Wiktor Szymański
YOU?
Author Swipe
View article: Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Highlight selection of radiochemistry and radiopharmacy developments by editorial board Open
View article: Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation.
Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation. Open
Light is often the stimulus of choice for dynamically changing function in materials, from controlling phase transitions and dynamic chemistry to in-situ polymerizations, crosslinking, and 3D printing. The high temporal and spatial control…
View article: Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation.
Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with in-situ irradiation. Open
Light is often the stimulus of choice for dynamically changing function in materials, from controlling phase transitions and dynamic chemistry to in-situ polymerizations, crosslinking, and 3D printing. The high temporal and spatial control…
View article: Green-Light-Activatable Penicillin for Light-Dependent Spatial Control of Bacterial Growth, Biofilm Formation, and <i>In Vivo</i> Infection Treatment
Green-Light-Activatable Penicillin for Light-Dependent Spatial Control of Bacterial Growth, Biofilm Formation, and <i>In Vivo</i> Infection Treatment Open
Our ability to prevent, treat, and cure bacterial infections is nowadays seriously threatened by the rise of (multidrug) antimicrobial resistance (AMR), and novel molecular approaches in the antibacterial arsenal are urgently needed. To fi…
View article: Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement
Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement Open
Purpose Bacterial infections associated with musculoskeletal injuries are challenging to detect and distinguish from sterile inflammation. Here we present the combined first-time application of a bacteria-targeted positron emission tomogra…
View article: Manipulation of Chemistry and Biology with Visible Light Using Tetra‐<i>ortho</i>‐Substituted Azobenzenes and Azonium Ions
Manipulation of Chemistry and Biology with Visible Light Using Tetra‐<i>ortho</i>‐Substituted Azobenzenes and Azonium Ions Open
Molecular photoswitches are used for precise and reversible control over the properties and function of chemical, biological and material systems, offering exceptional spatiotemporal control. Their current development focuses on enabling o…
View article: Manipulation of Chemistry and Biology with Visible Light Using Tetra‐<i>ortho</i>‐Substituted Azobenzenes and Azonium Ions
Manipulation of Chemistry and Biology with Visible Light Using Tetra‐<i>ortho</i>‐Substituted Azobenzenes and Azonium Ions Open
Molecular photoswitches are used for precise and reversible control over the properties and function of chemical, biological and material systems, offering exceptional spatiotemporal control. Their current development focuses on enabling o…
View article: Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging
Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging Open
View article: Spatiotemporal Control Over Circadian Rhythms With Light
Spatiotemporal Control Over Circadian Rhythms With Light Open
Circadian rhythms are endogenous biological oscillators that synchronize internal physiological processes and behaviors with external environmental changes, sustaining homeostasis and health. Disruption of circadian rhythms leads to numero…
View article: Photo-amygdalin: light-dependent control over hydrogen cyanide release and cytotoxicity
Photo-amygdalin: light-dependent control over hydrogen cyanide release and cytotoxicity Open
A photoresponsive analogue of amygdalin enables light-dependent control over hydrogen cyanide release, myoglobin cyanide binding and cytotoxicity.
View article: Introduction to photoswitches and photopharmacology
Introduction to photoswitches and photopharmacology Open
Martina Cacciarini, G. Andrew Woolley, Wiktor Szymanski and Nadja A. Simeth introduce the Organic & Biomolecular Chemistry and RSC Medicinal Chemistry cross-journal themed collection on ‘Photoswitches and Photopharmacology’.
View article: Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with <i>in situ</i> irradiation
Probing photochemically-induced dynamic transitions by magic-angle-spinning NMR combined with <i>in situ</i> irradiation Open
We demonstrate the potential of magic angle spinning NMR to probe chemical and dynamic processes during light-driven (dis)assembly and polymerisation in semi-solid samples, enabled by efficient in situ illumination by an LED light source.
View article: Bacteria-targeted imaging using vancomycin-based positron emission tomography tracers can distinguish infection from sterile inflammation
Bacteria-targeted imaging using vancomycin-based positron emission tomography tracers can distinguish infection from sterile inflammation Open
View article: Photocleavable Protecting Groups Using a Sulfite Self‐Immolative Linker for High Uncaging Quantum Yield and Aqueous Solubility
Photocleavable Protecting Groups Using a Sulfite Self‐Immolative Linker for High Uncaging Quantum Yield and Aqueous Solubility Open
Using light as an external stimulus to control (bio)chemical processes offers many distinct advantages. Most importantly, it allows for spatiotemporal control simply through operating the light source. Photocleavable protecting groups (PPG…
View article: Photocleavable Protecting Groups Using a Sulfite Self‐Immolative Linker for High Uncaging Quantum Yield and Aqueous Solubility
Photocleavable Protecting Groups Using a Sulfite Self‐Immolative Linker for High Uncaging Quantum Yield and Aqueous Solubility Open
Using light as an external stimulus to control (bio)chemical processes offers many distinct advantages. Most importantly, it allows for spatiotemporal control simply through operating the light source. Photocleavable protecting groups (PPG…
View article: Synthesis and preclinical evaluation of [18F]AlF-NODA-MP-C6-CTHRSSVVC as a PET tracer for CD163-positive tumor-infiltrating macrophages
Synthesis and preclinical evaluation of [18F]AlF-NODA-MP-C6-CTHRSSVVC as a PET tracer for CD163-positive tumor-infiltrating macrophages Open
View article: Visible and near-infrared light-induced photoclick reactions
Visible and near-infrared light-induced photoclick reactions Open
Photoclick reactions combine the advantages offered by light-driven processes, that is, non-invasive and high spatiotemporal control, with classical click chemistry and have found applications ranging from surface functionalization, polyme…
View article: Towards medical imaging of drug photoactivation: Development of light responsive magnetic resonance imaging and chemical exchange saturation transfer contrast agents
Towards medical imaging of drug photoactivation: Development of light responsive magnetic resonance imaging and chemical exchange saturation transfer contrast agents Open
In recent years, the use of light to selectively and precisely activate drugs has been developed along the fundamental concepts of photopharmacology. One of the key methods in this field relies on transiently silencing the drug activity wi…
View article: Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Highlight selection of radiochemistry and radiopharmacy developments by editorial board Open
Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. Main body This selection of highlights provid…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 21/2024
Graphical Abstract: Angew. Chem. Int. Ed. 21/2024 Open
Metal-Organic FrameworksIn their Research Article (e202319177), Lei Li, Qiang Xu et al. report a metal-organic framework-derived Zr/Ti bimetallic oxide solid solution anchored with Au nanoparticles through crystal engineering and derivatio…
View article: Multivalent probes in molecular imaging: reality or future?
Multivalent probes in molecular imaging: reality or future? Open
View article: Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography
Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography Open
View article: Triplet‐Triplet Energy Transfer: A Simple Strategy for an Efficient Visible Light‐Induced Photoclick Reaction
Triplet‐Triplet Energy Transfer: A Simple Strategy for an Efficient Visible Light‐Induced Photoclick Reaction Open
Photoclick reactions combine the advantages offered by light‐driven processes and classical click chemistry and have found applications ranging from surface functionalization, polymer conjugation, photo‐crosslinking, and protein labeling. …
View article: Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein
Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein Open
Enabling control over the bioactivity of proteins with light, along with the principles of photopharmacology, has the potential to generate safe and targeted medical treatments. Installing light sensitivity in a protein can be achieved thr…
View article: Photocontrol of the β-Hairpin Polypeptide Structure through an Optimized Azobenzene-Based Amino Acid Analogue
Photocontrol of the β-Hairpin Polypeptide Structure through an Optimized Azobenzene-Based Amino Acid Analogue Open
A family of neurodegenerative diseases, including Huntington's disease (HD) and spinocerebellar ataxias, are associated with an abnormal polyglutamine (polyQ) expansion in mutant proteins that become prone to form amyloid-like aggregates. …
View article: Getting a molecular grip on the half-lives of iminothioindoxyl photoswitches
Getting a molecular grip on the half-lives of iminothioindoxyl photoswitches Open
Molecular engineering of an ITI photoswitch, supported by DFT calculations and advanced spectroscopy, allows the half-life of its unstable state to be boosted to the levels needed for biological applications.
View article: With or without a co-solvent? highly efficient ultrafast phenanthrenequinone-electron rich alkene (PQ-ERA) photoclick reactions
With or without a co-solvent? highly efficient ultrafast phenanthrenequinone-electron rich alkene (PQ-ERA) photoclick reactions Open
The commonly used solubilizing co-solvent DMSO was found to quench the triplet state of PQ in PQ-ERA photoclick reactions. DMSO-free conditions lead to exceptionally high photoreaction quantum yields and rate constants.
View article: Modulation of the isomerization of iminothioindoxyl switches by supramolecular confinement
Modulation of the isomerization of iminothioindoxyl switches by supramolecular confinement Open
Confining iminothioindoxyl photoswitches within a supramolecular coordination cage imparts a bifurcation of the excited state isomerization pathway.
View article: The fate of the contact ion pair determines the photochemistry of coumarin-based photocleavable protecting groups
The fate of the contact ion pair determines the photochemistry of coumarin-based photocleavable protecting groups Open
Improving the efficiency of photocleavable protecting groups is crucial for their application. Here we reveal how the fate of the contact ion pair intermediate plays a key role in defining this efficiency.
View article: Cation delocalization and photo-isomerization enhance the uncaging quantum yield of a photocleavable protecting group
Cation delocalization and photo-isomerization enhance the uncaging quantum yield of a photocleavable protecting group Open
The combination of two photochemical strategies for PPG optimization in one molecule results in significant improvements in PPG photochemistry.