Wallis Rudnick
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View article: Impact of the COVID-19 pandemic on hospital antimicrobial purchasing in Canada (2018–2021): An exploratory analysis
Impact of the COVID-19 pandemic on hospital antimicrobial purchasing in Canada (2018–2021): An exploratory analysis Open
Background: The impact of the COVID-19 pandemic on antimicrobial use in Canadian hospitals is not well characterized. We explored the relationship between the COVID-19 pandemic and Canadian hospital antimicrobial purchasing (AMP)—a proxy f…
View article: Trends in Severe Outcomes Among Adult and Pediatric Patients Hospitalized With COVID-19 in the Canadian Nosocomial Infection Surveillance Program, March 2020 to May 2022
Trends in Severe Outcomes Among Adult and Pediatric Patients Hospitalized With COVID-19 in the Canadian Nosocomial Infection Surveillance Program, March 2020 to May 2022 Open
Importance Trends in COVID-19 severe outcomes have significant implications for the health care system and are key to informing public health measures. However, data summarizing trends in severe outcomes among patients hospitalized with CO…
View article: Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018
Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018 Open
View article: Overview of Canada's Antimicrobial Resistance Network (AMRNet): A data-driven One Health approach to antimicrobial resistance surveillance
Overview of Canada's Antimicrobial Resistance Network (AMRNet): A data-driven One Health approach to antimicrobial resistance surveillance Open
The Antimicrobial Resistance Network (AMRNet) is a laboratory-based antimicrobial resistance (AMR) surveillance system under development at the Public Health Agency of Canada's (PHAC's) National Microbiology Laboratory. The AMRNet surveill…
View article: Aperçu du Réseau de la résistance aux antimicrobiens (RésRAM) du Canada : une approche Une seule santé axée sur les données pour la surveillance de la résistance aux antimicrobiens
Aperçu du Réseau de la résistance aux antimicrobiens (RésRAM) du Canada : une approche Une seule santé axée sur les données pour la surveillance de la résistance aux antimicrobiens Open
antimicrobiens (RésRAM) du Canada : une approche Une seule santé axée sur les données pour la surveillance de la résistance aux antimicrobiens.
View article: Trends in <i>Clostridioides difficile</i> infection rates in Canadian hospitals during the coronavirus disease 2019 (COVID-19) pandemic
Trends in <i>Clostridioides difficile</i> infection rates in Canadian hospitals during the coronavirus disease 2019 (COVID-19) pandemic Open
The coronavirus disease 2019 (COVID-19) pandemic has placed significant burden on healthcare systems. We compared Clostridioides difficile infection (CDI) epidemiology before and during the pandemic across 71 hospitals participating in the…
View article: Antimicrobial use in Canadian acute-care hospitals: Findings from three national point-prevalence surveys between 2002 and 2017
Antimicrobial use in Canadian acute-care hospitals: Findings from three national point-prevalence surveys between 2002 and 2017 Open
Objectives: The Canadian Nosocomial Infection Surveillance Program conducted point-prevalence surveys in acute-care hospitals in 2002, 2009, and 2017 to identify trends in antimicrobial use. Methods: Eligible inpatients were identified fro…
View article: Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada
Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada Open
Between 18 Dec 2017 and 27 June 2018, a mumps outbreak occurred in two Canadian Indigenous communities. An outbreak dose of mumps-containing vaccine was offered as part of control measures. We conducted a cohort study and survival analysis…
View article: Patients in hospital with laboratory-confirmed COVID-19 in a network of Canadian acute care hospitals, Mar. 1 to Aug. 31, 2020: a descriptive analysis
Patients in hospital with laboratory-confirmed COVID-19 in a network of Canadian acute care hospitals, Mar. 1 to Aug. 31, 2020: a descriptive analysis Open
Surveillance findings indicate that a high proportion of Canadian patients in hospital with COVID-19 during the first 6 months of the pandemic were older adults with underlying medical conditions. Active surveillance of patients in hospita…
View article: Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada
Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada Open
Between 18-Dec-2017 and 27-Jun-2018, a mumps outbreak occurred in two Canadian Indigenous communities. An outbreak dose of mumps-containing vaccine was offered as part of control measures. We conducted a cohort study and survival analysis …
View article: Variability in Antimicrobial Use Among Hospitals Participating in the Canadian Nosocomial Infection Surveillance Program
Variability in Antimicrobial Use Among Hospitals Participating in the Canadian Nosocomial Infection Surveillance Program Open
Background: The association between antimicrobial use (AMU) and emergence of antimicrobial resistance is well documented. The Canadian Nosocomial Infection Surveillance Program (CNISP) has conducted sentinel surveillance of AMU at particip…
View article: Central-line–Associated Bloodstream Infections Among Adult Intensive Care Unit Patients in Canadian Hospitals, 2011–2018
Central-line–Associated Bloodstream Infections Among Adult Intensive Care Unit Patients in Canadian Hospitals, 2011–2018 Open
Background: Nosocomial central-line–associated bloodstream infections (CLABSIs) are an important cause of morbidity and mortality in hospitalized patients. CLABSI surveillance establishes rates for internal and external comparison, identif…
View article: Prevalence of Candida auris in Canadian acute care hospitals among at-risk patients, 2018
Prevalence of Candida auris in Canadian acute care hospitals among at-risk patients, 2018 Open
To identify the prevalence of C. auris in Canadian patients who are potentially at risk for colonization, we screened 488 patients who were either hospitalized abroad, had a carbapenemase-producing organism (CPO), or were in units with hig…
View article: Antimicrobial use among adult inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program: 2009 to 2016
Antimicrobial use among adult inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program: 2009 to 2016 Open
View article: 2716. Persistence of 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Serotypes in Invasive Pneumococcal Disease in Adults in Southern Ontario Canada Despite Routine Pediatric Vaccination
2716. Persistence of 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Serotypes in Invasive Pneumococcal Disease in Adults in Southern Ontario Canada Despite Routine Pediatric Vaccination Open
Background In Ontario, Canada, PCV13 is covered for immunocompromised (IC) adults over 50y. PCV13 programs are thought not to be cost-effective in other adults because it is assumed that herd immunity from pediatric vaccination programs (P…
View article: 462. Prospective Surveillance of Invasive Group A Streptococcal Infections in Toronto, Ontario, Canada: 1992–2017
462. Prospective Surveillance of Invasive Group A Streptococcal Infections in Toronto, Ontario, Canada: 1992–2017 Open
Background. Background Invasive Group A streptococcal (iGAS) infections remain a substantial source of morbidity and mortality. We explore the clinical and molecular epidemiology of iGAS infections in Toronto, Ontario, Canada over a 26-yea…
View article: Trends in health care–associated infections in acute care hospitals in Canada: an analysis of repeated point-prevalence surveys
Trends in health care–associated infections in acute care hospitals in Canada: an analysis of repeated point-prevalence surveys Open
In CNISP hospitals, there was a decline in the prevalence of health care-associated infection in 2017 compared with previous surveys. However, strategies to prevent infections associated with medical devices should be developed. Apart from…
View article: 1426. Impact of Routine Pediatric PCV13 on the Incidence and Severity of Invasive Pneumococcal Disease in Adults in Ontario, Canada
1426. Impact of Routine Pediatric PCV13 on the Incidence and Severity of Invasive Pneumococcal Disease in Adults in Ontario, Canada Open
BACKGROUND: Monitoring the incidence and severity of disease due to varied pneumococcal (Pn) serotypes (STs) over time is important in assessing the benefit of Pn vaccines. We describe changes in adult IPD after the 2010 introduction of ro…
View article: 2401. Risk Factors for Antimicrobial Resistance in Invasive Pneumococcal disease (IPD) in Toronto, Canada, 2012–2017
2401. Risk Factors for Antimicrobial Resistance in Invasive Pneumococcal disease (IPD) in Toronto, Canada, 2012–2017 Open
BACKGROUND: Several studies have documented factors predictive of antimicrobial resistance (AMR) in invasive pneumococcal disease(IPD). However, the implementation of routine pediatric PCV programs, antimicrobial stewardship, and increasin…
View article: Factors Associated With 30-Day Mortality Rate in Respiratory Infections Caused by Streptococcus pneumoniae
Factors Associated With 30-Day Mortality Rate in Respiratory Infections Caused by Streptococcus pneumoniae Open
In multivariable analysis of associations between initial antibiotic therapy and clinical outcomes in 5005 patients with microbiologically confirmed Streptococcus pneumoniae infections, "discordant" empiric antibiotic therapy was not assoc…
View article: Changing Epidemiology of Invasive Pneumococcal Disease due to Conjugate Vaccine Serotypes in Toronto, Canada After Introduction of a Routine Pediatric PCV13 Program
Changing Epidemiology of Invasive Pneumococcal Disease due to Conjugate Vaccine Serotypes in Toronto, Canada After Introduction of a Routine Pediatric PCV13 Program Open
In Ontario a publicly funded PCV7 infant program (3 + 1 schedule), was introduced in 1/2005, PCV10 in 10/2009 and PCV13 in 11/2010 (2 + 1 schedule with catch-up to 35m). TIBDN performs population-based surveillance for invasive pneumococca…
View article: Invasive Pneumococcal Disease (IPD) in Children and Adults Following Introduction of Pneumococcal Conjugate Vaccines: Data From Population Based Surveillance 2001–2015
Invasive Pneumococcal Disease (IPD) in Children and Adults Following Introduction of Pneumococcal Conjugate Vaccines: Data From Population Based Surveillance 2001–2015 Open
Background.In Ontario, PCV7 was publicly funded in Januar 2005 (3 + 1 schedule), PCV10 in October 2009 and PCV13 in November 2010 (2 + 1 schedule with catchup for up to 35 months old).TIBDN performs population-based surveillance for invasi…
View article: Seroepidemiology of Invasive Pneumococcal Disease in Patients With Chronic Obstuctive Pulmonary Disease (COPD), Toronto, Canada
Seroepidemiology of Invasive Pneumococcal Disease in Patients With Chronic Obstuctive Pulmonary Disease (COPD), Toronto, Canada Open
View article: Invasive Pneumococcal Disease Among Immunocompromised Persons: Implications for Vaccination Programs
Invasive Pneumococcal Disease Among Immunocompromised Persons: Implications for Vaccination Programs Open
Immunocompromised individuals comprised 28% of IPD. Both PPV23 and herd immunity from pediatric PCV7 were associated with reductions in IPD in immunocompromised populations. PCV13 vaccination of immunocompromised adults may substantially r…
View article: Risk of Infection Among Patients Colonized With MRSA in an Acute Care Hospital, 2000–2012
Risk of Infection Among Patients Colonized With MRSA in an Acute Care Hospital, 2000–2012 Open
View article: Incidence of Invasive Pneumococcal Disease (IPD) Post Pneumococcal Conjugate Vaccines in Toronto/Peel, Canada, 2001–2015
Incidence of Invasive Pneumococcal Disease (IPD) Post Pneumococcal Conjugate Vaccines in Toronto/Peel, Canada, 2001–2015 Open
View article: Invasive Group A Streptococcal Infections in Ontario, Canada: 1992–2013
Invasive Group A Streptococcal Infections in Ontario, Canada: 1992–2013 Open
View article: Corticosteroid Therapy in Critical Illness due to Seasonal and Pandemic Influenza
Corticosteroid Therapy in Critical Illness due to Seasonal and Pandemic Influenza Open
BACKGROUND: Survey data suggest that Canadian intensivists administer corticosteroids to critically ill patients primarily in response to airway obstruction, perceived risk for adrenal insufficiency and hemodynamic instability. OBJECTIVE: …