Muhammad Akhtar
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View article: Population-scale cross-sectional observational study for AI-powered TB screening on one million CXRs
Population-scale cross-sectional observational study for AI-powered TB screening on one million CXRs Open
Traditional tuberculosis (TB) screening involves radiologists manually reviewing chest X-rays (CXR), which is time-consuming, error-prone, and limited by workforce shortages. Our AI model, AIRIS-TB (AI Radiology In Screening TB), aims to a…
View article: Structural and functional insights of starch processing α-amylase from hyperthermophilic archaeon Pyrococcus abyssi
Structural and functional insights of starch processing α-amylase from hyperthermophilic archaeon Pyrococcus abyssi Open
The genomic screening of hyper-thermophilic Pyrococcus abyssi showed uncharacterized novel α-amylase sequences. Homology modelling analysis revealed that the α-amylase from P. abyssi consists of an N-terminal GH57 catalytic domain, α-amyla…
View article: Structural and functional characterization of novel thermostable α-amylase (PaAFG) from hyperthermophilic archaeon Pyrococcus abyssi
Structural and functional characterization of novel thermostable α-amylase (PaAFG) from hyperthermophilic archaeon Pyrococcus abyssi Open
Amylases are biologically active enzymes that can hydrolyze starch to produce dextrin, glucose, maltose, and oligosaccharides.The amylases contribute approximately 30% to the global industrial enzyme market.The globally produced amylases a…
View article: Alpha-2-Macroglobulin and Alpha-2-HS Glycoprotein are Potential Markers of Renal Cell Carcinoma: An Insight from Proteome Profile of Cancer Tissues
Alpha-2-Macroglobulin and Alpha-2-HS Glycoprotein are Potential Markers of Renal Cell Carcinoma: An Insight from Proteome Profile of Cancer Tissues Open
CPEB3 (cytoplasmic polyadenylation element binding protein 3) is a key factor that controls poly A tail extension during translation, exhibiting a tumor suppressor effect in several kinds of tumors.However, its expression characteristics a…
View article: Exploration of computational approaches to predict the structural features and recent trends in α‐amylase production for industrial applications
Exploration of computational approaches to predict the structural features and recent trends in α‐amylase production for industrial applications Open
Amylases are biologically active enzymes that can hydrolyze starch to produce dextrin, glucose, maltose, and oligosaccharides. The amylases contribute approximately 30% to the global industrial enzyme market. The globally produced amylases…
View article: Coronary Artery to Pulmonary Artery Fistula: A Congenital Rare Defect in Adult. How was it Managed?-A Case Report
Coronary Artery to Pulmonary Artery Fistula: A Congenital Rare Defect in Adult. How was it Managed?-A Case Report Open
Coronary artery fistula (CAF) is a rare anatomic abnormality of the coronary arteries that results from abnormal communication between a coronary artery and either the chambers of the heart or the great vessels that bypass the myocardial c…
View article: In Silico Evaluation of Expressed TB Fusion CFP10-ESAT-6 Reveals Promising Diagnostic and Therapeutic Potential
In Silico Evaluation of Expressed TB Fusion CFP10-ESAT-6 Reveals Promising Diagnostic and Therapeutic Potential Open
Tuberculosis (TB) an opportunistic disease still remains a major cause of death globally after COVID-19 pandemic and HIV. Enhanced microbial resistance to therapeutic drugs has paved way to introducing new vaccines for prophylactic control…
View article: Increased Turnover of Beta 2 Microglobulin in Circulation serves as Diagnostic and Prognostic Marker for Malignant Lymphoma; A Case Control Predictive Model for Lymphoma Diagnosis
Increased Turnover of Beta 2 Microglobulin in Circulation serves as Diagnostic and Prognostic Marker for Malignant Lymphoma; A Case Control Predictive Model for Lymphoma Diagnosis Open
Indolent and aggressive hematopoietic cancer shed lot of Beta 2 microglobulin in interstitial fluid thus increasing the level of B2M in hematological malignancies. Objectives: To set forward B2M as potential biomarker for the detection and…
View article: Comparative Analysis of Ultrasound and MRI in Detecting Endometriosis among Pakistani Women
Comparative Analysis of Ultrasound and MRI in Detecting Endometriosis among Pakistani Women Open
Background: Endometriosis is a persistent gynecological disease that greatly affects a woman’s quality of life and reproductive health. Diagnosis is increasingly done using such non-invasive imaging modalities as transvaginal ultrasound (T…
View article: Pre-Operative Evaluation of Petrous Temporal Bone Pathologies by CT and MRI in Cochlear Implant Candidates
Pre-Operative Evaluation of Petrous Temporal Bone Pathologies by CT and MRI in Cochlear Implant Candidates Open
Aim: To evaluate pathologies of the petrous temporal bone in cochlear implant candidates on CT and MRI preoperatively. Methods: A cross-sectional study was conducted at Combined Military Hospital Lahore from Jan 2014 to April 2016. 163 can…
View article: SPEECH AND LANGUAGE IMPAIRMENT AFTER CHILDHOOD ARTERIAL ISCHEMIC STROKE
SPEECH AND LANGUAGE IMPAIRMENT AFTER CHILDHOOD ARTERIAL ISCHEMIC STROKE Open
Objective: Investigate the potential predictors’ dysarthria and dyspraxia of speech and language impairment after childhood stroke.
Study Design: Cross sectional study
Place and duration of study: Study was conducted in the department of…
View article: Hounsfield Units (HU) as a Predictor of Stone Clearance after Percutaneous Nephrolithotomy (PCNL)
Hounsfield Units (HU) as a Predictor of Stone Clearance after Percutaneous Nephrolithotomy (PCNL) Open
Objective: To compare the outcomes of percutaneous nephrolithotomy (PCNL) in patients with renal stones with high (≥700) versus low (<700) HU. Patients and Methods: A total of 200 patients having age 18 to 60 years, with diagnosis of unila…
View article: Frequency of Ureteral Stent Encrustations in a Urology Unit of Tertiary Care Hospital
Frequency of Ureteral Stent Encrustations in a Urology Unit of Tertiary Care Hospital Open
Objective: To determine the frequency of encrustations of ureteral stents in a tertiary care hospital of Pakistan. Patients and Methods: In this study we included 150 patients of Urology Unit of Ibn e Sina Hospital and Research Institute M…
View article: Stone Clearance Rate in Patients Treated with Percutaneous Nephrolithotomy versus Open Surgery for the Management of Staghorn Renal Calculi
Stone Clearance Rate in Patients Treated with Percutaneous Nephrolithotomy versus Open Surgery for the Management of Staghorn Renal Calculi Open
Objective: To compare the stone clearance rate in patients treated with percutaneous nephrolithotomy (PCNL) versus open surgery for the management of staghorn renal calculi. Materials and Methods: In this comparative study, a total number …
View article: Fusion peptide constructs from antigens of M. tuberculosis producing high T-cell mediated immune response
Fusion peptide constructs from antigens of M. tuberculosis producing high T-cell mediated immune response Open
Non availability of effective anti-TB vaccine impedes TB control which remains a crucial global health issue. A fusion molecule based on immunogenic antigens specific to different growth phases of Mycobacterium tuberculosis can enhance T-c…
View article: Editorial: Antimicrobials alternatives for the prevention and treatment of veterinary infectious diseases
Editorial: Antimicrobials alternatives for the prevention and treatment of veterinary infectious diseases Open
EDITORIAL article Front. Vet. Sci., 09 September 2022Sec. Veterinary Infectious Diseases https://doi.org/10.3389/fvets.2022.1025150
View article: Implications for sequencing of biologic therapy and choice of second <scp>anti‐TNF</scp> in patients with inflammatory bowel disease: results from the <scp>IMmunogenicity</scp> to Second <scp>Anti‐TNF</scp> therapy (<scp>IMSAT</scp>) therapeutic drug monitoring study
Implications for sequencing of biologic therapy and choice of second <span>anti‐TNF</span> in patients with inflammatory bowel disease: results from the <span>IMmunogenicity</span> to Second <span>Anti‐TNF</span> therapy (<span>IMSAT</span>) therapeutic drug monitoring study Open
Summary Background Anti‐drug antibodies are associated with treatment failure to anti‐TNF agents in patients with inflammatory bowel disease (IBD). Aim To assess whether immunogenicity to a patient's first anti‐TNF agent would be associate…
View article: Using Blockchain to Ensure the Integrity of Digital Forensic Evidence in an IoT Environment
Using Blockchain to Ensure the Integrity of Digital Forensic Evidence in an IoT Environment Open
Digital forensics deals with digital evidence. Digital forensics is the study of data detection, acquisition, processing, analysis, and reporting. Encouraging the use of digital forensics in law enforcement investigations. With digital for…
View article: A STUDY OF ISSUES IN EDUCATIONAL MANAGEMENT AT HIGH SCHOOL LEVEL AT PUNJAB
A STUDY OF ISSUES IN EDUCATIONAL MANAGEMENT AT HIGH SCHOOL LEVEL AT PUNJAB Open
The school management is regarded as one of the most important managements in perspective of Pakistani schools. Educational management is a discipline with respect to the management of educational organizations was established to develop d…
View article: An Intelligent and Secured Privacy Preserving Framework For Wireless Body Area Networks (WBANs)
An Intelligent and Secured Privacy Preserving Framework For Wireless Body Area Networks (WBANs) Open
In recent years, developments in information technology and emerging technologies have greatly benefited e-health. The adoption of Wireless Body Area Networks is a perfect example (WBAN). The WBAN is a popular device. Medical care can be d…
View article: Additional file 9 of Secreted protein markers in oral squamous cell carcinoma (OSCC)
Additional file 9 of Secreted protein markers in oral squamous cell carcinoma (OSCC) Open
Additional file 9: Table S8.Public proteomics datasets; salivary proteome healthy vs. OSCC dataset by Chu et al. [8], human salivary proteome by Sivadasan et al. [9] and Normal Saliva Proteome database ( https://salivaryproteome.nidcr.nih.…
View article: Additional file 6 of Secreted protein markers in oral squamous cell carcinoma (OSCC)
Additional file 6 of Secreted protein markers in oral squamous cell carcinoma (OSCC) Open
Additional file 6: Table S5. 1724 secretome proteins were identified (˃5 average counts) in all HNSCC secretome.
View article: Additional file 11 of Secreted protein markers in oral squamous cell carcinoma (OSCC)
Additional file 11 of Secreted protein markers in oral squamous cell carcinoma (OSCC) Open
Additional file 11: Table S10. List of 205 differentially expressed up regulated proteins (P < 0.01) of OSCC tumor tissue vs. paired normal adjacent tissue predicted to be secreted, either via classical or non-classical secretion mechanism…
View article: Additional file 5 of Secreted protein markers in oral squamous cell carcinoma (OSCC)
Additional file 5 of Secreted protein markers in oral squamous cell carcinoma (OSCC) Open
Additional file 5: Table S4. List of 4472 identified proteins secretomes of HNSCC cell lines.
View article: Additional file 2 of Secreted protein markers in oral squamous cell carcinoma (OSCC)
Additional file 2 of Secreted protein markers in oral squamous cell carcinoma (OSCC) Open
Additional file 2: Table S1. List of 5123 identified proteins tumors compared to NAT of OSCC patients
View article: Additional file 8 of Secreted protein markers in oral squamous cell carcinoma (OSCC)
Additional file 8 of Secreted protein markers in oral squamous cell carcinoma (OSCC) Open
Additional file 8: Table S7. 132 overlapping OSCC tissue and HNSCC secretome candidates had a predicted signal peptide in their sequence.