risk group discrimination in nodular lymphocyte-predominant Hodgkin lymphoma: an analysis from the German Hodgkin Study Group
Refining histopathological growth pattern-based risk group discrimination in nodular lymphocyte-predominant Hodgkin lymphoma: an analysis from the German Hodgkin Study Group Open
Histopathological growth patterns (GP) in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) have previously been divided into GP AB (typical) vs CDEF (variant). However, it is unclear whether this division is optimal. We thus investi…
View article: Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study
Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study Open
View article: Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma Open
The success of targeted therapies for hematological malignancies has heralded their potential as both salvage treatment and early treatment lines, reducing the need for high-dose, intensive, and often toxic chemotherapeutic regimens. For y…
View article: Subtyping Burkitt Lymphoma by <scp>DNA</scp> Methylation
Subtyping Burkitt Lymphoma by <span>DNA</span> Methylation Open
Burkitt lymphoma (BL) is an aggressive germinal center B‐cell‐derived malignancy. Historically, sporadic, endemic, and immunodeficiency‐associated variants were distinguished, which differ in the frequency of Epstein–Barr virus (EBV) posit…
View article: Correction: Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials
Correction: Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials Open
View article: Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials
Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials Open
View article: Mutation profiling in differential diagnosis between TdT-positive high grade/large B-cell lymphoma and B-lymphoblastic leukaemia/lymphoma
Mutation profiling in differential diagnosis between TdT-positive high grade/large B-cell lymphoma and B-lymphoblastic leukaemia/lymphoma Open
TdT is occasionally expressed in large B-cell lymphoma (LBCL), and this causes difficulty in differential diagnosis from B-lymphoblastic leukaemia/lymphomas (B-ALL/LBL). We reviewed 31 cases of TdT-positive LBCL and B-ALL/LBL, and their fi…
View article: Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules
Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules Open
View article: Age‐ and gender‐specific molecular characteristics of diffuse large B‐cell lymphoma: Results from clinical trials of the DSHNHL/GLA
Age‐ and gender‐specific molecular characteristics of diffuse large B‐cell lymphoma: Results from clinical trials of the DSHNHL/GLA Open
Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma. Despite a high cure rate, too many patients show refractory (ref) or relapsed (rel) disease. This study examines the frequency of recurring gene mutations and t…
View article: Integrating genetic subtypes with PET scan monitoring to predict outcome in diffuse large B-cell lymphoma
Integrating genetic subtypes with PET scan monitoring to predict outcome in diffuse large B-cell lymphoma Open
View article: <scp>MicroRNA</scp> Expression in High‐Grade B‐Cell Lymphoma With 11q Aberration
<span>MicroRNA</span> Expression in High‐Grade B‐Cell Lymphoma With 11q Aberration Open
Mature aggressive B‐cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large B‐cell lymphoma (DLBCL), show variations in microRNA (miRNA) expression. The entity of High‐grade B‐cell lymphoma with 11q aberration (HGBCL‐11q) shares se…
View article: T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma
T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma Open
View article: Abstracts from the 57th European Society of Human Genetics (ESHG) Conference: Hybrid Posters
Abstracts from the 57th European Society of Human Genetics (ESHG) Conference: Hybrid Posters Open
View article: Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas Open
View article: Case report: Tenosynovial giant cell tumor
Case report: Tenosynovial giant cell tumor Open
Tenosynovial giant cell tumor (TGCT) is a rare type of tumor that originates from the synovium of joints and tendon sheaths. It is characterized by recurring genetic abnormalities, often involving the CSF1 gene. Common symptoms include pai…
View article: Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials
Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials Open
View article: T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma
T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma Open
The Tumor Microenvironment (TME) in classical Hodgkin lymphoma (HL) contains abundant immune cells and only few neoplastic Hodgkin and Reed-Sternberg cells (HRSC). We analyzed the T-cell receptor (TCR) repertoire to detect T-cell expansion…
View article: A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors
A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors Open
Genetic TNFAIP3 (A20) inactivation is a classical somatic lymphoma lesion and the genomic trait in haploinsufficiency of A20 (HA20). In a cohort of 34 patients with HA20, we show that heterozygous TNFAIP3 loss skews immune repertoires towa…