Wade Wang
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Weighing the DNA content of Adeno-Associated Virus vectors with zeptogram precision using nanomechanical resonators Open
Quantifying the composition of viral vectors used in vaccine development and gene therapy is critical for assessing their functionality. Adeno-Associated Virus (AAV) vectors, which are the most widely used viral vectors for in-vivo gene th…
Back Cover: Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing (Angew. Chem. Int. Ed. 7/2020) Open
Layer-by-layer nanoparticles functionalized with protease-responsive peptide biomarkers and loaded with siRNA mediate noninvasive urinary-based diagnostics in mouse models of three different cancers with simultaneous gene silencing in flan…
Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing Open
Layer‐by‐layer nanoparticles (NPs) are modular drug delivery vehicles that incorporate multiple functional materials through sequential deposition of polyelectrolytes onto charged nanoparticle cores. Herein, we combined the multicomponent …
View article: Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination
Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination Open
Significance Vaccine kinetics, the timing of antigen and/or adjuvant delivery to lymphoid organs, have recently been shown to substantially influence immune responses to subunit vaccines, but strategies to control vaccine kinetics in a cli…
Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing Open
The delivery of small interfering RNA (siRNA) remains a major hurdle for the clinical translation of RNA interference (RNAi) therapeutics. Because of its low valency and rigid nature, siRNA typically requires high excesses of cationic deli…
Hydrolysis resistant functional polypeptide scaffold for biomaterials Open
Various methods are investigated to prepare a versatile biopolymer.
View article: Polyamine‐Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery
Polyamine‐Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery Open
Messenger RNA (mRNA) represents a promising class of nucleic acid drugs. Although numerous carriers have been developed for mRNA delivery, the inefficient mRNA expression inside cells remains a major challenge. Inspired by the dependence o…
View article: Polyamine‐Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery
Polyamine‐Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery Open
Messenger RNA (mRNA) represents a promising class of nucleic acid drugs. Although numerous carriers have been developed for mRNA delivery, the inefficient mRNA expression inside cells remains a major challenge. Inspired by the dependence o…
View article: Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery
Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery Open
Messenger RNA (mRNA) represents a promising class of nucleic-acid-based therapeutics. While numerous nanocarriers have been developed for mRNA delivery, the inherent labile nature of mRNA results in a very low transfection efficiency and p…
Synthesis and characterization of photobase generators for pitch division photolithography Open
Pitch division lithography is a resolution enhancing technique that doubles the resolution of features in a photomask when recorded in photoresist without imposing costly additional steps or demanding manufacturing equipment. In convention…