Scott W. Hiebert
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View article: eNRSA: a faster and more powerful approach for nascent transcriptome analysis
eNRSA: a faster and more powerful approach for nascent transcriptome analysis Open
Nascent RNA sequencing tracks primary transcriptional events, making it crucial for studying the immediate regulatory changes of genes and enhancers in response to both endogenous and exogenous stimuli. NRSA is a widely used tool for analy…
View article: Expression-Driven Genetic Dependency Reveals Targets for Precision Medicine
Expression-Driven Genetic Dependency Reveals Targets for Precision Medicine Open
Cancer cells are heterogeneous, each harboring distinct molecular aberrations and are dependent on different genes for their survival and proliferation. While successful targeted therapies have been developed based on driver DNA mutations,…
View article: MTGR1 is required to maintain small intestinal stem cell populations
MTGR1 is required to maintain small intestinal stem cell populations Open
Undifferentiated intestinal stem cells (ISCs) are crucial for maintaining homeostasis and resolving injury. Lgr5 + cells in the crypt base constantly divide, pushing daughter cells upward along the crypt axis where they differentiate into …
View article: Mutant FOXO1 controls an oncogenic network via enhancer accessibility
Mutant FOXO1 controls an oncogenic network via enhancer accessibility Open
Transcriptional dysregulation is a hallmark of diffuse large B cell lymphoma (DLBCL), as transcriptional regulators are frequently mutated. However, our mechanistic understanding of how normal transcriptional programs are co-opted in DLBCL…
View article: Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci
Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci Open
Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tightening, and therefore, HDACs are…
View article: Jedi‐1/MEGF12‐mediated phagocytosis controls the pro‐neurogenic properties of microglia in the ventricular‐subventricular zone
Jedi‐1/MEGF12‐mediated phagocytosis controls the pro‐neurogenic properties of microglia in the ventricular‐subventricular zone Open
Background The act of engulfing cellular debris profoundly shapes phagocyte phenotypes and, thus, determines tissue‐specific phagocyte function. A population of microglia with unique characteristics resides in the ventricular‐subventricula…
View article: MTGR1 is required to maintain small intestinal stem cell populations
MTGR1 is required to maintain small intestinal stem cell populations Open
Undifferentiated intestinal stem cells (ISCs), particularly those marked by Lgr5, are crucial for maintaining homeostasis and resolving injury. Lgr5+ cells in the crypt base constantly divide, pushing daughter cells upward along the crypt …
View article: Chemical-genetics refines transcription factor regulatory circuits
Chemical-genetics refines transcription factor regulatory circuits Open
View article: Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3–FOXO1 in rhabdomyosarcoma
Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3–FOXO1 in rhabdomyosarcoma Open
Recurrent chromosomal rearrangements found in rhabdomyosarcoma (RMS) produce the PAX3–FOXO1 fusion protein, which is an oncogenic driver and a dependency in this disease. One important function of PAX3–FOXO1 is to arrest myogenic different…
View article: A dual indexed approach to small RNA sequencing library preparation for PRO-seq
A dual indexed approach to small RNA sequencing library preparation for PRO-seq Open
Advances in next generation sequencing (NGS) technologies have vastly increased the number of samples that can be sequenced together and reduced the cost per sample. To fully utilize the increased capacity of standard sequencers, samples m…
View article: Supplementary Table S1 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S1 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
All pathways used in pathway enrichment analysis.
View article: Supplementary Table S5 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S5 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
A list of CREBBP mutations in cohort 3.
View article: Supplementary Table S4 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S4 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
A list of CREBBP mutations in cohorts 1 and 2.
View article: Supplementary Table S6 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S6 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
A list of primer sequences used in Figure 5.
View article: Supplementary Table S3 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S3 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
Patient info for cohorts 1 and 2.
View article: Supplementary Table S5 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S5 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
A list of CREBBP mutations in cohort 3.
View article: Supplementary Table S1 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S1 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
All pathways used in pathway enrichment analysis.
View article: Supplementary Table S6 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S6 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
A list of primer sequences used in Figure 5.
View article: Supplementary Figures S1 - S14 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Figures S1 - S14 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
Supplementary Figure S1. Crebbp deficiency results in accelerated germinal center derived B-cell lymphoma development in mice. Supplementary Figure S2. Ep300 deficiency results in accelerated germinal center derived B-cell lymphoma develop…
View article: Supplementary Table S2 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S2 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
All the enriched pathways in various analyses.
View article: Data from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Data from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)–derived lymphomas in mice. In both human and murine lymphomas, CREBBP loss-of-fun…
View article: Supplementary Table S3 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S3 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
Patient info for cohorts 1 and 2.
View article: Supplementary Table S2 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S2 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
All the enriched pathways in various analyses.
View article: Supplementary Figures S1 - S14 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Figures S1 - S14 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
Supplementary Figure S1. Crebbp deficiency results in accelerated germinal center derived B-cell lymphoma development in mice. Supplementary Figure S2. Ep300 deficiency results in accelerated germinal center derived B-cell lymphoma develop…
View article: Supplementary Table S4 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Supplementary Table S4 from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
A list of CREBBP mutations in cohorts 1 and 2.
View article: Data from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
Data from <i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas Open
Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates the development of germinal center (GC)–derived lymphomas in mice. In both human and murine lymphomas, CREBBP loss-of-fun…
View article: Data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia
Data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia Open
Purpose:The BCL2 inhibitor, venetoclax, has transformed clinical care in acute myeloid leukemia (AML). However, subsets of patients do not respond or eventually acquire resistance. Venetoclax-based regimens can lead to considerable marrow …
View article: Supplemental data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia
Supplemental data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia Open
Supplemental data
View article: Data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia
Data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia Open
Purpose:The BCL2 inhibitor, venetoclax, has transformed clinical care in acute myeloid leukemia (AML). However, subsets of patients do not respond or eventually acquire resistance. Venetoclax-based regimens can lead to considerable marrow …
View article: Supplemental data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia
Supplemental data from BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia Open
Supplemental data