W. Robert McMaster
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View article: Identifying early intervention opportunities for illicit stimulant use: A cross-sectional study of factors associated with illicit stimulant use among young people accessing integrated youth services in British Columbia, Canada
Identifying early intervention opportunities for illicit stimulant use: A cross-sectional study of factors associated with illicit stimulant use among young people accessing integrated youth services in British Columbia, Canada Open
These risk/protective factors support identification of young people who may benefit from further screening, assessment, and treatment for illicit stimulant use. This study also underscores the need to expand early intervention and harm re…
View article: High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation Open
View article: Population Frequencies Determined by Next-generation Sequencing Provide Strategies for Prospective HLA Epitope Matching for Transplantation
Population Frequencies Determined by Next-generation Sequencing Provide Strategies for Prospective HLA Epitope Matching for Transplantation Open
Compatibility for human leukocyte antigen (HLA) genes between transplant donors and recipients improves graft survival but prospective matching is rarely performed due to the vast heterogeneity of this gene complex. To reduce complexity, w…
View article: Analytical Validation of HEARTBiT: A Blood-Based Multiplex Gene Expression Profiling Assay for Exclusionary Diagnosis of Acute Cellular Rejection in Heart Transplant Patients
Analytical Validation of HEARTBiT: A Blood-Based Multiplex Gene Expression Profiling Assay for Exclusionary Diagnosis of Acute Cellular Rejection in Heart Transplant Patients Open
Background HEARTBiT is a whole blood-based gene profiling assay using the nucleic acid counting NanoString technology for the exclusionary diagnosis of acute cellular rejection in heart transplant patients. The HEARTBiT score measures the …
View article: PGCA: An algorithm to link protein groups created from MS/MS data
PGCA: An algorithm to link protein groups created from MS/MS data Open
The quantitation of proteins using shotgun proteomics has gained popularity in the last decades, simplifying sample handling procedures, removing extensive protein separation steps and achieving a relatively high throughput readout. The pr…
View article: Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression
Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression Open
Cysteine peptidases play a central role in the biology of Leishmania. In this work, we sought to further elucidate the mechanism(s) by which the cysteine peptidase CPB contributes to L. mexicana virulence and whether CPB participates in th…
View article: Cost-Effectiveness of a Blood-Based Biomarker Compared to Endomyocardial Biopsy for the Diagnosis of Acute Allograft Rejection
Cost-Effectiveness of a Blood-Based Biomarker Compared to Endomyocardial Biopsy for the Diagnosis of Acute Allograft Rejection Open
View article: Biomarkers Monitoring for Absence of Acute Allograft Rejection
Biomarkers Monitoring for Absence of Acute Allograft Rejection Open
View article: Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity
Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity Open
Leishmania parasites are a major public health problem worldwide. Effective treatment of leishmaniasis is hampered by the high incidence of adverse effects to traditional drug therapy and the emergence of resistance to current therapeutics…
View article: Impact of Leishmania Infection on Host Macrophage Nuclear Physiology and Nucleopore Complex Integrity
Impact of Leishmania Infection on Host Macrophage Nuclear Physiology and Nucleopore Complex Integrity Open
The protease GP63 is an important virulence factor of Leishmania parasites. We previously showed that GP63 reaches the perinuclear area of host macrophages and that it directly modifies nuclear translocation of the transcription factors NF…