Willem M. de Vos
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View article: Akkermansia muciniphila MucT harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake
Akkermansia muciniphila MucT harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake Open
Dietary proanthocyanidins (PACs) are polyphenols that promote a healthy gut microbiome. PACs are notable for their rich catechol moieties with high affinity for iron, enabling them to interfere with pathogens' iron uptake. PACs selectively…
Quantification of pasteurized Akkermansia muciniphila MucT by flow cytometry: protocol optimization and inter-laboratory ring test Open
Akkermansia muciniphila MucT was authorized by EFSA in 2021 to be commercialized as novel food in its pasteurized form, corresponding to what it is commonly referred to as a postbiotic. As for probiotics, which are commercialized as living…
View article: Microbiome signatures for detection of colorectal lesions in population-based FIT screening
Microbiome signatures for detection of colorectal lesions in population-based FIT screening Open
The gut microbiome has been linked to colorectal cancer (CRC) development, with microbe-based classifiers distinguishing between CRC patients and healthy controls. However, there is a lack of studies addressing the utility of the microbiom…
View article: Autologous fecal microbiota capsules are safe and potentially preserve beta-cell function in individuals with type 1 diabetes
Autologous fecal microbiota capsules are safe and potentially preserve beta-cell function in individuals with type 1 diabetes Open
This study investigated the safety and feasibility of daily ingestion of autologous lyophilized fecal microbiota capsules (a-LFMCs) for preserving beta-cell function in individuals with type 1 diabetes (T1D). We evaluated a-LFMC in an open…
View article: Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging
Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging Open
People with HIV (PWH) on combination antiretroviral therapy have an elevated risk for aging-related non-AIDS comorbidities. We assessed whether HIV infection accelerates biological aging in two independent cohorts of PWH using six organ-sp…
View article: Distinct modulatory effects of high-fiber and fermented-food diets on gut microbiota, immune function, transit time, and sleep quality in a citizen science randomized controlled trial
Distinct modulatory effects of high-fiber and fermented-food diets on gut microbiota, immune function, transit time, and sleep quality in a citizen science randomized controlled trial Open
A randomized, placebo-controlled citizen science-based dietary intervention was conducted among 147 healthy adults to evaluate the effects of 8-week high dietary fiber (HDF) and high fermented food (HFF) diets on gut microbiota, immune fun…
View article: Maternal Prenatal and Postnatal Stress and Infections in Infancy
Maternal Prenatal and Postnatal Stress and Infections in Infancy Open
Aim To study maternal stress as a possible risk factor for early infections in infants in a well‐characterised, prospective infant HELMi cohort. Methods We measured maternal stress during the last trimester with questionnaires (4 items, sc…
View article: Travel to the tropics: Impact on gut microbiota
Travel to the tropics: Impact on gut microbiota Open
Travel to an LMIC significantly impacted intestinal microbiota. Individuals with high pre-travel proportions of Ruminococcaceae and Coprococcus spp. acquired a greater DEC pathotype diversity. However, no specific pre-travel microbiota pro…
View article: <i>Anaerobutyricum soehngenii</i> improves glycemic control and other markers of cardio-metabolic health in adults at risk of type 2 diabetes
<i>Anaerobutyricum soehngenii</i> improves glycemic control and other markers of cardio-metabolic health in adults at risk of type 2 diabetes Open
Anaerobutyricum soehngenii (previously Eubacterium hallii) is a butyrate-producing next-generation beneficial microbe generally recognized as safe. Several short-term intervention trials by A. soehngenii L2-7 have shown improvement of insu…
View article: Associations between infant gut microbiota and the living environment
Associations between infant gut microbiota and the living environment Open
The human gut microbiota is central to health and development of the host, and early life microbiota is affected by a range of factors that can alter the infant’s development for years to come. The role of the external, natural environment…
View article: The Aggregated Gut Viral Catalogue (AVrC): A unified resource for exploring the viral diversity of the human gut
The Aggregated Gut Viral Catalogue (AVrC): A unified resource for exploring the viral diversity of the human gut Open
The growing interest in the role of the gut virome in human health and disease, has led to several recent large-scale viral catalogue projects mining human gut metagenomes each using varied computational tools and quality control criteria.…
View article: 381. Transplantation of Maternal Intestinal Flora to the Newborn After Elective Cesarean Section - A Randomized Controlled Trial (SECFLOR)
381. Transplantation of Maternal Intestinal Flora to the Newborn After Elective Cesarean Section - A Randomized Controlled Trial (SECFLOR) Open
Background Normal microbial colonization process from the mother to the newborn is disrupted by birth by caesarean section (CS). We assess, whether in CS-delivered infants, the intestinal microbiome could be successfully and safely normali…
View article: Reconstructing ecological community dynamics from limited observations
Reconstructing ecological community dynamics from limited observations Open
Ecosystems tend to fluctuate around stable equilibria in response to internal dynamics and environmental factors. Occasionally, they enter an unstable tipping region and collapse into an alternative stable state. Our understanding of how e…
View article: Randomised double-blind placebo-controlled trial protocol to evaluate the therapeutic efficacy of lyophilised faecal microbiota capsules amended with next-generation beneficial bacteria in individuals with metabolic dysfunction-associated steatohepatitis
Randomised double-blind placebo-controlled trial protocol to evaluate the therapeutic efficacy of lyophilised faecal microbiota capsules amended with next-generation beneficial bacteria in individuals with metabolic dysfunction-associated steatohepatitis Open
Background The spectrum of metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent, affecting 30% of the world’s population, with a significant risk of hepatic and cardiometabolic complications. Different stage…
View article: Host-microbiota interactions in the infant gut revealed by daily faecal sample time series
Host-microbiota interactions in the infant gut revealed by daily faecal sample time series Open
Aim: This study aims to explore the interplay between host immune factors and gut microbiota in human infants in vivo using time-series daily stool samples and identify biomarkers of host-microbe interactions. Methods: 216 faecal samples c…
View article: 8000 Intestinimonas Butyriciproducens As A New Preventive Therapy For Type 2 Diabetes: a Proof Of Concept Randomized Controlled Trial
8000 Intestinimonas Butyriciproducens As A New Preventive Therapy For Type 2 Diabetes: a Proof Of Concept Randomized Controlled Trial Open
Disclosure: V. Antoniotti: None. M. Caputo: None. E. Mollero: None. A. Antonioli: None. S. Tini: None. M. Manfredi: None. S. Gul: None. N. Bui: None. J. Seegers: None. W. De Vos: None. G. Aimaretti: None. F. Prodam: None. Background. The i…
View article: What defines a healthy gut microbiome?
What defines a healthy gut microbiome? Open
The understanding that changes in microbiome composition can influence chronic human diseases and the efficiency of therapies has driven efforts to develop microbiota-centred therapies such as first and next generation probiotics, prebioti…
View article: A cohort study in family triads: impact of gut microbiota composition and early life exposures on intestinal resistome during the first two years of life
A cohort study in family triads: impact of gut microbiota composition and early life exposures on intestinal resistome during the first two years of life Open
Antibiotic resistance genes (ARGs) are prevalent in the infant gut microbiota and make up the intestinal resistome, representing a community ARG reservoir. This study focuses on the dynamics and persistence of ARGs in the early gut microbi…
Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes Open
This randomized, double-blind, placebo-controlled trial investigated the impact of 14-day Anaerobutyricum soehngenii L2-7 supplementation on postprandial glucose levels in 25 White Dutch males with type 2 diabetes (T2D) on stable metformin…
View article: The Aggregated Gut Viral Catalogue (AVrC): A Unified Resource for Exploring the Viral Diversity of the Human Gut
The Aggregated Gut Viral Catalogue (AVrC): A Unified Resource for Exploring the Viral Diversity of the Human Gut Open
Despite the growing interest in the role of the gut virome in human health and disease, identifying viral sequences from human gut metagenomes remains computationally challenging due to underrepresentation of viral genomes in reference dat…
View article: Omics-based analysis of <i>Akkermansia muciniphila</i> cultivation in food-grade media
Omics-based analysis of <i>Akkermansia muciniphila</i> cultivation in food-grade media Open
Background and Aim: Over the past years, the gut microbiota and its correlation to health and disease has been studied extensively. In terms of beneficial microbes, an increased interest in Akkermansia muciniphila (A. muciniphila ) has bee…