Wakana Chikaishi
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View article: Cancer cachexia onset and survival outcomes in metastatic colorectal cancer: Comparative assessment of the asian working group for cachexia and the European palliative care research collaborative criteria, and utility of modified glasgow prognostic score
Cancer cachexia onset and survival outcomes in metastatic colorectal cancer: Comparative assessment of the asian working group for cachexia and the European palliative care research collaborative criteria, and utility of modified glasgow prognostic score Open
Objective Cachexia substantially affects the prognosis of patients with advanced cancer. While both the Asian Working Group for Cachexia (AWGC) and European Palliative Care Research Collaborative (EPCRC) criteria are widely used for diagno…
View article: Geriatric 8 score as a prognostic factor of the efficacy and safety of oxaliplatin-based chemotherapy in elderly patients with metastatic colorectal cancer
Geriatric 8 score as a prognostic factor of the efficacy and safety of oxaliplatin-based chemotherapy in elderly patients with metastatic colorectal cancer Open
View article: Neutrophil‑to‑lymphocyte ratio and risk of disease progression in patients with nivolumab‑treated unresectable or recurrent gastric cancer
Neutrophil‑to‑lymphocyte ratio and risk of disease progression in patients with nivolumab‑treated unresectable or recurrent gastric cancer Open
Studies have associated neutrophil-to-lymphocyte ratio (NLR) with overall survival (OS) and progression-free survival (PFS) in patients with gastric cancer (GC). The present study aimed to examine the relationship between dynamic changes i…
View article: Implication of <scp>IZUMO2</scp> in the cell‐in‐cell phenomenon: A potential therapeutic target for triple‐negative breast cancer
Implication of <span>IZUMO2</span> in the cell‐in‐cell phenomenon: A potential therapeutic target for triple‐negative breast cancer Open
Background Triple‐negative breast cancer (TNBC) is characterized by the loss of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The aggressive clinicopathological features and resistance to currently…
View article: Adiponectin‐expressing Treg‐containing T cell fraction inhibits tumor growth in orthotopically implanted triple‐negative breast cancer
Adiponectin‐expressing Treg‐containing T cell fraction inhibits tumor growth in orthotopically implanted triple‐negative breast cancer Open
Background In our previous study, we identified a population of adiponectin expressing regulatory T cells (Tregs) residing within thymic nurse cell complexes, which were capable of inhibiting the development of breast cancer in vitro. Trip…
View article: Potential activity of adiponectin‐expressing regulatory T cells against triple‐negative breast cancer cells through the cell‐in‐cell phenomenon
Potential activity of adiponectin‐expressing regulatory T cells against triple‐negative breast cancer cells through the cell‐in‐cell phenomenon Open
Background A population of regulatory T cells (Treg), which reside within thymic nurse cell complexes, express adiponectin and abrogate breast cancer development in transgenic mice. In this study, we examined whether adiponectin‐expressing…
View article: Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression
Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression Open
View article: Late recurrence of CD44 variant 9-positive gastric carcinoma 12 years after surgery: A case report
Late recurrence of CD44 variant 9-positive gastric carcinoma 12 years after surgery: A case report Open
Background Late recurrence of gastric cancer of over 10 years post-gastrectomy is extremely rare, and the mechanism of late recurrence is unclear. We report a case of para-aortic lymph node metastasis that recurred 12 years postoperatively…
View article: A Case of an Adenoid Cystic Carcinoma of the Breast
A Case of an Adenoid Cystic Carcinoma of the Breast Open
View article: A Case of Laparoscopic Surgery for Ulcerative Colitis in Pregnancy
A Case of Laparoscopic Surgery for Ulcerative Colitis in Pregnancy Open
症例は25歳の女性で，腹痛，下痢で近医を受診し，潰瘍性大腸炎と診断された．プレドニゾロン投与により炎症は寛解したが，4か月後に再燃した．同時期に妊娠が判明したため当院紹介となった．全大腸型・Matts grade 4であり，インフリキシマブ・顆粒球除去療法で効果が得られなかったため，手術適応と判断した．妊娠14週で母児の安全保持のため，3期分割手術を計画し，腹腔鏡下結腸亜全摘・回腸ストマ造設・S状結腸盲端腹壁固定を施行した．その後，妊娠41週・2,665 gで正常分娩を経て…
View article: An incarcerated internal hernia of the sigmoid colon through a defect in the broad ligament: A case report
An incarcerated internal hernia of the sigmoid colon through a defect in the broad ligament: A case report Open
View article: A Case of Colon Perforation during the Treatment with an Immune Checkpoint Inhibitor
A Case of Colon Perforation during the Treatment with an Immune Checkpoint Inhibitor Open
症例は88歳，男性．他院でStage IV A肺腺癌に対して免疫チェックポイント阻害剤のペムブロリズマブで加療していた．6コース投与後に血便・下痢をきたし，下部内視鏡検査で直腸S状部に潰瘍を認め，大腸炎と診断された．プレドニゾロン投与で軽快したが，治療開始31日後に強い腹痛が出現しCT検査で腹腔内遊離ガスを認め，消化管穿孔の疑いで当院へ救急搬送された．緊急下部内視鏡検査で直腸S状部に深い潰瘍を認め，同部位の穿孔を疑い緊急手術を行った．直腸S状部の穿孔部位はピンホール状であり…