Walid K. Chatila
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View article: Supplementary Video 2 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Video 2 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
3D rendering of melanoma/switched keratinocyte contacts and stained vesicles in human melanoma/keratinocyte co-cultures
View article: Supplementary Video 4 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Video 4 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
Representative trace videos of spike activity in melanoma/keratinocyte co-cultures +/- GABA signaling
View article: Supplementary Video 1 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Video 1 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
3D rendering of melanoma/keratinocyte contacts in zebrafish embryos
View article: Supplementary Table 2 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Table 2 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
RNA-seq and GSEA results in switched vs non-switched keratinocytes
View article: Supplementary Table 1 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Table 1 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
LOPAC Screen results in melanoma keratinocyte co-cultures
View article: Supplementary Figures S1-S17 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Figures S1-S17 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
Combined supplementary figures and figure legends. Supplementary Fig. 1: Switching requires direct contact between nascent melanoma cells and keratinocytes in vivo. Supplementary Fig. 2: Switching requires direct contact between melanoma c…
View article: Supplementary Video 3 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Supplementary Video 3 from GABA Regulates Electrical Activity and Tumor Initiation in Melanoma Open
3D rendering of gephyrin positive clusters in melanoma/keratinocyte co-cultures
View article: Ultrasensitive ctDNA monitoring for organ preservation in patients with locally advanced rectal cancer
Ultrasensitive ctDNA monitoring for organ preservation in patients with locally advanced rectal cancer Open
Optimal selection of patients with locally advanced rectal cancer for watch and wait (WW) and optimal management during follow-up remain challenging. We employed a primary-tumor-informed whole genome sequencing (WGS) assay to detect circul…
View article: Genomic and clinical parallels between US and Japanese gastric cancers: a propensity score-matched cohort study
Genomic and clinical parallels between US and Japanese gastric cancers: a propensity score-matched cohort study Open
Introduction Gastric cancer incidence, risk factors, and survival outcomes differ significantly between Japan and the United States. These disparities have led to the belief that gastric cancer represents biologically distinct diseases acr…
View article: Supplementary Table S3 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Supplementary Table S3 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma Open
Clinicopathologic Features of the Appendix-Specific Survival Analysis Cohort
View article: Supplementary Table S1 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Supplementary Table S1 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma Open
Genes evaluated by the MSK IMPACT germline sequencing panel
View article: Supplementary Figure S7 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Figure S7 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Baseline biopsies from a patient demonstrating significant intra-patient heterogeneity with diffusely HER2+ and PD-L1– primary tumor and HER2– but PD-L1 CPS 100 retroperitoneal lymph node with neuroendocrine differentiation.
View article: Supplementary Figure S1 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Supplementary Figure S1 from The Impact of Germline Alterations in Appendiceal Adenocarcinoma Open
Supplemental Figure 1: Appendix cancer specific survival in patients with stage IV appendiceal adenocarcinoma stratified by presence of a germline variant. Highlighted Kaplan Meier curve areas display the 95% confidence interval for the re…
View article: Supplementary Methods S1 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Methods S1 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Supplemental Methods
View article: Supplementary Figure S3 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Figure S3 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Response to pembrolizumab and trastuzumab induction according to pre-treatment 89Zr-trastuzumab PET avidity.
View article: Supplementary Data S1 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Data S1 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Supplemental Data, Spreadsheet
View article: Supplementary Figure S10 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Figure S10 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Identifying intratumor clonal selection and associated resistance mechanisms. a, Inferred tumor clones paired pre-treatment and post-cycle 2 CAPOX + trastuzumab scRNA-seq demonstrates rapid clearance of highly ERBB2 expression (red) clones…
View article: Supplementary Table S5 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S5 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Genes with Oncogenic Alterations Identified by MSK-IMPACT with Frequency > 5%.
View article: Supplementary Figure S2 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Figure S2 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Survival and response in patients receiving trastuzumab/chemotherapy + PD-1 inhibition on- or off-protocol (n=66). a, Progression-free survival and objective response rate by cohort. b, Overall survival by cohort.
View article: Supplementary Table S3 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S3 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Correlation of 89Zr PET Uptake and HER2 Status
View article: Supplementary Table S2 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S2 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Representativeness of Study Participants.
View article: Supplementary Figure S8 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Figure S8 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
PIK3CD S367L demonstrate increased phosphorylation of AKT. Upon progression, 1 patient developed a PIK3CD S367L mutation (location indicated in gene map), a variant of undetermined significance in the carboxy terminal C2 domain. Above, wes…
View article: Supplementary Table S6 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S6 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Metastatic Sites Involved Prior to HER2-Directed Therapy.
View article: Supplementary Table S7 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S7 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Univariable Cox Proportional Hazard for PFS in HER2-targeted retrospective cohort.
View article: Supplementary Table S8 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S8 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Multivariable Cox Proportional Hazard for PFS in HER2-targeted retrospective cohort (n=217).
View article: Supplementary Figure S5 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Figure S5 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Lesions without pre-treatment ERBB2 amplification appear less likely to respond to pembrolizumab and trastuzumab induction. Lesion-level CT response after 1 dose of pembrolizumab and trastuzumab among patients with baseline tumor-matched c…
View article: Supplementary Table S1 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Supplementary Table S1 from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer Open
Pembrolizumab/Trastuzumab/Chemotherapy Protocol Patient Demographics
View article: Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers
Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers Open
View article: Prospective characterization of germline variants in patients with gliomas and glioneuronal tumors
Prospective characterization of germline variants in patients with gliomas and glioneuronal tumors Open
Several tumor predisposition syndromes have been linked to the development of gliomas and glioneuronal tumors (glioma/GNT). For many pathogenic germline variants, the prevalence and clinical significance remain unclear. Germline variants a…
View article: Supplementary Data Figure S3 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma
Supplementary Data Figure S3 from RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma Open
Effect of MAPK and RAS exchange inhibition in RIT1-driven models