Walid Idi
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View article: Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis
Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis Open
Lipid droplets (LDs), once considered inert lipid stores, are now recognized as active regulators of lipid metabolism, stress responses, and protein quality control in the brain. Their dysregulation is increasingly linked to neurodegenerat…
View article: Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease
Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease Open
Studying Parkinson's disease (PD) is complex due to a lack of cellular models mimicking key aspects of protein pathology. Here, we present a protocol for inducing and monitoring α-synuclein aggregation in living cells using optogenetics. W…
View article: Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons
Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons Open
Generation of functional human dopaminergic (DA) neurons from human induced pluripotent stem cells (hiPSCs) is a crucial tool for modeling dopamine-related human diseases and cell replacement therapies. Here, we present a protocol to combi…
View article: Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain Open
Descending control from the brain to the spinal cord shapes our pain experience, ranging from powerful analgesia to extreme sensitivity. Increasing evidence from both preclinical and clinical studies points to an imbalance toward descendin…
View article: A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease Open
Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system. However, the exact role of protein aggregation in the pathophysiology of these d…
View article: Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association Open
Abnormal accumulation of the protein α- synuclein (α-syn) into proteinaceous inclusions called Lewy bodies (LB) is the neuropathological hallmark of Parkinson’s disease (PD) and related disorders. Interestingly, a growing body of evidence …