Explanipedia

On Accurate and Robust Estimation of 3D and 2D Circular Center: Method and Application to Camera-Lidar Calibration Open

Jiajun Jiang, Xiao Hu, Wancheng Liu, Wei Jiang · 2025

Circular targets are widely used in LiDAR-camera extrinsic calibration due to their geometric consistency and ease of detection. However, achieving accurate 3D-2D circular center correspondence remains challenging. Existing methods often f…

Integrative analysis of single-cell and transcriptome RNA sequencing to establish a NAT10-related signature for prognostic prediction of uveal melanoma Open

Wancheng Liu, Ying Xu · 2025

Uveal melanoma (UVM), an intraocular malignant tumor originating from uveal melanocytes, not only induces blindness but also exhibits a high fatality risk. Despite the emergence of numerous local treatment modalities for UM in recent years…

EP300 compromises antitumor immunity by increasing SOCS1 expression Open

Yanqiong Zeng, Ying Zhou, Jiayin Ruan, Wancheng Liu, Huimin Fan , et al. · 2025

Background Beyond supporting cancer cell proliferation, tumor growth relies on the ability of cancer cells to evade immune surveillance. Identifying novel molecules that promote tumor immune escape may help develop more effective immunothe…

Application of artificial intelligence in assisting treatment of gynecologic tumors: a systematic review Open

Limin Guo, Shuaitong Zhang, Hongbo Chen, Yifu Li, Yang Liu , et al. · 2025

Polymorphisms of mismatch repair pathway genes predict clinical outcomes in acute myeloid leukemia patients Open

Amin Zhang, Wancheng Liu, Can Can, Xiaodong Guo, Hexiao Jia , et al. · 2025

Targeting the KLF5/PI3K/AKT axis as a therapeutic strategy to overcome neoadjuvant chemoresistance in colorectal cancer Open

Meiling Gao, Junyan Qian, Ping Xia, Wancheng Liu, Yicheng Jiang , et al. · 2025

Background Oxaliplatin-based neoadjuvant chemotherapy (NAC) is the standard treatment for advanced colorectal cancer (CRC), yet resistance to NAC poses a significant clinical challenge. Methods To investigate the mechanisms of chemoresista…

CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy Open

Yu Chen, Wancheng Liu, Qiaomei Cai, Chaohu Pan, Zhengfeng Yin , et al. · 2025

Introduction CDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether…

Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity Open

Can Can, Xinyu Yang, Hexiao Jia, Hanyang Wu, Xiaodong Guo , et al. · 2025

We demonstrate a self-driven progression mediated by exosomal circRNAs and CD8⁺ T cells, highlighting the potential of targeting circRNAs in AML immunotherapy.

The Abnormal Profile of Gut Virome Correlates to Gut Bacterial Dysbiosis and Poor Prognosis in Patients with Diffuse Large B-Cell Lymphoma Open

Daoxin Ma, Hailei Zhang, Na He, Xiaodong Guo, Wancheng Liu , et al. · 2025

COVID-19 mitigates the response to TKIs in patients with CML via the inhibition of T-cell immunity Open

Na He, Guosheng Li, Jinting Liu, Wancheng Liu, Ruifeng Tian , et al. · 2024

Introduction Chronic myeloid leukemia (CML) is a severe hematological malignancy characterized by BCR-ABL fusion gene. The advent of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has improved the landscape of CML treatment dramatical…

Inhibition of NAT10 Enhances the Antitumor Immunity by Increasing Type I Interferon Responses Open

Daoxin Ma, Wancheng Liu, Yihong Wei, Jinfeng Chen, Hexiao Jia , et al. · 2024

Posttranslational modifications add tremendous complexity to cancer progression; however, gaps remain in knowledge regarding the function and immune regulatory mechanism of newly discovered mRNA acetylation modification. Here, we discovere…

Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion Open

Qiaomei Cai, Nina Sun, Yurui Zhang, Jingfeng Wang, Chaohu Pan , et al. · 2024

DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway Open

Huimin Fan, Wancheng Liu, Yanqiong Zeng, Ying Zhou, Meiling Gao , et al. · 2023

CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism responsible for tumor suppression by CDK4/6 blockade. Clinical datase…

Hematopoietic stem cells suppress proliferation and enhance differentiation of leukemia cells through regulating apoptotic and inflammatory genes Open

Bo Li, Can Can, Wancheng Liu, Xiaodong Guo, Hanyang Wu , et al. · 2023

Mitochondrial transfer in hematological malignancies Open

Xiaodong Guo, Can Can, Wancheng Liu, Yihong Wei, Xinyu Yang , et al. · 2023

Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochond…

The genetic polymorphisms of immune‐related genes contribute to the susceptibility and survival of lymphoma Open

Chaoyang Gu, Can Can, Jinting Liu, Yihong Wei, Xinyu Yang , et al. · 2023

Background Though immunological abnormalities have been proven involved in the pathogenesis of lymphoma, the underlying mechanism remains unclear. Methods We investigated 25 single nucleotide polymorphisms (SNPs) of 21 immune‐related genes…

Supplementary Table from CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses Open