Daniel A. Low
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View article: Modern Approaches for Thoracic Image Registration and Respiratory Motion Management in Oncology
Modern Approaches for Thoracic Image Registration and Respiratory Motion Management in Oncology Open
This review serves as a key reference for researchers, physicists, and clinicians on recent developments, software tools, evaluation metrics, and strategies for thoracic image registration and respiratory motion management in oncology.
View article: A Retrospective Analysis of the First Clinical 5DCT Workflow
A Retrospective Analysis of the First Clinical 5DCT Workflow Open
Background/Objectives: 5DCT was first proposed in 2005 as a motion-compensated CT simulation approach for radiotherapy treatment planning to avoid sorting artifacts that arise in 4DCT when patients breathe irregularly. Since March 2019, 5D…
View article: Introducing a novel sub‐millimeter lung CT image registration error quantitation tool
Introducing a novel sub‐millimeter lung CT image registration error quantitation tool Open
Background Lung computed tomography (CT) scan image registration is being used for lung function analysis such as ventilation. Given the high sensitivity of functional analyses to image registration errors, an image registration error scor…
View article: A Comparative Study of Structured and Cut-Cell Grids Applied to an Oil-Injected Screw Compressor
A Comparative Study of Structured and Cut-Cell Grids Applied to an Oil-Injected Screw Compressor Open
Discretized Partial Differential Equations (PDEs) for numerical modeling of fluid mechanics systems require the use of various iterative linear solvers. In this study, two different CFD solvers, Ansys CFX and Converge, were employed to dev…
View article: A generalized software framework for consolidation of radiotherapy planning and delivery data from diverse data sources
A generalized software framework for consolidation of radiotherapy planning and delivery data from diverse data sources Open
Aggregating large-scale radiotherapy planning and delivery data is crucial for advancing radiation oncology research and improving clinical practice, yet challenges persist due to the diversity of treatment planning systems (TPS), record a…
View article: Magnetic Resonance Imaging Versus Computed Tomography Guidance for Stereotactic Body Radiotherapy in Prostate Cancer: 2-year Outcomes from the MIRAGE Randomized Clinical Trial
Magnetic Resonance Imaging Versus Computed Tomography Guidance for Stereotactic Body Radiotherapy in Prostate Cancer: 2-year Outcomes from the MIRAGE Randomized Clinical Trial Open
It has been shown that magnetic resonance imaging (MRI) guidance versus computed tomography (CT) guidance for aggressive margin-reduction (AMR) for stereotactic body radiotherapy (SBRT) in prostate cancer reduces acute toxicity, but the lo…
View article: Symmetry, separation, and stability: Physical properties for effective dosimetric space with a stabilized hyaluronic acid spacer
Symmetry, separation, and stability: Physical properties for effective dosimetric space with a stabilized hyaluronic acid spacer Open
Background The proximity of the rectum to the prostate in radiation therapy (RT) for prostate cancer presents a significant dosimetric challenge, leading to high rectal doses and resulting in detrimental side effects. Perirectal tissue spa…
View article: Long-Term Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Noninferiority Study Comparing Two Fractionation Schedules in Patients With Low-Risk Prostate Cancer
Long-Term Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Noninferiority Study Comparing Two Fractionation Schedules in Patients With Low-Risk Prostate Cancer Open
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …
View article: Results of an Artificial Intelligence-Based Image Review System to Detect Patient Misalignment Errors in a Multi-institutional Database of Cone Beam Computed Tomography-Guided Radiation Therapy
Results of an Artificial Intelligence-Based Image Review System to Detect Patient Misalignment Errors in a Multi-institutional Database of Cone Beam Computed Tomography-Guided Radiation Therapy Open
Our results validated the clinical utility of the EDA for bulk image reviews and highlighted the reliability and safety of IGRT, with an absolute gross patient misalignment error rate of 0.04% ± 0.02% per delivered fraction.
View article: Automated detection of vertebral body misalignments in orthogonal kV and MV guided radiotherapy: application to a comprehensive retrospective dataset
Automated detection of vertebral body misalignments in orthogonal kV and MV guided radiotherapy: application to a comprehensive retrospective dataset Open
Objective . In image-guided radiotherapy (IGRT), off-by-one vertebral body misalignments are rare but potentially catastrophic. In this study, a novel detection method for such misalignments in IGRT was investigated using densely-connected…
View article: Accelerated Hypofractionated Chemoradiation Followed by Stereotactic Ablative Radiotherapy Boost for Locally Advanced, Unresectable Non–Small Cell Lung Cancer
Accelerated Hypofractionated Chemoradiation Followed by Stereotactic Ablative Radiotherapy Boost for Locally Advanced, Unresectable Non–Small Cell Lung Cancer Open
Importance Intrathoracic progression remains the predominant pattern of failure in patients treated with concurrent chemoradiation followed by a consolidation immune checkpoint inhibitor for locally advanced, unresectable non–small cell lu…
View article: Evaluating the Quality-of-Life Effect of Apical Spacing with Hyaluronic Acid Prior to Hypofractionated Prostate Radiation Therapy: A Secondary Analysis
Evaluating the Quality-of-Life Effect of Apical Spacing with Hyaluronic Acid Prior to Hypofractionated Prostate Radiation Therapy: A Secondary Analysis Open
Greater apical spacing was associated with improved rectal dosimetry and smaller decline in bowel QOL at 3-months. Further prospective data are needed to fully understand the ramifications of increased apical spacing.
View article: An analysis of the regional heterogeneity in tissue elasticity in lung cancer patients with COPD
An analysis of the regional heterogeneity in tissue elasticity in lung cancer patients with COPD Open
Purpose Recent advancements in obtaining image-based biomarkers from CT images have enabled lung function characterization, which could aid in lung interventional planning. However, the regional heterogeneity in these biomarkers has not be…
View article: Predicting Overall Survival for Patients with Malignant Mesothelioma Following Radiotherapy via Interpretable Machine Learning
Predicting Overall Survival for Patients with Malignant Mesothelioma Following Radiotherapy via Interpretable Machine Learning Open
Purpose/Objectives: Malignant pleural mesothelioma (MPM) is a rare but aggressive cancer arising from the cells of the thoracic pleura with a poor prognosis. We aimed to develop a model, via interpretable machine learning (ML) methods, pre…
View article: Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy
Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy Open
Importance Hypofractionated radiation therapy (RT) for prostate cancer has been associated with greater acute grade 2 gastrointestinal (GI) toxic effects compared with conventionally fractionated RT. Objective To evaluate whether a hyaluro…
View article: Magnetic Resonance Imaging–Guided vs Computed Tomography–Guided Stereotactic Body Radiotherapy for Prostate Cancer
Magnetic Resonance Imaging–Guided vs Computed Tomography–Guided Stereotactic Body Radiotherapy for Prostate Cancer Open
Importance Magnetic resonance imaging (MRI) guidance offers multiple theoretical advantages in the context of stereotactic body radiotherapy (SBRT) for prostate cancer. However, to our knowledge, these advantages have yet to be demonstrate…
View article: 13 How to diagnose, treat and eliminate racial and ethnic disparities in our healthcare systems
13 How to diagnose, treat and eliminate racial and ethnic disparities in our healthcare systems Open
Background Racial and ethnic disparities exist. We can stratify processes of care and outcomes by race & ethnicity and language to identify disparities. Objectives Identify and eliminate disparities in patients having tonsillectomy surgery…
View article: Urethral Interfractional Geometric and Dosimetric Variations of Prostate Cancer Patients: A Study Using an Onboard MRI
Urethral Interfractional Geometric and Dosimetric Variations of Prostate Cancer Patients: A Study Using an Onboard MRI Open
Purpose For a cohort of prostate cancer patients treated on an MR-guided radiotherapy (MRgRT) system, we retrospectively analyzed urethral interfractional geometric and dosimetric variations based on onboard MRIs acquired at different time…
View article: Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians
Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians Open
Radiation therapy (RT) continues to play an important role in the treatment of cancer. Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the ART approach, computed tomography or magnetic resonance (MR) imag…