Walther Klerx
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View article: The Effects of Filter Ventilation and Expanded Tobacco on the Tar, Nicotine and Carbon Monoxide Yields from Cigarettes Sold in Australia
The Effects of Filter Ventilation and Expanded Tobacco on the Tar, Nicotine and Carbon Monoxide Yields from Cigarettes Sold in Australia Open
Cigarette brand variant names and characteristics such as the taste and feel of the smoke can mislead consumers into believing some products are less harmful. We assessed the characteristics of three common cigarette variants sold in Austr…
View article: On the extension of the use of a standard operating procedure for nicotine, glycerol and propylene glycol analysis in e-liquids using mass spectrometry
On the extension of the use of a standard operating procedure for nicotine, glycerol and propylene glycol analysis in e-liquids using mass spectrometry Open
This study indicates that it is possible to apply the available EU-JATC SOP and the WHO TobLabNet SOP11 even in laboratories that do not have access to an FID, for example, to analyze flavors, trace compounds or carcinogenic, mutagenic, or…
View article: Determination of Nicotine Protonation State in E-Liquids by Low-Resolution Benchtop NMR Spectroscopy
Determination of Nicotine Protonation State in E-Liquids by Low-Resolution Benchtop NMR Spectroscopy Open
Over several years, e-liquids with "nicotine salts" have gained considerable popularity. These e-liquids have a low pH, at which nicotine occurs mostly in its monoprotonated form. Manufacturers usually accomplish this by the addition of an…
View article: Impact of More Intense Smoking Parameters and Flavor Variety on Toxicant Levels in Emissions of a Heated Tobacco Product
Impact of More Intense Smoking Parameters and Flavor Variety on Toxicant Levels in Emissions of a Heated Tobacco Product Open
Introduction IQOS HEETS are promoted as reduced-risk alternatives to cigarettes. Although some studies have investigated the chemical composition of HEETS emissions, little is known on whether toxicant levels in such emissions are affected…
View article: Physiologically‐Based Kinetic Modeling of Intravenously Administered Gold (Au) Nanoparticles
Physiologically‐Based Kinetic Modeling of Intravenously Administered Gold (Au) Nanoparticles Open
Physiologically‐based kinetic (PBK) modeling is a valuable tool to understand the kinetics of nanoparticles (NPs) in vivo. However, estimating PBK parameters remains challenging and commonly requires animal studies. To develop predictive m…
View article: Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function
Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function Open
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of tobacco, reactive aldehydes such as acetaldehyde, acrolein, and formald…
View article: Flavor accessories: Increasing tobaccoproducts’ attractiveness drop-by-drop
Flavor accessories: Increasing tobaccoproducts’ attractiveness drop-by-drop Open
reports of data from original research.• Policy Case Studies -brief articles on policy development at a regional or national level.• Study Protocols -Articles describing a research protocol of a study.• Methodology Papers -Papers that pres…
View article: Variations in cigarette brand characteristics: can consumers tell the difference?
Variations in cigarette brand characteristics: can consumers tell the difference? Open
Objectives Sensory experience is an important determinant of smoking initiation, brand choice and harm perception, but little is known about how cigarette design shapes sensory experience. This study reports which variations in tobacco ble…
View article: Improving the Analysis of E-Cigarette Emissions: Detecting Human “Dry Puff” Conditions in a Laboratory as Validated by a Panel of Experienced Vapers
Improving the Analysis of E-Cigarette Emissions: Detecting Human “Dry Puff” Conditions in a Laboratory as Validated by a Panel of Experienced Vapers Open
Introduction: E-cigarette product regulation requires accurate analyses of emissions. User behavior, including device power setting selection, should be mimicked closely when generating e-cigarette emissions in a laboratory. Excessively hi…
View article: Aldehyde and Volatile Organic Compound Yields in Commercial Cigarette Mainstream Smoke Are Mutually Related and Depend on the Sugar and Humectant Content in Tobacco
Aldehyde and Volatile Organic Compound Yields in Commercial Cigarette Mainstream Smoke Are Mutually Related and Depend on the Sugar and Humectant Content in Tobacco Open
Introduction The World Health Organization (WHO) Framework Convention on Tobacco control recognizes the need for tobacco product regulation. In line with that, the WHO Study Group on Tobacco Product Regulation (TobReg) proposed to regulate…
View article: The Health Risks of Electronic Cigarette Use to Bystanders
The Health Risks of Electronic Cigarette Use to Bystanders Open
This works aimed to assess the health risks of e-cigarette use to bystanders. The exhaled breath of 17 volunteers was collected while they were vaping, and the levels of nicotine, propylene glycol, glycerol, formaldehyde, acetaldehyde, acr…
View article: Cigarette Filter Ventilation and Smoking Protocol Influence Aldehyde Smoke Yields
Cigarette Filter Ventilation and Smoking Protocol Influence Aldehyde Smoke Yields Open
The WHO study group on tobacco product regulation (TobReg) advised regulating and lowering toxicant levels in cigarette smoke. Aldehydes are one of the chemical classes on the TobReg smoke toxicants priority list. To provide insight in fac…
View article: The health risks of using e-cigarettes
The health risks of using e-cigarettes Open
Engelse vertaling van rapport 2014-0143: De gezondheidsrisico's van het gebruik van e-cigaretten
View article: Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol
Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol Open
Already after one puff of the shisha-pen, the concentrations of propylene glycol and glycerol are sufficiently high to potentially cause irritation of the airways. New products such as the shisha-pen should be detected and risks should be …