Weihong Tan
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View article: Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers
Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers Open
Clinical in vitro diagnosis is essential in early diagnosis and prognostic assessment, yet antibody‐based assays face limitations in multiplexity and scalability. To address the growing demand for modern molecular diagnostics, a multivalen…
View article: 2D Conjugated Polymer Nanosheets: A New Choice for Boosting Electrochemiluminescence
2D Conjugated Polymer Nanosheets: A New Choice for Boosting Electrochemiluminescence Open
The application of 2D conjugated polymers (2D CPs) in electrochemiluminescence (ECL) has been hindered due to their inherent flaws. Meanwhile, the weak ECL emission at the cathode is often ignored due to the poor conversion efficiency of O…
View article: Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy
Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy Open
The targeted delivery of mRNA to specific cell types in vivo remains a major unmet need in mRNA-based therapeutics. Conventional strategies rely on nanocarriers engineered with various modifications. However, these exogenous materials coul…
View article: A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis
A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis Open
Persisting as a major global health disparity, HPV16/18‐associated cervical carcinogenesis continues to disproportionately affect populations in resource‐limited regions with compromised screening infrastructure. While molecular detection …
View article: Engineering Lanthanide Ion-Labeled Aptamers for ICP-MS Profiling of Serum-Derived Extracellular Vesicles from Colorectal Cancer
Engineering Lanthanide Ion-Labeled Aptamers for ICP-MS Profiling of Serum-Derived Extracellular Vesicles from Colorectal Cancer Open
Membrane proteins on extracellular vesicles (EVs) derived from clinical serum samples have emerged as promising biomarkers for cancer screening, early diagnosis and prognosis. However, high-throughput profiling of multiple EV proteins with…
View article: An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates
An aptamer-drug conjugate for promising cancer therapy with comprehensive evaluation from rodents to non-human primates Open
Aptamers serve as unique targeting ligands, making aptamer-drug conjugates (ApDCs) an attractive strategy for targeted cancer therapy. This study performs a comprehensive evaluation from rodents to non-human primates (NHP) of a protein tyr…
View article: 33 Unresolved Questions in Nanoscience and Nanotechnology
33 Unresolved Questions in Nanoscience and Nanotechnology Open
Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials sc…
View article: Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution
Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution Open
Performing total RNA profiling on formalin-fixed, paraffin-embedded (FFPE) samples, the predominant sample conservation method in clinical practice, remains challenging for current spatial transcriptomics techniques. Here, we introduce Ste…
View article: Aptamer-based drug delivery for targeted therapy of imatinib-resistant gastrointestinal stromal tumor
Aptamer-based drug delivery for targeted therapy of imatinib-resistant gastrointestinal stromal tumor Open
Rationale: Gastrointestinal stromal tumors (GIST), the most common mesenchymal tumors of the gastrointestinal tract, are primarily driven by activating mutations in the KIT intracellular segment. The standard treatment with imatinib freque…
View article: OTUD3-mediated stabilization of SLC7A11 drives sunitinib resistance by suppressing ferroptosis in clear cell renal cell carcinoma
OTUD3-mediated stabilization of SLC7A11 drives sunitinib resistance by suppressing ferroptosis in clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC), as the main type of RCC was treated with tyrosine kinase inhibitor (TKI) at the late stage. While drug resistance is the main challenge for TKIs like sunitinib, and the underline mechanisms remain u…
View article: PT<sub>f</sub>‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer
PT<sub>f</sub>‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer Open
The interaction between SCAF4 and RNA polymerase II (POLR2A) is crucial for proper mRNA termination, with its dysregulation leading to truncated mRNAs and nonfunctional proteins, impairing cellular growth. Despite its potential relevance, …
View article: Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate
Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate Open
Pyroptosis is a proinflammatory programmed cell death (PCD) that is causally linked to antitumor immune responses, but the therapeutic potential of pyroptosis has been limited by the lack of tumor‐specific and controllable inducers. Here, …
View article: DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins
DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins Open
Background: Cell membrane proteins play crucial roles in signal transduction and nutrient transport. Many membrane proteins are reportedly overexpressed in cancer cells, which is closely related to cancer progression. The targeted degradat…
View article: Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins
Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins Open
Cell-membrane proteins are critical mediators of signal transduction, playing essential roles in disease occurrence and progression. The emerging LYTACs (Lysosome-targeting chimeras) technology combines drug-targeting strategies with lysos…
View article: Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera
Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera Open
Recent advances in lysosome‐targeting degradation technologies have introduced strategies to regulate therapeutic membrane proteins (MPs), potentially transforming treatment paradigms. However, challenges persist, including limited degrada…
View article: Conserved Structural Mechanism of Specific Recognition of the Histone Variant H2A.Z by the YL1 Subunit of SRCAP Chromatin-remodeling Complex
Conserved Structural Mechanism of Specific Recognition of the Histone Variant H2A.Z by the YL1 Subunit of SRCAP Chromatin-remodeling Complex Open
The SRCAP complex regulates gene transcription through chromatin remodeling, where the subunit YL1 mediates the exchange of H2A-H2B dimers with H2A.Z-H2B in the nucleosome. We determined the high-resolution (2.01 Å) crystal structure of th…
View article: Dynamic Modulation of Interactions Between Hydrophobic Tag‐Conjugated DNA Nanoprobes and Cell Membrane Facilitates ATP Imaging in the Tumor Microenvironment
Dynamic Modulation of Interactions Between Hydrophobic Tag‐Conjugated DNA Nanoprobes and Cell Membrane Facilitates ATP Imaging in the Tumor Microenvironment Open
Conjugating hydrophobic tags to oligonucleotides facilitates the swift and efficient creation of membrane‐anchored DNA nanoprobes. However, the membrane‐anchoring of these hydrophobic tag‐conjugated DNA nanoprobes (HT‐DNPs) lacks specifici…
View article: Selective Leaflet‐Anchored DNA Nanoprobes for Simultaneous Monitoring of Juxta‐Plasma Membrane Environments
Selective Leaflet‐Anchored DNA Nanoprobes for Simultaneous Monitoring of Juxta‐Plasma Membrane Environments Open
The cell membrane functions as a bidirectional interface that coordinates the selective transport of substances and information between the interior and exterior of the cell. Simultaneous monitoring of both the inner and outer local enviro…
View article: DNA‐Based Signal Circuit for Self‐Regulated Bidirectional Communication in Protocell‐Living Cell Communities
DNA‐Based Signal Circuit for Self‐Regulated Bidirectional Communication in Protocell‐Living Cell Communities Open
Developing synthetic biology tools to control cell‐to‐cell signaling can provide new capabilities to engineer cell‐cell communication and program desired cellular behaviors. As cell mimics, abiotic protocells provide an attractive opportun…
View article: Functional SELEX and Biomedical Applications of Aptamers: Beyond Molecular Recognition
Functional SELEX and Biomedical Applications of Aptamers: Beyond Molecular Recognition Open
Aptamers, developed through SELEX (systematic evolution of ligands by exponential enrichment), are generally short oligonucleotide molecules with remarkable specificity and binding affinity to diverse biological targets. These molecules ha…
View article: Functional SELEX and Biomedical Applications of Aptamers: Beyond Molecular Recognition
Functional SELEX and Biomedical Applications of Aptamers: Beyond Molecular Recognition Open
Aptamers, developed through SELEX (systematic evolution of ligands by exponential enrichment), are generally short oligonucleotide molecules with remarkable specificity and binding affinity to diverse biological targets. These molecules ha…
View article: Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery
Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery Open
Albumin‐based drug delivery system, exemplified by FDA‐approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor‐targeting capability, leading to lo…
View article: Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery
Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery Open
Albumin‐based drug delivery system, exemplified by FDA‐approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor‐targeting capability, leading to lo…