Wael M. El‐Sayed
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View article: Large diameter zinc oxide nanoparticles reduced testicular CYP17A1 and viability and elevated testicular inflammation in adult male rats
Large diameter zinc oxide nanoparticles reduced testicular CYP17A1 and viability and elevated testicular inflammation in adult male rats Open
Background The rapid advancement of nanotechnology has led to growing interest in its effects on health. This study investigates the impact of zinc oxide nanoparticles (ZnO NPs) on male rats’ reproductive health by assessing two different …
View article: Tilianin: pharmacological potential, mechanisms of action, and future perspectives in traditional and modern medicine
Tilianin: pharmacological potential, mechanisms of action, and future perspectives in traditional and modern medicine Open
View article: Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies
Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies Open
Medulloblastomas are the most common malignant pediatric brain tumors, representing approximately 20% of the central nervous system cancers in children. These tumors are highly heterogeneous and classified into four molecular subgroups-WNT…
View article: Targeting meningiomas: advances in molecular pathways, drug repurposing, and precision therapy
Targeting meningiomas: advances in molecular pathways, drug repurposing, and precision therapy Open
Background Meningiomas are the most common primary intracranial tumors in adults, accounting for more than one-third of brain neoplasms. Most are slow-growing, but higher-grade subtypes (WHO grades II–III) often recur, invade surrounding s…
View article: Rhamnetin is a multifaceted flavonoid with potential in cancer therapy: current insights and future directions
Rhamnetin is a multifaceted flavonoid with potential in cancer therapy: current insights and future directions Open
Background Cancer remains a major global health burden, contributing significantly to illness and death worldwide. Although current treatments such as chemotherapy, radiation therapy, and surgery have improved patient outcomes, they are fr…
View article: Integrating artificial intelligence with nanodiagnostics for early detection and precision management of neurodegenerative diseases
Integrating artificial intelligence with nanodiagnostics for early detection and precision management of neurodegenerative diseases Open
Background Neurodegenerative diseases—including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS)—as well as autoimmune disorders with neurodegenerative features such as multiple sclerosis (MS), present an escalating global…
View article: Nuclear receptors in metabolic, inflammatory, and oncologic diseases: mechanisms, therapeutic advances, and future directions
Nuclear receptors in metabolic, inflammatory, and oncologic diseases: mechanisms, therapeutic advances, and future directions Open
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that regulate gene expression in response to metabolic, hormonal, and environmental signals. These receptors play a critical role in metabolic homeostasis,…
View article: Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways
Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways Open
Background Chronic kidney disease (CKD) poses significant health challenges worldwide, with limited effective natural therapies targeting its progression through antioxidant mechanisms. Although gum acacia (GA) has shown general metabolic …
View article: Quercetin alleviates gold nanoparticles-induced hepato-renal toxicity: roles of oxidative stress, inflammation, and histopathology
Quercetin alleviates gold nanoparticles-induced hepato-renal toxicity: roles of oxidative stress, inflammation, and histopathology Open
Background Gold nanoparticles (AuNPs) are increasingly used in biomedical applications, but concerns regarding their potential toxicity, particularly in the liver and kidneys, have been raised. This study aims to investigate the protective…
View article: Harnessing the Microbiome: CRISPR-Based Gene Editing and Antimicrobial Peptides in Combating Antibiotic Resistance and Cancer
Harnessing the Microbiome: CRISPR-Based Gene Editing and Antimicrobial Peptides in Combating Antibiotic Resistance and Cancer Open
View article: Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations
Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations Open
View article: Comparative therapeutic and prophylactic efficacy of ethanol and water extracts of ginger in alleviating acetaminophen-induced hepatotoxicity and dyslipidemia
Comparative therapeutic and prophylactic efficacy of ethanol and water extracts of ginger in alleviating acetaminophen-induced hepatotoxicity and dyslipidemia Open
Background: Acetaminophen (APAP) overdose, common during pandemics like COVID-19, causes liver injury through oxidative stress. Ginger, known for its antioxidant properties, is suggested as a potential natural remedy. Objective: This study…
View article: Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis
Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis Open
View article: A new cadinane-type sesquiterpenoid glucoside from <i>Centaurea alexandrina</i>
A new cadinane-type sesquiterpenoid glucoside from <i>Centaurea alexandrina</i> Open
A new cadinane-type sesquiterpene glucoside, 10α-hydroxy, 1α(H), 6β(H), 7β(H), 8β(H)-cadinane-4-en-8-O-β-D-glucoside (1) as well as, 2 known analogues [sinaicin (2)- linichlorinA (…
View article: Feeding Categorisation of some Caeliferan and Ensiferan species (Insecta: Orthoptera) collected from selected grasslands in Sendai City, Japan
Feeding Categorisation of some Caeliferan and Ensiferan species (Insecta: Orthoptera) collected from selected grasslands in Sendai City, Japan Open
Although orthopteran species have often been regarded as polyphagous herbivores, most of them show variable degrees of diet selectivity and particular food preferences. Still some species possess peculiar feeding categories which need furt…
View article: The Phytochemical Profile of the Petroleum Ether Extract of Purslane Leaves and Its Anticancer Effect on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None (NNK)-Induced Lung Cancer in Rats
The Phytochemical Profile of the Petroleum Ether Extract of Purslane Leaves and Its Anticancer Effect on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None (NNK)-Induced Lung Cancer in Rats Open
Lung cancer is a prevalent and very aggressive sickness that will likely claim 1.8 million lives by 2022, with an estimated 2.2 million additional cases expected worldwide. The goal of the current investigation was to determine whether pet…
View article: The bacterial microbiome and cancer: development, diagnosis, treatment, and future directions
The bacterial microbiome and cancer: development, diagnosis, treatment, and future directions Open
View article: Demographic, Clinical and Angiographic Profile of Patients Scheduled for Coronary Intervention in Kalyoboia Governorate
Demographic, Clinical and Angiographic Profile of Patients Scheduled for Coronary Intervention in Kalyoboia Governorate Open
View article: Chia Seed (Salvia hispanica) Attenuates Chemically Induced Lung Carcinomas in Rats through Suppression of Proliferation and Angiogenesis
Chia Seed (Salvia hispanica) Attenuates Chemically Induced Lung Carcinomas in Rats through Suppression of Proliferation and Angiogenesis Open
In 2022, 2.5 million cases of lung cancer were diagnosed, resulting in 1.8 million deaths. These statistics have motivated us to introduce a new natural product which is feasible in lung cancer therapies. This comprehensive study was perfo…
View article: Correction: Phytochemical and biological investigation of Astragalus Caprinus L
Correction: Phytochemical and biological investigation of Astragalus Caprinus L Open
View article: Zinc Oxide Nanoparticles Induced Testicular Toxicity Through Inflammation and Reducing Testosterone and Cell Viability in Adult Male Rats
Zinc Oxide Nanoparticles Induced Testicular Toxicity Through Inflammation and Reducing Testosterone and Cell Viability in Adult Male Rats Open
Zinc oxide nanoparticles (ZnO NPs) have wide applications in daily life. Therefore, there is growing interest in the potential harmful impacts of these particles on human health. The present study was conducted to investigate the potential…
View article: Phytochemical and biological investigation of Astragalus Caprinus L
Phytochemical and biological investigation of Astragalus Caprinus L Open
Background cultivated and wild plants are used to treat different ailments. The Astragalus genus is found in temperate and dry climates; thus, it is found in Egypt and the arab world. Astragalus caprinus has a good amount of bioactive chem…
View article: Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase
Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase Open
The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2,3-c]pyrazolopyrimidines were synth…
View article: HOMA-IR INDEX IN INDUSTRIAL SHIFT WORKERS, A PRELIMINARY STUDY
HOMA-IR INDEX IN INDUSTRIAL SHIFT WORKERS, A PRELIMINARY STUDY Open
There is strong evidence suggesting a probable association between shift work (SW) and insulin resistance (IR).Hence, it is crucial to evaluate this factor in therapeutic and preventive interventions.In a comparative cross-sectional study,…
View article: Quercetin and l-Arginine Ameliorated the Deleterious Effects of Copper Oxide Nanoparticles on the Liver of Mice Through Anti-inflammatory and Anti-apoptotic Pathways
Quercetin and l-Arginine Ameliorated the Deleterious Effects of Copper Oxide Nanoparticles on the Liver of Mice Through Anti-inflammatory and Anti-apoptotic Pathways Open
The widespread use and applications of copper oxide nanoparticles (CuO NPs) in daily life make human exposure to these particles inevitable. This study was carried out to investigate the deteriorations in hepatic and serum biochemical para…
View article: Chenopodium murale Juice Shows Anti-Fungal Efficacy in Experimental Oral Candidiasis in Immunosuppressed Rats in Relation to Its Chemical Profile
Chenopodium murale Juice Shows Anti-Fungal Efficacy in Experimental Oral Candidiasis in Immunosuppressed Rats in Relation to Its Chemical Profile Open
Chenopodium murale (Syn. Chenopodiastrum murale) (amaranthaceae) is used in the rural Egypt to treat oral ulcers in newborn children. The current study aimed to discover new natural products suitable for treating candidiasis disease with m…
View article: miRNome of Child A hepatocellular carcinoma in Egyptian patients
miRNome of Child A hepatocellular carcinoma in Egyptian patients Open
Introduction Hepatocellular carcinoma (HCC) has different etiologies that contribute to its heterogeneity. In regards to the number of HCC patients, Egypt ranks third in Africa and fifteenth worldwide. Despite significant advancements in H…
View article: 1,4,9,9-tetramethyloctahydro-4,7-(epoxymethano)azulen-5(1H)-one, a natural product as a potential inhibitor of COVID-19: Extraction, crystal structure, and virtual screening approach
1,4,9,9-tetramethyloctahydro-4,7-(epoxymethano)azulen-5(1H)-one, a natural product as a potential inhibitor of COVID-19: Extraction, crystal structure, and virtual screening approach Open
In the present work, we describe the extraction of a natural product namely 1,4,9,9-tetramethyloctahydro-4,7-(epoxymethano)azulen-5(1H)-one, and its structure was confirmed by single crystal X-ray diffraction analysis. The conformations of…
View article: Combining Ability and Classification of New Thirteen Yellow Maize Inbred Lines (Zea mays L.) Using Line X Tester Mating Design Across Three Locations
Combining Ability and Classification of New Thirteen Yellow Maize Inbred Lines (Zea mays L.) Using Line X Tester Mating Design Across Three Locations Open
Thirteen new promising yellow maize inbred lines were top crossed with three inbred lines as testers, i.e., Sd.3, Sd.42 and Mallawy.5035 at Sids Agricultural Research Station during 2020 growing season.In the growing season 2021, the 39 to…
View article: New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile
New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile Open
Compound 19 arrested the MCF-7 cells at the G2/M phase probably through inhibition of CDK1 and elicited apoptosis. It did not violate Lipinski's rule of five and has a low blood brain barrier penetration and high intestinal absorption.