Explanipedia

Molecular modeling and implications of Biochanin A on ghrelin and IGF-1/myostatin signaling in radiation triggered cachexia Open

Aya Shaheen, Heba A. Gheita, Heba M. Karam, Nashwa H. Zaher, Walaa A. El‐Sabbagh · 2024

Background Cachexia, a loss of appetite and body weight as a result of systemic inflammation, considered one of the unavoidable side effects of radiation therapy. Controlling ghrelin (Ghr) levels could assist in alleviating this condition …

Gastroprotective and microbiome-modulating effects of ubiquinol in rats with radiation-induced enteropathy Open

Walaa A. Eraqi, Walaa A. El‐Sabbagh, Ramy K. Aziz, Mostafa S. Elshahed, Noha H. Youssef , et al. · 2024

Ubiquinol attenuates γ-radiation induced coronary and aortic changes via PDGF/p38 MAPK/ICAM-1 related pathway Open

Walaa A. El‐Sabbagh, Noha A. Fadel, Rania M. El‐Hazek, Ahmed H. Osman, Laila Ramadan · 2023

Endothelial vascular injury is one of the most pivotal disorders emerging during radiotherapy. It is crucial to rely on strong antioxidants to defend against vascular damage. The current study was carried out to investigate the ameliorativ…

Novel VEGFR2 inhibitors with thiazoloquinoxaline scaffold targeting hepatocellular carcinoma with lower cardiotoxic impact Open

Reham M. M. El‐Hazek, Nashwa H. Zaher, Mostafa G. M. El-Gazzar, Noha A. Fadel, Walaa A. El‐Sabbagh · 2023

Hepatocellular carcinoma (HCC) is a fatal tumor which is usually diagnosed at advanced stage. Molecular targeted drugs were used recently to treat HCC, however, due to serious side effects, mainly cardiotoxicity and emergence of resistance…

Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach Open

Nashwa H. Zaher, Reham M. M. El‐Hazek, Mostafa G. M. El-Gazzar, Walaa A. El‐Sabbagh, Noha A. Fadel · 2023

Renal cell carcinoma (RCC) is the most fatal tumor in the urinary system. Resistance development and unmet effective responses, request new anticancer agents with better therapeutic index. Ten new imino-thiazolo-quinoxaline derivatives (5a…

Antioxidant activity of Malpighia glabra L., leaves extract Open

Amany M. Fekry, Walaa A. El‐Sabbagh, Marwa S. Abu Bakr, Mona A. El‐Ghazaly, Abd El-Salam Mohamed · 2021

Malpighia glabra.L (Acerola) fruits have wide global medicinal uses due to rich antioxidant contents.Little studies were carried on other parts of plant.Malpighia glabra.L leaves (1.5 kg) was subjected to soxhlet exhaustive extraction with…

Micellar solubilization enhances the anti-inflammatory effect of xanthohumol Open

Mohamed T. Khayyal, Rania M. El‐Hazek, Walaa A. El‐Sabbagh, Jan Frank, Dariush Behnam , et al. · 2020

The findings confirm that micellar solubilization of xanthohumol enhances its anti-inflammatory activity, probably as a result of improving its bioavailabilty. The solubilized xanthohumol may prove to be a promising adjuvant tool for anti-…

Effect of Clodronate Alone or In Combination with Vitamin E on Demineralization Induced By Whole Body Gamma Irradiation in Rats Open

Heba A. Gheita, Walaa A. El‐Sabbagh, Rania M. Abdelsalam, Amina S. Attia, Mona A. El‐Ghazaly · 2020

B ISPHOSPHONATES usually have been chosen in cancer treatment protocols for the management of fractures risk and controlling metastatic bone pain following chemo-and radiotherapy.This study aims at investigating the beneficial effect of cl…

Incorporation of curcumin into micelles markedly enhances its anti-inflammatory activity, particularly in combination with other extracts Open

Mohamed T. Khayyal, Mona Abdel‐Tawab, Dariush Behnam, Walaa A. El‐Sabbagh, Rania M. El‐Hazek · 2018

Native extracts of Curcumin are known to exert anti-inflammatory properties, but have poor bioavailability when given orally. Through advanced micellation technology, it has been possible to produce stable solubilisates of these extracts, …

Beneficial Effects of Piperine in global cerebral ischemia/reperfusion model in irradiated rats Open

Samar S. Azab, Walaa A. El‐Sabbagh, Mohammed Abd El-Daim, Engy Refaat Rashed · 2017

S troke is the third cause of death and a leading cause of chronic disability all around the world.Inflammation and oxidative stress are common pathogenic pathways of brain injury induced by ischemia/reperfusion (I/R).This work aims to inv…

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