Wakaba Fukushima
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View article: Real-world effectiveness of recombinant herpes Zoster vaccine: a retrospective, cohort study in Japan
Real-world effectiveness of recombinant herpes Zoster vaccine: a retrospective, cohort study in Japan Open
View article: Adverse reactions following first three doses of the BNT162b2 mRNA COVID-19 vaccine: A prospective cohort study on relationships with individual characteristics and previous experience of adverse reactions
Adverse reactions following first three doses of the BNT162b2 mRNA COVID-19 vaccine: A prospective cohort study on relationships with individual characteristics and previous experience of adverse reactions Open
A clear consensus on the factors contributing to adverse reactions following the mRNA COVID-19 vaccine has yet to be reached. Therefore, the present study investigated adverse reactions following the first three doses of the BNT162b2 mRNA …
View article: Real-world effectiveness of recombinant herpes zoster vaccine: A retrospective, cohort study in Japan
Real-world effectiveness of recombinant herpes zoster vaccine: A retrospective, cohort study in Japan Open
Background:In Japan, a two-dose, recombinant herpes zoster vaccine (RZV) has been available since 2020, but vaccination coverage is low because vaccination is voluntary. This study investigated the real-world effectiveness of the RZV for p…
View article: Articulating Materials Are Determinants of Survivorship of Hip Arthroplasties Performed for Nontraumatic Osteonecrosis of the Femoral Head
Articulating Materials Are Determinants of Survivorship of Hip Arthroplasties Performed for Nontraumatic Osteonecrosis of the Femoral Head Open
A nationwide multicenter follow-up cohort study of hip-replacement arthroplasties performed for nontraumatic osteonecrosis of the femoral head (ONFH) was conducted to clarify factors associated with need for reoperation. We analyzed 7393 a…
View article: Factors associated with dislocation after total hip arthroplasties performed for nontraumatic osteonecrosis of the femoral head: a multicenter cohort study of 5,983 hips
Factors associated with dislocation after total hip arthroplasties performed for nontraumatic osteonecrosis of the femoral head: a multicenter cohort study of 5,983 hips Open
Background and purpose: Nontraumatic osteonecrosis of the femoral head (ONFH) patients are at a higher dislocation risk after primary total hip arthroplasties (THAs) than osteoarthrosis patients. It has not been clear how large prosthetic …
View article: Durability of antibody titers and associated factors after the booster dose of <scp>COVID</scp>‐19 <scp>mRNA</scp> vaccination in <scp>Japanese SARS</scp>‐<scp>CoV</scp>‐2 infection‐naive residents in geriatric intermediate care facilities
Durability of antibody titers and associated factors after the booster dose of <span>COVID</span>‐19 <span>mRNA</span> vaccination in <span>Japanese SARS</span>‐<span>CoV</span>‐2 infection‐naive residents in geriatric intermediate care facilities Open
Aim Elderly adults are at higher risk for severe COVID‐19 infection. This multicenter, prospective cohort study assessed immunogenicity after COVID‐19 vaccinations in elderly residents compared with staff in geriatric intermediate care fac…
View article: Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination
Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination Open
Background: Current influenza A vaccines primarily induce neutralizing antibodies targeting the variable hemagglutinin (HA) head domain, limiting their effectiveness against diverse or emerging influenza A virus (IAV) subtypes. The conserv…
View article: Number of medical facilities within driving distance of residence and influenza vaccination status in Japan: A cross-sectional study
Number of medical facilities within driving distance of residence and influenza vaccination status in Japan: A cross-sectional study Open
Vaccine hesitancy primarily consists of confidence, complacency, and convenience, including geographical accessibility. However, few studies in developed countries have focused on the association between geographical accessibility to vacci…
View article: Sleep Problems and Quality of Life in Children with Epilepsy Without Neurodevelopmental Disorders
Sleep Problems and Quality of Life in Children with Epilepsy Without Neurodevelopmental Disorders Open
Background/Objectives: Sleep problems affect the quality of life (QoL) and treatment prognosis of children with epilepsy (CWE). We analyzed sleep problems and QoL in CWE but without neurodevelopmental disorders, which affect sleep and QoL.…
View article: Regional Disparities in Measles Vaccination Coverage and Their Associated Factors: An Ecological Study in Japan
Regional Disparities in Measles Vaccination Coverage and Their Associated Factors: An Ecological Study in Japan Open
This study showed regional disparities in measles vaccination coverage in Japan. Single-father households, age of mothers, and socioeconomic status may be key factors when municipalities consider strategies to improve vaccination coverage.
View article: Factors impacting antibody kinetics, including fever and vaccination intervals, in SARS-CoV-2-naïve adults receiving the first four mRNA COVID-19 vaccine doses
Factors impacting antibody kinetics, including fever and vaccination intervals, in SARS-CoV-2-naïve adults receiving the first four mRNA COVID-19 vaccine doses Open
To evaluate the antibody response following the initial four doses of mRNA vaccines (BNT162b2 or mRNA-1273) in SARS-CoV-2-naïve healthy adults and investigate factors influencing antibody titer increases, this prospective cohort study was …
View article: Strategies for pneumococcal vaccination in older adults in the coming era
Strategies for pneumococcal vaccination in older adults in the coming era Open
Pneumonia, predominantly caused by Streptococcus pneumoniae, remains a leading cause of global mortality. The 23-valent Pneumococcal polysaccharide vaccine (PPSV23) and conjugate vaccines (PCVs) are vital measures to fight against i…
View article: Time elapsed from definitive diagnosis to surgery for osteonecrosis of the femoral head: a nationwide observational study in Japan
Time elapsed from definitive diagnosis to surgery for osteonecrosis of the femoral head: a nationwide observational study in Japan Open
Objectives This study documents the time elapsed from the diagnosis of osteonecrosis of the femoral head (ONFH) to surgery, exploring the factors that influence ONFH severity. Design Retrospective observational study of a nationwide databa…
View article: Factors Related to Mortality in Patients with COVID-19 during the Early Phase of the Pandemic in Japan: An Observational Study Using the Osaka Prefectural Novel Coronavirus Response Status Management System
Factors Related to Mortality in Patients with COVID-19 during the Early Phase of the Pandemic in Japan: An Observational Study Using the Osaka Prefectural Novel Coronavirus Response Status Management System Open
Among those affected early in the COVID-19 epidemic, male sex, older age, first-surge infection, and underlying medical conditions were significantly associated with mortality. Our findings are expected to provide a useful reference for fu…
View article: Antibody responses after BNT162b2 vaccination in Japanese geriatric intermediate care facilities
Antibody responses after BNT162b2 vaccination in Japanese geriatric intermediate care facilities Open
Elderly people and steroid and NSAID users had lower antibody responses following the second vaccine dose.
View article: No association between inactivated influenza vaccination and influenza viral load at diagnosis among young Japanese children: An observational study of the 2013/2014 through 2017/2018 influenza seasons
No association between inactivated influenza vaccination and influenza viral load at diagnosis among young Japanese children: An observational study of the 2013/2014 through 2017/2018 influenza seasons Open
Background The association between inactivated influenza vaccination and viral load in young children remains unclear. Methods During the 2013/2014 to 2017/2018 influenza seasons in Japan, children under 6 years of age with pre‐defined inf…
View article: Pulmonary Tuberculosis Incidence among Interferon-Gamma Release Assay-Positive Individuals with Latent Tuberculosis Infection and Fibrotic Lesions in a Vulnerable Urban Population in Osaka City, Japan, 2015–2021
Pulmonary Tuberculosis Incidence among Interferon-Gamma Release Assay-Positive Individuals with Latent Tuberculosis Infection and Fibrotic Lesions in a Vulnerable Urban Population in Osaka City, Japan, 2015–2021 Open
Latent tuberculosis infection (LTBI) with fibrotic lesions (FL) can progress to active tuberculosis (TB). Most previous studies have used tuberculin skin tests, which have lower specificity than interferon-gamma release assays (IGRAs), for…
View article: Immunogenicity and safety of influenza vaccine in patients with lung cancer receiving immune checkpoint inhibitors: A single-center prospective cohort study
Immunogenicity and safety of influenza vaccine in patients with lung cancer receiving immune checkpoint inhibitors: A single-center prospective cohort study Open
Overall, influenza vaccination in patients with lung cancer receiving ICIs showed acceptable immunogenicity and safety, thus supporting annual influenza vaccination in this population.
View article: Incidence and risk factors for norovirus‐related diarrhea in Japanese geriatric intermediate care facilities: A prospective cohort study
Incidence and risk factors for norovirus‐related diarrhea in Japanese geriatric intermediate care facilities: A prospective cohort study Open
Aim The risk of developing infectious diarrhea among elderly residents at Japanese geriatric intermediate care facilities is unclear. We investigated the incidence rate and risk factors of norovirus‐related diarrhea at such facilities. Met…
View article: Antibody Responses after Bnt162b2 Vaccination in Japanese Geriatric Intermediate Care Facilities
Antibody Responses after Bnt162b2 Vaccination in Japanese Geriatric Intermediate Care Facilities Open
View article: Smoking and drinking habits relating to development of ulcerative colitis in Japanese: A multicenter case–control study
Smoking and drinking habits relating to development of ulcerative colitis in Japanese: A multicenter case–control study Open
Background and Aim The number of patients with ulcerative colitis (UC) has been increasing in Japan. To elucidate the risk factors for developing UC in Japan, a hospital‐based case–control study was conducted. This study examined the assoc…
View article: Survey of pediatricians concerning the human papillomavirus vaccine in Japan: Positive attitudes toward vaccination during the period of proactive recommendation being withheld
Survey of pediatricians concerning the human papillomavirus vaccine in Japan: Positive attitudes toward vaccination during the period of proactive recommendation being withheld Open
In 2013, the human papillomavirus (HPV) vaccine was introduced as a national immunization program in Japan. However, because of a wide range of symptoms after vaccination, the Japanese Ministry of Health, Labor and Welfare decided to withh…
View article: Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against community-acquired pneumonia in older individuals after the introduction of childhood 13-valent pneumococcal conjugate vaccine: A multicenter hospital-based case-control study in Japan
Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against community-acquired pneumonia in older individuals after the introduction of childhood 13-valent pneumococcal conjugate vaccine: A multicenter hospital-based case-control study in Japan Open
This study was unable to demonstrate the effectiveness of PPSV23 against all-cause and pneumococcal pneumonia after the introduction of childhood PCV13 in Japan. Nonetheless, additional studies are needed to validate these results.
View article: Kinetics of anti-SARS-CoV-2 antibody titer in healthy adults up to 6 months after BNT162b2 vaccination measured by two immunoassays: A prospective cohort study in Japan
Kinetics of anti-SARS-CoV-2 antibody titer in healthy adults up to 6 months after BNT162b2 vaccination measured by two immunoassays: A prospective cohort study in Japan Open
View article: Annual trends in adverse events following mumps vaccination in Japan: A retrospective study
Annual trends in adverse events following mumps vaccination in Japan: A retrospective study Open
The incidence of post-vaccination aseptic meningitis has declined significantly since 2001, and the incidence has remained stable at fewer than 3 cases per 100,000 doses since 2010. Multiple factors might have contributed to the decline in…
View article: Influence of Prior Influenza Vaccination on Current Influenza Vaccine Effectiveness in Children Aged 1 to 5 Years
Influence of Prior Influenza Vaccination on Current Influenza Vaccine Effectiveness in Children Aged 1 to 5 Years Open
Background: Although annual influenza vaccination is an important strategy used to prevent influenza-related morbidity and mortality, some studies have reported the negative influence of prior vaccination on vaccine effectiveness (VE) for …
View article: 655Association between Crohn's disease onset and oral hygiene: a Japanese multicenter case-control study
655Association between Crohn's disease onset and oral hygiene: a Japanese multicenter case-control study Open
Background The prevalence of Crohn’s disease is increasing in Japan, but risk factors for this disease have yet to be characterized. A recent study using mice, indicated that Klebsiella strains in the oral cavity may be associated with inf…
View article: 674The incidence and risk factors of acute infectious diarrhea at Japanese geriatric intermediate care facilities
674The incidence and risk factors of acute infectious diarrhea at Japanese geriatric intermediate care facilities Open
Background Norovirus infection and Clostridioides difficile infection (CDI) are major causes of acute infectious diarrhea at medical facilities. “Geriatric intermediate care facilities” are a type of medical facility that tend to the daily…
View article: 670Lifestyle risk factors for hepatocellular carcinoma in treated chronic hepatitis C patients
670Lifestyle risk factors for hepatocellular carcinoma in treated chronic hepatitis C patients Open
Background The purpose of this study was to identify lifestyle risk factors, such as cigarette smoking and alcohol consumption, associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis C patients who have a…
View article: 681Influenza vaccine effectiveness in young Japanese children over five seasons
681Influenza vaccine effectiveness in young Japanese children over five seasons Open
Background Evidence is limited for influenza vaccine effectiveness (VE) against laboratory-confirmed influenza among young children. Using test-negative design (a modified case-control study) which minimizes confounding by health care-seek…