Wafaa Jamal
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View article: EXPLORING MICRORNA EXPRESSION PATTERNS IN EARLY DETECTION AND PROGRESSION OF HEPATOCELLULAR CARCINOMA- SYSTEMATIC REVIEW
EXPLORING MICRORNA EXPRESSION PATTERNS IN EARLY DETECTION AND PROGRESSION OF HEPATOCELLULAR CARCINOMA- SYSTEMATIC REVIEW Open
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with most cases diagnosed at an advanced stage due to limitations in current diagnostic tools. Traditional biomarkers such as alpha-fetopr…
View article: <i>Salmonella enterica</i> serotypes causing infection in Kuwait during 2018–2021, determined by multi-locus sequence typing or whole genome sequencing
<i>Salmonella enterica</i> serotypes causing infection in Kuwait during 2018–2021, determined by multi-locus sequence typing or whole genome sequencing Open
Salmonellosis due to non-typhoidal Salmonellae (NTS) is a zoonotic infection that has epidemiological uniqueness in different settings. The current study aimed to determine the serotypes and the genetic diversity of human Salmonella enteri…
View article: Pulmonary Amebiasis Leading to Multicystic Empyema
Pulmonary Amebiasis Leading to Multicystic Empyema Open
Pulmonary amebiasis is a rare but serious condition that can lead to multicystic empyema. Early recognition and prompt treatment with surgical intervention and metronidazole are crucial. This case highlights the importance of considering a…
View article: Application to achievement: association between pre-admission factors, admission scores, and medical students’ performance
Application to achievement: association between pre-admission factors, admission scores, and medical students’ performance Open
Higher scores on medical college admission tests can predict medical students' academic achievement during undergraduate studies. Understanding the specific test components associated with students' success can refine the selection process…
View article: Recent advances in gene-editing approaches for tackling antibiotic resistance threats: a review
Recent advances in gene-editing approaches for tackling antibiotic resistance threats: a review Open
Antibiotic resistance, a known global health challenge, involves the flow of bacteria and their genes among animals, humans, and their surrounding environment. It occurs when bacteria evolve and become less responsive to the drugs designat…
View article: Antimicrobial Resistance Profiles of Pseudomonas aeruginosa in the Arabian Gulf Region Over a 12-Year Period (2010–2021)
Antimicrobial Resistance Profiles of Pseudomonas aeruginosa in the Arabian Gulf Region Over a 12-Year Period (2010–2021) Open
Objectives To evaluate literature from a 12-year period (2010–2021) on the antimicrobial resistance profile of Pseudomonas aeruginosa from the Arabian Gulf countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates…
View article: The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in <i>Clostridioides difficile</i>
The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in <i>Clostridioides difficile</i> Open
Background: Clostridioides difficile is an important cause of healthcare-associated diarrhea. Several anti- microbial agents are known to promote C. difficile infection (CDI). The impact of various concentrations of ampicillin (AMP), cefot…
View article: Cracking the Code: Unveiling the Diversity of Carbapenem-Resistant Klebsiella pneumoniae Clones in the Arabian Peninsula through Genomic Surveillance
Cracking the Code: Unveiling the Diversity of Carbapenem-Resistant Klebsiella pneumoniae Clones in the Arabian Peninsula through Genomic Surveillance Open
The rise of antimicrobial resistance is a global challenge that requires a coordinated effort to address. In this study, we examined the genetic similarity of carbapenem-resistant Klebsiella pneumoniae (CRKP) in countries belonging to the …
View article: Elucidating the virulence genes harboured by carbapenemase- and non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae rectal isolates from patients admitted to intensive care units using whole-genome sequencing in Kuwait
Elucidating the virulence genes harboured by carbapenemase- and non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae rectal isolates from patients admitted to intensive care units using whole-genome sequencing in Kuwait Open
Introduction. Klebsiella pneumoniae is a Gram-negative pathogen responsible for community- and nosocomial-acquired infections. The presence of an accessory genome determines the bacterial pathogenicity and the host immune response, and thu…
View article: Seroprevalence of toxocariasis among allergic patients in Kuwait and its association with eosinophilia
Seroprevalence of toxocariasis among allergic patients in Kuwait and its association with eosinophilia Open
Toxocariasis is a worldwide helminthic infection which is transmitted from infected dogs and cats and has been associated with peripheral blood eosinophilia. The Centers for Disease Control and Prevention (CDC) placed toxocariasis among th…
View article: Etiology and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Children in a General Hospital in Kuwait: A 5-Year Retrospective Study
Etiology and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Children in a General Hospital in Kuwait: A 5-Year Retrospective Study Open
Objective: The aim of this study was to determine the bacterial profile and prevalence of antibiotic resistance patterns of uropathogens, as well as to evaluate the problem with extended-spectrum β-lactamases (ESBLs)-producing isolates, ca…
View article: Epidemiology, Serogroups and Resistance of Salmonella During a 15-Year Period (2006–2020) in Kuwait
Epidemiology, Serogroups and Resistance of Salmonella During a 15-Year Period (2006–2020) in Kuwait Open
Continuous surveillance of Salmonella and its antimicrobial resistance is important for antibiotic policy formulation for invasive Salmonella infections.
View article: Evaluation of the <i>in vitro</i> activity of ceftaroline, ceftazidime/avibactam and comparator antimicrobial agents against clinical isolates from paediatric patients in Kuwait: ATLAS data 2012–19
Evaluation of the <i>in vitro</i> activity of ceftaroline, ceftazidime/avibactam and comparator antimicrobial agents against clinical isolates from paediatric patients in Kuwait: ATLAS data 2012–19 Open
Objectives To report antimicrobial resistance data for Gram-positive and Gram-negative pathogens isolated from paediatric patients in three hospitals in Kuwait during 2012–19. Methods In vitro activity of antimicrobials against isolates fr…
View article: Molecular characterization of metronidazole resistant Bacteroides strains from Kuwait
Molecular characterization of metronidazole resistant Bacteroides strains from Kuwait Open
Eleven metronidazole resistant Bacteroides and one newly classified Phocaeicola dorei strain from Kuwait were investigated for their resistance mechanisms and the emergence of their resistant plasmids. All but one strain harbored nimE gene…
View article: Prevalence of carbapenem-resistant Enterobacteriaceae and emergence of high rectal colonization rates of blaOXA-181-positive isolates in patients admitted to two major hospital intensive care units in Kuwait
Prevalence of carbapenem-resistant Enterobacteriaceae and emergence of high rectal colonization rates of blaOXA-181-positive isolates in patients admitted to two major hospital intensive care units in Kuwait Open
Background Fecal colonization by carbapenem-resistant Enterobacteriaceae (CRE) can be the main reservoir for transmission of these resistant organisms especially in the Intensive Care Units (ICUs). Aim This study was conducted to evaluate …
View article: Prevalence of target anaerobes associated with chronic periodontitis
Prevalence of target anaerobes associated with chronic periodontitis Open
Introduction. Periodontal diseases are a group of chronic infections that destroy tissues surrounding and supporting the teeth. Data on the anaerobes associated with periodontal infections in Kuwait is lacking. Aim. To investigate the targ…
View article: 535. Multicenter Study of the Prevalence of Rectal Colonization by Carbapenem-Resistant Enterobacteriaceae in Patients Admitted to the Intensive Care Units of 7 Major Hospitals in Kuwait
535. Multicenter Study of the Prevalence of Rectal Colonization by Carbapenem-Resistant Enterobacteriaceae in Patients Admitted to the Intensive Care Units of 7 Major Hospitals in Kuwait Open
Background The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become an important epidemiological change in infectious diseases in the last 10 years. The gut is an important reservoir for these isolates thereby creating an …
View article: 655. Antimicrobial Susceptibility and Prevalence of Extra-intestinal Enterotoxigenic <i>Bacteroides fragilis</i> Among a 5-Year Collection of Isolates Causing Sepsis in Kuwait
655. Antimicrobial Susceptibility and Prevalence of Extra-intestinal Enterotoxigenic <i>Bacteroides fragilis</i> Among a 5-Year Collection of Isolates Causing Sepsis in Kuwait Open
BACKGROUND: Bacteroides fragilis is commonly associated with bacteremia, soft-tissues, intra-abdominal infections and abscesses. Enterotoxigenic (BFT) strains have emerged as important etiological cause of diarrhea in children and adults. …
View article: Contribution of horizontal gene transfer to the emergence of VIM-4 carbapenemase producer Enterobacteriaceae in Kuwait
Contribution of horizontal gene transfer to the emergence of VIM-4 carbapenemase producer Enterobacteriaceae in Kuwait Open
Carbapenem-resistant Enterobacteriaceae encountered in countries of the Arabian Peninsula usually produce OXA-48-like and New Delhi metallo-beta-lactamases (NDM) carbapenemases. However, a temporary increase in VIM-4-producing, clonally un…
View article: Overwhelming Streptococcus pyogenes sepsis in an elderly patient with septic arthritis
Overwhelming Streptococcus pyogenes sepsis in an elderly patient with septic arthritis Open
GAS remains penicillin sensitive most of the time but prompt appropriate antibiotic therapy is very crucial to survival.
View article: The Prevalence of Extended-Spectrum β-lactamase (ESBL) and Carbapenem-Resistant Enterobacteriaceae (CRE) Isolates in Positive Blood Cultures of Patients in A Teaching Hospital in Kuwait Over A 2-year Period
The Prevalence of Extended-Spectrum β-lactamase (ESBL) and Carbapenem-Resistant Enterobacteriaceae (CRE) Isolates in Positive Blood Cultures of Patients in A Teaching Hospital in Kuwait Over A 2-year Period Open
Extended spectrum β-lactamase (ESBL)-producing organisms and carbapenem resistant Enterobacteriaceae (CRE) pose unique challenges to clinical microbiologists, infectious diseases physicians, infection control professionals and antibacteria…
View article: The Burden of Acinetobacter baumannii in the Intensive Care Unit of a Teaching Hospital in Kuwait Over a 3-Year Period
The Burden of Acinetobacter baumannii in the Intensive Care Unit of a Teaching Hospital in Kuwait Over a 3-Year Period Open
Acinetobacter baumannii is often endemic in several ICUs worldwide. Once it is established, it is difficult to eradicate. This study was undertaken to determine the burden of multi-drug-resistant A. baumannii infections in ICU of Mubarak h…
View article: Surveillance of Antibiotic Resistance among Hospital- and Community-Acquired Toxigenic Clostridium difficile Isolates over 5-Year Period in Kuwait
Surveillance of Antibiotic Resistance among Hospital- and Community-Acquired Toxigenic Clostridium difficile Isolates over 5-Year Period in Kuwait Open
Clostridium difficile infection (CDI) is a leading and an important cause of diarrhea in a healthcare setting especially in industrialized countries. Community-associated CDI appears to add to the burden on healthcare setting problems. The…
View article: High Prevalence of New Delhi Metallo-β-Lactamase-1 (NDM-1) Producers among Carbapenem-Resistant Enterobacteriaceae in Kuwait
High Prevalence of New Delhi Metallo-β-Lactamase-1 (NDM-1) Producers among Carbapenem-Resistant Enterobacteriaceae in Kuwait Open
The aim of the study was to determine the prevalence of New Delhi metallo-β lactamase-1 (NDM-1) producing Enterobacteriaceae in Kuwait over a one year period. Consecutive Enterobacteriaceae isolates with reduced susceptibility to carbapene…
View article: Comparative In Vitro Activity of Ceftaroline Against Gram-Negative and Gram-Positive Clinically Significant Bacterial Isolates From Patients in a Teaching Hospital.
Comparative In Vitro Activity of Ceftaroline Against Gram-Negative and Gram-Positive Clinically Significant Bacterial Isolates From Patients in a Teaching Hospital. Open
Background.Ceftaroline is a novel oxyimino cephalosporin with broad-spectrum bactericidal activities against gram-positive and gram-negative bacteria.It was approved by the US Food and Drug Administration (FDA) in 2010 for the treatment of…
View article: Abstracts of Award-Winning Posters, 21st Annual Health Sciences Poster Conference, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait, May 2-4, 2016
Abstracts of Award-Winning Posters, 21st Annual Health Sciences Poster Conference, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait, May 2-4, 2016 Open
croscopy.Data were analyzed with one-way ANOVA followed by Bonferroni's multiple comparison tests.Results: I + MAO-B-I treatment showed significant improvement in sensory and motor tests (hopping reflex, hot plate test, tail flick test, ex…
View article: Characteristics of the major clones encountered.
Characteristics of the major clones encountered. Open
NT = nontypable* in one strain the ctxM, in the other one the armA gene co-transferred with the NDM plasmidCharacteristics of the major clones encountered.