Waheba Elsayed
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View article: Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils
Type II topoisomerases shape multi-scale 3D chromatin folding in regions of positive supercoils Open
Type II topoisomerases (TOP2s) resolve torsional stress accumulated during various cellular processes and are enriched at chromatin loop anchors and topologically associated domain (TAD) boundaries, where, when trapped, can lead to genomic…
View article: RESPONSE OF THREE CYCLES OF S1 RECURRENT SELECTION FOR GRAIN YIELD IN MAIZE POPULATION SAKHA 14
RESPONSE OF THREE CYCLES OF S1 RECURRENT SELECTION FOR GRAIN YIELD IN MAIZE POPULATION SAKHA 14 Open
The new white composite maize population Sk14 was developed in Sakha Research Station, Egypt. This population which showed heterotic behavior was subjected to three cycles of S1 recurrent selection to improve yielding potentiality. The thr…
View article: Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661–PTPN11 mRNA Axis
Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661–PTPN11 mRNA Axis Open
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in Egypt. A deep understanding of the molecular events occurring in HCC can facilitate the development of novel diagnostic and/or therapeutic approaches. In the pres…
View article: High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice
High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice Open
Cancer-causing mutations often arise from inappropriate DNA repair, yet acute exposure to DNA damage is widely used to treat cancer. The challenge remains in how to specifically induce excessive DNA damage in cancer cells while minimizing …
View article: Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1
Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 Open
Camptothecin (CPT), a topoisomerase I (TOP1) inhibitor, exhibits anti-tumor activity against a wide range of tumors. Redundancy of TOP1-mediated repair mechanisms is a major challenge facing the efficiency of TOP1-targetting therapies. Thi…