Gang Wang
YOU?
Author Swipe
View article: YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination
YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination Open
Bladder cancer (BLCA) remains a highly lethal genitourinary malignancy with complex tumor biology and limited therapeutic strategies. This study investigates the oncogenic role of YKT6, a SNARE protein, in BLCA progression and molecular me…
View article: Machine learning-based prediction model for omental metastasis in right-sided colon cancer patients: a retrospective multicenter study
Machine learning-based prediction model for omental metastasis in right-sided colon cancer patients: a retrospective multicenter study Open
Our study developed and validated an XGB-based machine learning model that could accurately predict OM in RCC patients using routine preoperative variables. This model demonstrates strong discriminative ability and clinical utility, assist…
View article: Modeling macroscopic brain dynamics with brain-inspired computing architecture
Modeling macroscopic brain dynamics with brain-inspired computing architecture Open
Understanding the brain requires modeling large-scale neural dynamics, where coarse-grained modeling of macroscopic brain behaviors is a powerful paradigm for linking brain structure to function with empirical data. However, the model inve…
View article: Curcumol Targets the VHL/HIF-1α Axis to Suppress Glycolysis-Driven Progression in Colorectal Cancer
Curcumol Targets the VHL/HIF-1α Axis to Suppress Glycolysis-Driven Progression in Colorectal Cancer Open
Background: Hypoxia-induced glycolysis represents a hallmark of colorectal cancer (CRC) progression and contributes significantly to therapeutic resistance. Curcumol, a natural sesquiterpenoid derived from Curcumae Rhizoma, has demonstrate…
View article: The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma
The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma Open
Background: Valproic acid (VPA), a branched short-chain fatty acid, is extensively utilized as both an antiepileptic medication and a mood stabilizer. However, the complete pharmacological functions of VPA on programmed cell death are stil…
View article: Comparing Clinical Efficacy and Quality of Life Between Transesophageal Echocardiography-Guided and X-Ray Guided Percutaneous Occlusion in Adults With Secundum Atrial Septal Defect
Comparing Clinical Efficacy and Quality of Life Between Transesophageal Echocardiography-Guided and X-Ray Guided Percutaneous Occlusion in Adults With Secundum Atrial Septal Defect Open
AIM: This study aims to compare the clinical efficacy and quality of life between transesophageal echocardiography (TEE)-guided and X-ray-guided percutaneous closure in adults with secundum atrial septal defect (ASD). METHODS: A retrospect…
View article: Hepatic inflammatory myofibroblastic tumor: A case report and literature review
Hepatic inflammatory myofibroblastic tumor: A case report and literature review Open
Rationale: Hepatic inflammatory myofibroblastic tumor (HIMT) is a rare intermediate neoplasm, characterized by localized proliferation and low metastatic potential. Despite its benign nature, HIMT exhibits malignant features including recu…
View article: Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease
Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease Open
This study aimed to investigate the combined impact of zinc (Zn) intake and anemia on the atherosclerotic cardiovascular disease (ASCVD) risk score of patients with chronic kidney disease (CKD). A total of 2,612 individuals diagnosed with …
View article: Meta-analysis of the effects of multimodal physical therapy on improving depression
Meta-analysis of the effects of multimodal physical therapy on improving depression Open
BACKGROUND Depression is a widespread psychological disorder that has substantial effects on public health and society. Conventional therapies include medication and psychotherapy, recent investigations have highlighted the possible advant…
View article: RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer
RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer Open
The E3 ubiquitin ligase RNF112 is significantly downregulated in bladder cancer (BLCA) and is correlated with disease progression. In vitro and in vivo studies indicated that RNF112 suppresses BLCA cell proliferation, migration, and lipid …
View article: Integrating single-cell RNA sequencing, WGCNA, and machine learning to identify key biomarkers in hepatocellular carcinoma
Integrating single-cell RNA sequencing, WGCNA, and machine learning to identify key biomarkers in hepatocellular carcinoma Open
The microarray and single-cell RNA-sequencing (scRNA-seq) datasets of hepatocellular carcinoma (HCC) were downloaded from the Gene Expression Omnibus (GEO) database. Differential expression analysis and weighted gene co-expression network …
View article: [Corrigendum] RNA interference-mediated depletion of TRPM8 enhances the efficacy of epirubicin chemotherapy in prostate cancer LNCaP and PC3 cells
[Corrigendum] RNA interference-mediated depletion of TRPM8 enhances the efficacy of epirubicin chemotherapy in prostate cancer LNCaP and PC3 cells Open
[This corrects the article DOI: 10.3892/ol.2018.7847.].
View article: RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10
RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10 Open
RNA-binding proteins (RBPs) are pivotal mediators of the alternative splicing (AS) machinery of pre-mRNA. Research has demonstrated that the AS process is significantly dysregulated and plays a crucial role in bladder cancer (BLCA). We con…
View article: Association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia: a meta-analysis
Association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia: a meta-analysis Open
Our meta-analysis suggests that the ABCB1 C3435 T mutation may enhance the MTX-induced hepatotoxicity in childhood acute lymphoblastic leukemia.
View article: Scoparone suppresses proliferation and cell cycle of hepatocellular carcinoma cells via inhibiting AKT/GSK-3β/cyclin D1 signaling pathway
Scoparone suppresses proliferation and cell cycle of hepatocellular carcinoma cells via inhibiting AKT/GSK-3β/cyclin D1 signaling pathway Open
Scoparone inhibited HCC cell viability by targeting the AKT/GSK-3β/cyclin D1 pathway.
View article: Inflection points in hearing deterioration: clinical characteristics of NIHL from steady-state noise exposure
Inflection points in hearing deterioration: clinical characteristics of NIHL from steady-state noise exposure Open
Hearing loss caused by long-term exposure to steady-state noise showed evident deterioration after 4-5 years. The DPOAE can illustrate the inflection point of hearing deterioration 1 year earlier than PTA. Int J Occup Med Environ Health. 2…
View article: FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma
FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma Open
Rationale: Renal cell carcinoma (RCC) is a highly malignant and common urological tumor. In our previous study, we reported the upregulation of PRR11 in RCC, emphasizing its important role in cell cycle regulation and apoptosis. In this fo…
View article: A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review
A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review Open
Background De novo neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) and few markers are available for screening and monitoring. Potential circulating or fluid markers might facilitate early diagnosis thus im…
View article: Insights into anesthesia administration for elderly individuals undergoing painless gastroenteroscopy: A bibliometric study
Insights into anesthesia administration for elderly individuals undergoing painless gastroenteroscopy: A bibliometric study Open
BACKGROUND Administering anesthesia to elderly patients undergoing gastroenteroscopy necessitates careful attention due to age-related physiological changes and an increased risk of complications. AIM To analyze the research trends in anes…
View article: Enhanced recovery after surgery protocol optimizes results and cost of laparoscopic radical nephroureterectomy
Enhanced recovery after surgery protocol optimizes results and cost of laparoscopic radical nephroureterectomy Open
Purpose To evaluate the efficacy of an enhanced recovery after surgery (ERAS) strategy for upper tract urothelial carcinoma (UTUC) patients undergoing laparoscopic radical nephroureterectomy (LRNU). Methods 90 patients who received LRNU at…
View article: Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions
Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions Open
Transcatheter aortic valve replacement (TAVR) is widely recommended and applied among patients with severe aortic stenosis. However, considering the complicated situation of patients after TAVR, Cardiac rehabilitation (CR), as a well-estab…
View article: E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production
E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production Open
Aldosterone-producing adenoma (APA) is a leading cause of primary aldosteronism (PA), a condition marked by excessive aldosterone secretion. CYP11B2, the aldosterone synthase, plays a critical role in aldosterone biosynthesis and the devel…
View article: Global, regional, and national burden of ischemic stroke attributable to active smoking, 1990-2021
Global, regional, and national burden of ischemic stroke attributable to active smoking, 1990-2021 Open
This study highlights the significant global burden of ischemic stroke attributable to active smoking and the critical need for targeted smoking cessation programs and stroke prevention strategies. Despite overall declines in ASMR and age-…
View article: The detection, biological function, and liquid biopsy application of extracellular vesicle-associated DNA
The detection, biological function, and liquid biopsy application of extracellular vesicle-associated DNA Open
Cell-derived extracellular vesicles (EVs), which carry diverse biomolecules such as nucleic acids, proteins, metabolites, and lipids reflecting their cell of origin, are released under both physiological and pathological conditions. EVs ha…