W. Paul Segars
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View article: Large Intestine 3D Shape Refinement Using Conditional Latent Point Diffusion Models
Large Intestine 3D Shape Refinement Using Conditional Latent Point Diffusion Models Open
View article: Development of a deep learning based approach for multi-material decomposition in spectral CT: a proof of principle in silico study
Development of a deep learning based approach for multi-material decomposition in spectral CT: a proof of principle in silico study Open
Conventional approaches to material decomposition in spectral CT face challenges related to precise algorithm calibration across imaged conditions and low signal quality caused by variable object size and reduced dose. In this proof-of-pri…
View article: S-values for bone marrow dosimetry in preclinical radiopharmaceutical studies with rodents
S-values for bone marrow dosimetry in preclinical radiopharmaceutical studies with rodents Open
Background Development of novel radiopharmaceuticals involves dosimetry calculations to validate safety and aid with selection of those that should be translated into the clinical environment. Dosimetry is critical for limiting radiation d…
View article: Library of realistic 4D digital beating heart models based on patient CT data
Library of realistic 4D digital beating heart models based on patient CT data Open
Background The prevalence of cardiovascular disease (CVD) has risen alongside new medical imaging technologies designed for its diagnosis and treatment. Computational phantoms play a crucial role in imaging research, supporting application…
View article: Transforming body composition of computational phantoms based on form‐finding dynamics
Transforming body composition of computational phantoms based on form‐finding dynamics Open
Background There is a lack of representation available for computational phantoms with variable muscle and fat composition representing the overall population. Changes in body composition are known to significantly affect image quality of …
View article: Volumetric soft tissue perfusion assessment on a region basis from x‐ray angiography images: Motion compensation
Volumetric soft tissue perfusion assessment on a region basis from x‐ray angiography images: Motion compensation Open
Background Assessing the soft tissue perfusion quantitatively in interventional suites before, during, and after interventional procedures is desired. The method, if possible, has to assess the perfusion volumetrically and quantitatively, …
View article: Virtual Lung Screening Trial (VLST): An <i>In Silico</i> Study Inspired by the National Lung Screening Trial for Lung Cancer Detection.
Virtual Lung Screening Trial (VLST): An <i>In Silico</i> Study Inspired by the National Lung Screening Trial for Lung Cancer Detection. Open
Clinical imaging trials play a crucial role in advancing medical innovation but are often costly, inefficient, and ethically constrained. Virtual Imaging Trials (VITs) present a solution by simulating clinical trial components in a control…
View article: Virtual imaging trials in medicine: A brief takeaway of the lessons from the first international summit
Virtual imaging trials in medicine: A brief takeaway of the lessons from the first international summit Open
Background The rapid advancement of medical technologies presents significant challenges for researchers and practitioners. While traditional clinical trials remain the gold standard, they are often limited by high costs, lengthy durations…
View article: Simulating cardiac fluid dynamics in the human heart.
Simulating cardiac fluid dynamics in the human heart. Open
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin valve leaflets. There has been longstanding scientific, engineering, and medica…
View article: Simulating cardiac fluid dynamics in the human heart
Simulating cardiac fluid dynamics in the human heart Open
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin valve leaflets. There has been longstanding scientific, engineering, and medica…
View article: Estimation of threshold thickness of residual normal tissue in lung dysfunction detectable by dynamic chest radiography: A virtual imaging trial
Estimation of threshold thickness of residual normal tissue in lung dysfunction detectable by dynamic chest radiography: A virtual imaging trial Open
Background Dynamic chest radiography (DCR) is a recently developed functional x‐ray imaging technique that detects pulmonary ventilation impairment as a decrease in changes in lung density during respiration. However, the diagnostic perfor…
View article: CardSegNet: An adaptive hybrid CNN-vision transformer model for heart region segmentation in cardiac MRI
CardSegNet: An adaptive hybrid CNN-vision transformer model for heart region segmentation in cardiac MRI Open
View article: Quantitative accuracy of lung function measurement using parametric response mapping: a virtual imaging study
Quantitative accuracy of lung function measurement using parametric response mapping: a virtual imaging study Open
Parametric response mapping (PRM) is a voxel-based quantitative CT imaging biomarker that measures the severity of chronic obstructive pulmonary disease (COPD) by analyzing both inspiratory and expiratory CT scans. Although PRM-derived mea…
View article: Development of physiologically‐informed computational coronary artery plaques for use in virtual imaging trials
Development of physiologically‐informed computational coronary artery plaques for use in virtual imaging trials Open
Background As a leading cause of death, worldwide, cardiovascular disease is of great clinical importance. Among cardiovascular diseases, coronary artery disease (CAD) is a key contributor, and it is the attributed cause of death for 10% o…
View article: Coronary stenosis quantification in cardiac computed tomography angiography: multi-factorial optimization of image quality and radiation dose
Coronary stenosis quantification in cardiac computed tomography angiography: multi-factorial optimization of image quality and radiation dose Open
The protocol optimization framework provides means to assess and optimize CTA in terms of either image quality or radiation dose objectives with its results predicting prior clinical trial findings.
View article: Surface-based anthropomorphic bone structures for use in high-resolution simulated medical imaging
Surface-based anthropomorphic bone structures for use in high-resolution simulated medical imaging Open
Objective. Virtual imaging trials enable efficient assessment and optimization of medical image devices and techniques via simulation rather than physical studies. These studies require realistic, detailed ground-truth models or phantoms o…
View article: The Utility of the Virtual Imaging Trials Methodology for Objective Characterization of AI Systems and Training Data
The Utility of the Virtual Imaging Trials Methodology for Objective Characterization of AI Systems and Training Data Open
Purpose: The credibility of Artificial Intelligence (AI) models for medical imaging continues to be a challenge, affected by the diversity of models, the data used to train the models, and applicability of their combination to produce repr…
View article: Simulating Cardiac Fluid Dynamics in the Human Heart
Simulating Cardiac Fluid Dynamics in the Human Heart Open
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering, …
View article: Modeling the effect of patient size on cerebral perfusion during veno-arterial extracorporeal membrane oxygenation
Modeling the effect of patient size on cerebral perfusion during veno-arterial extracorporeal membrane oxygenation Open
Introduction A well-known complication of veno-arterial extracorporeal membrane oxygenation (VA ECMO) is differential hypoxia, in which poorly-oxygenated blood ejected from the left ventricle mixes with and displaces well-oxygenated blood …
View article: A systematic assessment of photon-counting CT for bone mineral density and microarchitecture quantifications
A systematic assessment of photon-counting CT for bone mineral density and microarchitecture quantifications Open
Photon-counting CT (PCCT) is an emerging imaging technology with potential improvements in quantification and rendition of micro-structures due to its smaller detector sizes. The aim of this study was to assess the performance of a new PCC…
View article: Development and application of a virtual imaging trial framework for airway quantifications via CT
Development and application of a virtual imaging trial framework for airway quantifications via CT Open
Chronic obstructive pulmonary disease (COPD) is one of the top three causes of death worldwide, characterized by emphysema and bronchitis. Airway measurements reflect the severity of bronchitis and other airway-related diseases. Air…
View article: Phase-contrast virtual chest radiography
Phase-contrast virtual chest radiography Open
Respiratory X-ray imaging enhanced by phase contrast has shown improved airway visualization in animal models. Limitations in current X-ray technology have nevertheless hindered clinical translation, leaving the potential clinical impact a…
View article: Emphysema Quantifications With CT Scan
Emphysema Quantifications With CT Scan Open
View article: TransMorph: Transformer for unsupervised medical image registration
TransMorph: Transformer for unsupervised medical image registration Open
View article: XCIST—an open access x-ray/CT simulation toolkit
XCIST—an open access x-ray/CT simulation toolkit Open
Objective . X-ray-based imaging modalities including mammography and computed tomography (CT) are widely used in cancer screening, diagnosis, staging, treatment planning, and therapy response monitoring. Over the past few decades, improvem…
View article: Development of scalable lymphatic system in the 4D XCAT phantom: Application to quantitative evaluation of lymphoma PET segmentations
Development of scalable lymphatic system in the 4D XCAT phantom: Application to quantitative evaluation of lymphoma PET segmentations Open
Background Digital anthropomorphic phantoms, such as the 4D extended cardiac‐torso (XCAT) phantom, are actively used to develop, optimize, and evaluate a variety of imaging applications, allowing for realistic patient modeling and knowledg…
View article: Supporting data: phase-contrast virtual chest radiography
Supporting data: phase-contrast virtual chest radiography Open
This dataset contains supporting data for the publication below (currently under review): If you use this dataset, please cite: Ilian Häggmark, Kian Shaker, Sven Nyrén, Bariq Al-Amiry, Ehsan Abadi, William Segars, Ehsan Sa…
View article: Supporting data: phase-contrast virtual chest radiography
Supporting data: phase-contrast virtual chest radiography Open
This dataset contains supporting data for the publication below: Ilian Häggmark, Kian Shaker, Sven Nyrén, Bariq Al-Amiry, Ehsan Abadi, William P. Segars, Ehsan Samei, and Hans M. Hertz, "Phase-contrast virtual chest radiography", …
View article: Supporting data: phase-contrast virtual chest radiography
Supporting data: phase-contrast virtual chest radiography Open
This dataset contains supporting data for the publication below: Ilian Häggmark, Kian Shaker, Sven Nyrén, Bariq Al-Amiry, Ehsan Abadi, William P. Segars, Ehsan Samei, and Hans M. Hertz, "Phase-contrast virtual chest radiography", …
View article: Model‐based pulse pileup and charge sharing compensation for photon counting detectors: A simulation study
Model‐based pulse pileup and charge sharing compensation for photon counting detectors: A simulation study Open
Purpose We aim at developing a model‐based algorithm that compensates for the effect of both pulse pileup (PP) and charge sharing (CS) and evaluates the performance using computer simulations. Methods The proposed PCP algorithm for PP and …