William Whiteley
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Predisposing Factors, Pathologies, and Precipitating Factors Causing Intracerebral Hemorrhage Open
Most people with spontaneous intracerebral hemorrhage (ICH) have hypertension, which is the strongest modifiable predisposing (risk) factor. However, multiple long-term medical conditions and other known predisposing factors for ICH usuall…
View article: The journey of the patients with dementia in the Peruvian health system
The journey of the patients with dementia in the Peruvian health system Open
Background Dementia is a high burden condition in many low‐ and middle‐ income countries (LMIC). However, data are limited in terms of the patients' journey to receive a dementia diagnosis and treatment. There is also a lack of guidance on…
View article: Validation and cost-effectiveness of an mHealth tool for cognitive impairment detection in Peru: protocol for the IMPACT Salud observational study
Validation and cost-effectiveness of an mHealth tool for cognitive impairment detection in Peru: protocol for the IMPACT Salud observational study Open
Introduction Dementia is a chronic and progressive neurological condition characterised by cognitive and functional impairment. It is often associated with multimorbidity and imposes a significant economic burden on healthcare systems and …
View article: Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data
Burden of cardiovascular diseases in England (2020–24): a national cohort using electronic health records data Open
British Heart Foundation Data Science Centre (Health Data Research UK).
View article: Thrombolysis With Tenecteplase for Minor Disabling Stroke
Thrombolysis With Tenecteplase for Minor Disabling Stroke Open
Importance Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective To determine whether intravenous tenecteplase improves outcomes according to US National Insti…
View article: Harnessing Routinely Collected Health Data for Global Monitoring of Stroke: Roadmap and Vision for INSPIRE-STROKE
Harnessing Routinely Collected Health Data for Global Monitoring of Stroke: Roadmap and Vision for INSPIRE-STROKE Open
Introduction: Sustainable and low-cost data systems for national and global surveillance of stroke are urgently needed to address the growing burden of stroke. Routinely collected health data (including registries and administrative data) …
View article: Hypertension in pregnancy and in midlife and the risk of dementia: prospective study of 1.3 million UK women
Hypertension in pregnancy and in midlife and the risk of dementia: prospective study of 1.3 million UK women Open
INTRODUCTION Midlife hypertension is associated with dementia risk, although uncertainties remain regarding its association with subtypes and regarding the effect of pregnancy‐related hypertension on dementia risk. METHODS In the Million W…
View article: Decades-long elevation of interferon-α drives a Sjögren disease endotype: an interdisciplinary study
Decades-long elevation of interferon-α drives a Sjögren disease endotype: an interdisciplinary study Open
SUMMARY BACKGROUND Mechanistic heterogeneity is a major obstacle to the development of effective treatment for Sjögren disease (SjD) and there is a pressing need to stratify SjD according to precision medicine principles. Aberrant activati…
Interleukin-6, C-Reactive Protein, and Vascular Recurrence After Stroke With and Without Atherosclerosis Open
BACKGROUND: Uncertainty remains whether inflammation is implicated in poststroke recurrence in patients without atherosclerosis. We evaluated the contribution of atherosclerosis status to the association between inflammatory markers and ma…
View article: Association of Covert Cerebrovascular Disease With Falls Requiring Medical Attention
Association of Covert Cerebrovascular Disease With Falls Requiring Medical Attention Open
BACKGROUND: The impact of covert cerebrovascular disease on falls in the general population is not well-known. Here, we determine the time to a first fall following incidentally detected covert cerebrovascular disease during a clinical neu…
View article: Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 395,273 people using natural language processing
Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 395,273 people using natural language processing Open
Background The relevance of covert cerebrovascular disease (CCD) in practice is uncertain, in part because estimation of risk in whole clinical populations is difficult. To address this gap, we measured clinically reported CCD in a large c…
View article: Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial
Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial Open
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with mi…
View article: Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke
Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke Open
Importance After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke is not well-known. Objective To determine the annual incidence rates and cumulative incidences of stroke up to 10 years after TIA or minor str…
View article: Long-term benefits of atorvastatin on the incidence of cardiovascular events: the ASCOT-Legacy 20-year follow-up
Long-term benefits of atorvastatin on the incidence of cardiovascular events: the ASCOT-Legacy 20-year follow-up Open
Aims Cardiovascular (CV) deaths were reduced by atorvastatin during a 16-year follow-up of participants in the Anglo-Scandinavian Cardiac Outcomes Trial-lipid-lowering arm. We now extend these observations over 20 years and report both non…
View article: Automated neuroradiological support systems for multiple cerebrovascular disease markers — A systematic review and meta-analysis
Automated neuroradiological support systems for multiple cerebrovascular disease markers — A systematic review and meta-analysis Open
Cerebrovascular diseases (CVD) can lead to stroke and dementia. Stroke is the second leading cause of death world wide and dementia incidence is increasing by the year. There are several markers of CVD that are visible on brain imaging, in…
View article: Blood pressure variability: a review
Blood pressure variability: a review Open
Blood pressure variability (BPV) predicts cardiovascular events independent of mean blood pressure. BPV is defined as short-term (24-h), medium or long- term (weeks, months or years). Standard deviation, coefficient of variation and variat…
View article: Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis
Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis Open
Background Thrombosis with thrombocytopenia syndrome is a rare condition known to occur spontaneously or after heparin use. With the advent of COVID-19 vaccines during the pandemic, thrombosis with thrombocytopenia syndrome cases emerged p…
View article: Assessing the role of vascular risk factors in dementia: Mendelian randomization meta-analysis and comparison with observational estimates
Assessing the role of vascular risk factors in dementia: Mendelian randomization meta-analysis and comparison with observational estimates Open
Background Although observational studies demonstrate that higher levels of vascular risk factors are associated with an increased risk of dementia, these associations might be explained by confounding or other biases. Mendelian randomizat…
View article: Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review
Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review Open
Background Dementia is a global health priority with significant challenges due to its complex nature and increasing prevalence. Health systems worldwide struggle to address chronic conditions like dementia, often providing fragmented care…
View article: Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy
Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy Open
Chronically elevated type I interferons (−β and -α) can induce atherosclerosis and autoimmunity but whether this link translates into adverse events in interferon-β users with multiple sclerosis is unknown. We therefore aimed to determine …
View article: Risks of major arterial and venous thrombotic diseases after hospitalisation for influenza, pneumonia, and COVID-19: A population-wide cohort in 2.6 million people in Wales
Risks of major arterial and venous thrombotic diseases after hospitalisation for influenza, pneumonia, and COVID-19: A population-wide cohort in 2.6 million people in Wales Open
OBJECTIVE: Pneumonia, influenza, COVID-19, and other common infections might increase the risk of thrombotic events acutely through an interaction between inflammation and the thrombotic system. The long-term risks of arterial and venous t…