W. Nicholas Haining
YOU?
Author Swipe
View article: 256 Preclinical development of AB-3028, a logic-gated engineered CAR T cell product intended for the treatment of metastatic castration-resistant prostate cancer (mCRPC)
256 Preclinical development of AB-3028, a logic-gated engineered CAR T cell product intended for the treatment of metastatic castration-resistant prostate cancer (mCRPC) Open
View article: 245 Synthetic pathway activators (SPA) enhance CAR-T activity against solid tumors by reducing T cell exhaustion and increasing functional persistence in preclinical studies
245 Synthetic pathway activators (SPA) enhance CAR-T activity against solid tumors by reducing T cell exhaustion and increasing functional persistence in preclinical studies Open
View article: 303 AB-3028: Dual-targeting sequential AND logic gated CAR T cell for potential mCRPC therapeutic
303 AB-3028: Dual-targeting sequential AND logic gated CAR T cell for potential mCRPC therapeutic Open
View article: 258 Programmable circuit T cells encoding multiplexed shRNAs and logic-gates for mCRPC
258 Programmable circuit T cells encoding multiplexed shRNAs and logic-gates for mCRPC Open
View article: 1125 gx1: virtual target identification for overcoming T cell exhaustion
1125 gx1: virtual target identification for overcoming T cell exhaustion Open
View article: Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control Open
PD-1 is a key negative regulator of CD8+ T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1 blockade can improve viral and tumor control, physiological PD-1 expression preven…
View article: 334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens
334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens Open
View article: 282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial <i>in vitro</i> CRISPR screening followed by <i>in vivo</i> validation
282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial <i>in vitro</i> CRISPR screening followed by <i>in vivo</i> validation Open
View article: Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine Open
A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a clinical trial of the radiation-attenuated whole-sporozoite PfSPZ vaccine in Afric…
View article: X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system Open
View article: Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation Open
Figure S1. Characterization of cells and CDK4/6 inhibitors; Figure S2. CDK6 phosphorylates serine residues of the regulatory domain of NFAT4 (NFATc3); Figure S3. Analysis of lung tumor immune infiltrates after CDK4/6 inhibition from KrasG1…
View article: Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation Open
Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance the efficacy of existing immunotherapies, we screened for small molecules capable of incre…
View article: Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation Open
Figure S1. Characterization of cells and CDK4/6 inhibitors; Figure S2. CDK6 phosphorylates serine residues of the regulatory domain of NFAT4 (NFATc3); Figure S3. Analysis of lung tumor immune infiltrates after CDK4/6 inhibition from KrasG1…
View article: Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation Open
Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can induce durable tumor regressions in some patients. To enhance the efficacy of existing immunotherapies, we screened for small molecules capable of incre…
View article: Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans Open
Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
View article: Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans Open
Purpose: CpG oligodeoxynucleotides (CpG-ODN) are being investigated as cancer vaccine adjuvants because they mature plasmacytoid dendritic cells (PDC) into potent antigen-presenting cells. CpG-ODN also induce PDC to secrete chemokin…
View article: Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans Open
Purpose: CpG oligodeoxynucleotides (CpG-ODN) are being investigated as cancer vaccine adjuvants because they mature plasmacytoid dendritic cells (PDC) into potent antigen-presenting cells. CpG-ODN also induce PDC to secrete chemokin…
View article: Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans Open
Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
View article: Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
The identification of new tumor-associated antigens (TAA) is critical for the development of effective immunotherapeutic strategies, particularly in diseases like B-cell acute lymphoblastic leukemia (B-ALL), where few target epitopes are k…
View article: Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
Supplementary Tables 1-3 from Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
View article: Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
The identification of new tumor-associated antigens (TAA) is critical for the development of effective immunotherapeutic strategies, particularly in diseases like B-cell acute lymphoblastic leukemia (B-ALL), where few target epitopes are k…
View article: Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
Supplementary Tables 1-3 from Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
View article: Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion Open
View article: 332 CRISPR/Cas9-based integration of a large and modular cassette into a safe harbor site to improve CAR T cell therapy efficacy and safety
332 CRISPR/Cas9-based integration of a large and modular cassette into a safe harbor site to improve CAR T cell therapy efficacy and safety Open
Background Chimeric antigen receptor (CAR) T cell therapy has emerged as an important new tool in the treatment of cancers. However, the complexity of the enhancements used is limited by the amount of genetic information that can be integr…
View article: When Cancer Cells Become the Enablers of an Antitumor Immune Response
When Cancer Cells Become the Enablers of an Antitumor Immune Response Open
Summary: Tumor-specific cytotoxic T cells unleashed by the blockade of immune checkpoints have to overcome a hostile tumor microenvironment (TME). They start from very small numbers of T cells with tumor antigen specificity and, despite ex…
View article: PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment Open
Background Oncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood. Methods We use an in vivo expression scree…
View article: Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine
Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine Open
Baseline innate immune signatures can influence protective immunity following vaccination. Here, we used systems transcriptional analysis to assess the molecular mechanisms underlying differential immunogenicity and protective efficacy res…
View article: Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans Open
View article: Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory Open
View article: Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy
Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy Open
T cell dysfunction occurs early following HIV infection, impacting the emergence of non-AIDS morbidities and limiting curative efforts. ART initiated during primary HIV infection (PHI) can reverse this dysfunction, but the extent of recove…