Wanchun Wang
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View article: Exploring the interaction mechanisms of CD46/TREM1 and LC3B/ATG5 in the inflammation-cancer transformation of oral squamous cell carcinoma based on bioinformatics
Exploring the interaction mechanisms of CD46/TREM1 and LC3B/ATG5 in the inflammation-cancer transformation of oral squamous cell carcinoma based on bioinformatics Open
Objective To investigate the molecular interaction patterns between CD46/TREM1 and LC3B/ATG5 in the development of oral squamous cell carcinoma (OSCC), providing novel targets for elucidating the mechanism of inflammatory-to-cancer progres…
View article: Risk Factors for Drug-Induced Acute Generalized Exanthematous Pustulosis(AGEP) from 2004 to 2024: A Real-World Study Based on the FAERS
Risk Factors for Drug-Induced Acute Generalized Exanthematous Pustulosis(AGEP) from 2004 to 2024: A Real-World Study Based on the FAERS Open
This study identified multiple drug classes significantly associated with AGEP using FAERS-based adverse event data. The findings highlight a higher susceptibility in middle-aged and younger populations and underscore the importance of enh…
View article: Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report
Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report Open
This case report describes an instance of oral mucosal hypersensitive reaction resembling oral lichenoid reaction (OLR) induced by the use of a whitening toothpaste in a 28-year-old female patient presenting with extensive white hypersensi…
View article: The Synergistic and Attenuated Mechanism of Action of the Xihuang Pill in Dual Immunotherapy After Stenting for Advanced Cholangiocarcinoma: A Controlled Clinical Trial
The Synergistic and Attenuated Mechanism of Action of the Xihuang Pill in Dual Immunotherapy After Stenting for Advanced Cholangiocarcinoma: A Controlled Clinical Trial Open
Xihuang Pill combined with dual immunotherapy can synergistically enhance anti-tumor efficacy and reduce treatment-related toxicity in patients with advanced CCA by regulating coagulation function and immune mechanisms.
View article: CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma
CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma Open
Objective This study aims to explore the regulatory effect of abnormal expression of CD46 and TREM1 on LC3B and ATG5 and to provide new targets for the molecular mechanism and treatment of OSCC. Methods Human oral squamous cell carcinoma c…
View article: Analysis of the Clinical Efficacy of Interlock Detachable Coil Interventional Embolization on Pelvic Congestion Syndrome and Ovarian Reserve Function: A Retrospective Study
Analysis of the Clinical Efficacy of Interlock Detachable Coil Interventional Embolization on Pelvic Congestion Syndrome and Ovarian Reserve Function: A Retrospective Study Open
A combination of precise interventional embolization and endocrine hormone therapy can rapidly and effectively relieve pain in patients with PCS. Compared with free coil embolization, this combination can effectively increase vascular tens…
View article: Smart Near-Infrared Manganese-Doped Carbon Dot-Microneedle Assemblies for Tumor Microenvironment-Activated Photodynamic-Chemodynamic Combined Therapy
Smart Near-Infrared Manganese-Doped Carbon Dot-Microneedle Assemblies for Tumor Microenvironment-Activated Photodynamic-Chemodynamic Combined Therapy Open
View article: Gut Microbiota’s role in lipoma development: evidence from mendelian randomization
Gut Microbiota’s role in lipoma development: evidence from mendelian randomization Open
Background Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients’ physical and psychological wellbeing. Increasing evidence points to a strong link between the gut microbiome (GM) and lipoma incidence. This…
View article: The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis
The mechanism of low molecular weight fucoidan-incorporated nanofiber scaffolds inhibiting oral leukoplakia via SR-A/Wnt signal axis Open
Oral leukoplakia (OLK) is the most common oral precancerous lesion, and 3%–17% of OLK patients progress to oral squamous cell carcinoma. OLK is susceptible to recurrence and has no effective treatment. However, conventional drugs have sign…
View article: Poly(Lysine)-Derived Carbon Quantum Dots Conquer Enterococcus faecalis Biofilm-Induced Persistent Endodontic Infections
Poly(Lysine)-Derived Carbon Quantum Dots Conquer Enterococcus faecalis Biofilm-Induced Persistent Endodontic Infections Open
Thus, PL-CQDs provide a new strategy for treating E. faecalis-associated PEIs.
View article: A Survey of Personalized News Recommendation
A Survey of Personalized News Recommendation Open
Personalized news recommendation is an important technology to help users obtain news information they are interested in and alleviate information overload. In recent years, news recommendation has been increasingly widely studied and has …
View article: Isovitexin Suppresses Cancer Stemness Property and Induces Apoptosis of Osteosarcoma Cells by Disruption of the DNMT1/miR-34a/Bcl-2 Axis [Retraction]
Isovitexin Suppresses Cancer Stemness Property and Induces Apoptosis of Osteosarcoma Cells by Disruption of the DNMT1/miR-34a/Bcl-2 Axis [Retraction] Open
[This retracts the article DOI: 10.2147/CMAR.S222708.].
View article: Carbon dots as a new root canal disinfection against Enterococcus faecalis biofilm-induced persistent endodontic infections
Carbon dots as a new root canal disinfection against Enterococcus faecalis biofilm-induced persistent endodontic infections Open
Persistent endodontic infections (PEIs) mediated by bacterial biofilm are the main cause of persistent periapical inflammation, resulting in recurrent periapical abscesses and progressive bone destruction. However, conventional root canal …
View article: Association of NCAP family genes with prognosis and immune infiltration of human sarcoma
Association of NCAP family genes with prognosis and immune infiltration of human sarcoma Open
The six members of NCAP gene family can be used as biomarkers to predict the prognosis of sarcoma. They were also correlated with the low immune infiltration in sarcoma.
View article: Microneedle patches containing mesoporous polydopamine nanoparticles loaded with triamcinolone acetonide for the treatment of oral mucositis
Microneedle patches containing mesoporous polydopamine nanoparticles loaded with triamcinolone acetonide for the treatment of oral mucositis Open
Oral mucositis (OM) is the most common disease of the oral mucosa, which affects people’s daily production and life. Triamcinolone ointment is the common clinical drug for OM treatment. However, the hydrophobic properties of triamcinolone …
View article: Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study
Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study Open
View article: Hypoxia mitigation by manganese-doped carbon dots for synergistic photodynamic therapy of oral squamous cell carcinoma
Hypoxia mitigation by manganese-doped carbon dots for synergistic photodynamic therapy of oral squamous cell carcinoma Open
Photodynamic therapy (PDT) is widely used for cancer treatment due to its non-invasive and precise effectiveness, however, hypoxia in the tumor microenvironment greatly limits the efficacy of photodynamic therapy. Compared with conventiona…
View article: Correction: therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target
Correction: therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target Open
View article: Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study
Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study Open
View article: Association of SMC4 with prognosis and immune infiltration of sarcoma
Association of SMC4 with prognosis and immune infiltration of sarcoma Open
Several databases including ONCOMINE, GEPIA, and Kaplan-Meier Plotter were adopted to explore the expression pattern of SMC4 in sarcoma, which was confirmed by IHC. The GEPIA and TIMER datasets were adopted to investigate the associ…
View article: RNA sequencing analysis reveals the potential therapeutic mechanisms of Huzhang Tongfeng granule in MSU-induced acute gouty arthritis mouse model
RNA sequencing analysis reveals the potential therapeutic mechanisms of Huzhang Tongfeng granule in MSU-induced acute gouty arthritis mouse model Open
Background: Gout is one of the most prevailing inflammatory arthritis, in which joint pain and dysfunction may drastically reduce patients' quality of life, work efficiency, and increase the burden of medical treatment. The Huzhang Tongfen…
View article: Association between glucosamine use and cancer mortality: A large prospective cohort study
Association between glucosamine use and cancer mortality: A large prospective cohort study Open
Objective Previous studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers b…
View article: On-Demand Release of Fucoidan from a Multilayered Nanofiber Patch for the Killing of Oral Squamous Cancer Cells and Promotion of Epithelial Regeneration
On-Demand Release of Fucoidan from a Multilayered Nanofiber Patch for the Killing of Oral Squamous Cancer Cells and Promotion of Epithelial Regeneration Open
Oral squamous cell carcinoma represents 90% of all oral cancers. Recurrence prevention remains an important prognostic factor in patients with oral squamous cell carcinoma, and the recovery of the oral epithelium post-surgery is still a ch…
View article: Impaction Bone Grafting with Low Dose Irradiated Freeze‐Dried Allograft Bone for Acetabular Reconstruction
Impaction Bone Grafting with Low Dose Irradiated Freeze‐Dried Allograft Bone for Acetabular Reconstruction Open
Objective Reconstruction of acetabular defects has been extremely challenging in both primary and revision total hip arthroplasty (THA). Impaction bone grafting (IBG) can restore the acetabulum bone mass and anatomically reconstruct the ac…
View article: Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma
Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma Open
In terms of the expression levels of mRNA for GINS family members, a particular contrast in various cancers, especially human sarcoma, was conducted through ONCOMINE and GEPIA and CCLE databases. Kaplan-Meier Plotter was used to identify t…
View article: Arthroscopic Management of Giant Meniscal Cysts Among Young Patients: An Average Three‐Year<scp>MRI</scp>Follow‐Up
Arthroscopic Management of Giant Meniscal Cysts Among Young Patients: An Average Three‐Year<span>MRI</span>Follow‐Up Open
Objective To describe an arthroscopic technique for giant meniscal cyst excision with preservation of the functional meniscus, report the short‐ and medium‐term outcomes, and assess magnetic resonance imaging (MRI) for follow‐up imaging ev…
View article: Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis
Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis Open
The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples …
View article: Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-β/SMAD signaling pathway
Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-β/SMAD signaling pathway Open
JDHXD might improve CNBP injury through suppressing inflammation response, ROS, and apoptosis by targeting TGF-β/SMAD signaling pathway. This research might provide a new thought for the prevention and treatment of CNBP through inhibiting …
View article: Integrative analysis of expression, prognostic significance and immune infiltration of RFC family genes in human sarcoma
Integrative analysis of expression, prognostic significance and immune infiltration of RFC family genes in human sarcoma Open
The expression of RFCs was analyzed using the ONCOMINE dataset and GEPIA dataset. CCLE dataset was used to assess the expression of RFCs in the cancer cell line. The prognostic value of RFCs was evaluated by GEPIA and Kaplan-Meier analysis…
View article: Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia
Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia Open
The pain and fear caused by direct local injection of anesthetic or the poor experience with surface anesthetic cream increase the difficulty of clinical treatment for oral diseases. To address this problem, a hyaluronic acid microneedle p…