Chien‐Fu Hung
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View article: Personalizing DNA Cancer Vaccines
Personalizing DNA Cancer Vaccines Open
Recent progress in tumor immunotherapy highlights the important role of the immune system in combating various cancers. Traditionally designed to protect against infectious diseases, vaccines are now being adapted to stimulate immune respo…
View article: Secular trends and survival impact of high proportion of curative treatments for hepatocellular carcinoma in Taiwan, 2011–2019
Secular trends and survival impact of high proportion of curative treatments for hepatocellular carcinoma in Taiwan, 2011–2019 Open
The proportion of curative treatments in Taiwan has increased, potentially improving survival outcomes across all BCLC stages.
View article: Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC
Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC Open
Human papillomavirus associated head and neck cancer (HPV + HNC) is rising globally, emphasizing the need for improved therapeutic and screening strategies. To test novel therapies and study HPV-related disease progression, it is vital to …
View article: Type I Interferon Modulates the Function of Ly6C High-Expressing Naïve CD8+ T Cells to Promote an Antitumor Response
Type I Interferon Modulates the Function of Ly6C High-Expressing Naïve CD8+ T Cells to Promote an Antitumor Response Open
Background: Ly6C expression in naïve CD8+ T cells plays a crucial role in enhancing their effector activity, suggesting potential implications for cancer immunotherapy. This study investigates the functional impact of Ly6C expression on CD…
View article: Clinicopathologic Features and Viral Status of Low-risk HPV6 and HPV11-Associated Squamous Cell Carcinoma of the Uterine Cervix and Vulva
Clinicopathologic Features and Viral Status of Low-risk HPV6 and HPV11-Associated Squamous Cell Carcinoma of the Uterine Cervix and Vulva Open
Despite being designated as “noncarcinogenic” human papillomavirus (HPV) types, mono-infection with HPV6 or HPV11 has been found in squamous cell carcinomas (SCCs) at specific sites, including the larynx, penis, anus, and rarely, the lower…
View article: MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis
MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis Open
Typical epidermodysplasia verruciformis (EV) is a rare, autosomal recessive disorder characterized by an unusual susceptibility to infection with specific skin-trophic types of human papillomavirus, principally betapapillomaviruses , and a…
View article: Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods
Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods Open
View article: Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer
Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer Open
View article: The efficacy of rituximab in the treatment of refractory chronic inflammatory demyelinating polyneuropathy in children: A report of three cases from Northern Vietnam
The efficacy of rituximab in the treatment of refractory chronic inflammatory demyelinating polyneuropathy in children: A report of three cases from Northern Vietnam Open
Rituximab has been reported to be effective in patients with refractory CIDP, especially those with IgG4 autoantibodies against nodal and paranodal proteins. This study reports the clinical characteristics of three cases diagnosed with ref…
View article: Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens
Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens Open
Recent breakthroughs in cancer immunotherapies have emphasized the importance of harnessing the immune system for treating cancer. Vaccines, which have traditionally been used to promote protective immunity against pathogens, are now being…
View article: Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine
Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine Open
Background Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel cancer immunotherapy strategy due to its in…
View article: STAT1-Deficient HPV E6/E7-Associated Cancers Maintain Host Immunocompetency against Therapeutic Intervention
STAT1-Deficient HPV E6/E7-Associated Cancers Maintain Host Immunocompetency against Therapeutic Intervention Open
Human papillomavirus (HPV) remains a global health concern because it contributes to the initiation of various HPV-associated cancers such as anal, cervical, oropharyngeal, penile, vaginal, and vulvar cancer. In HPV-associated cancers, onc…
View article: CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers
CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers Open
Somatic mutations are desirable targets for selective elimination of cancer, yet most are found within noncoding regions. We have adapted the CRISPR-Cas9 gene editing tool as a novel, cancer-specific killing strategy by targeting the subse…
View article: FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors Open
View article: Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies
Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies Open
Background MUC16 is a heavily glycosylated cell surface mucin cleaved in the tumor microenvironment to shed CA125. CA125 is a serum biomarker expressed by > 95% of non-mucinous advanced stage epithelial ovarian cancers. MUC16/CA125 contrib…
View article: Profiling of VEGF Receptors and Immune Checkpoints in Recurrent Respiratory Papillomatosis
Profiling of VEGF Receptors and Immune Checkpoints in Recurrent Respiratory Papillomatosis Open
Objectives Recurrent respiratory papillomatosis (RRP) is caused by human papilloma virus (HPV) infection of the aerodigestive tract that significantly impacts quality‐of‐life including the ability to communicate and breathe. Treatment was …
View article: <i>Salmonella</i> immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy
<i>Salmonella</i> immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy Open
Bacteria-based cancer therapy employs various strategies to combat tumors, one of which is delivering tumor-associated antigen (TAA) to generate specific immunity. Here, we utilized a poly-arginine extended HPV E7 antigen (9RE7) for attach…
View article: In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy
In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy Open
Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable for T cell activation, so there is a res…
View article: Immune responses, therapeutic anti-tumor effects, and tolerability upon therapeutic HPV16/18 E6/E7 DNA vaccination via needle-free biojector
Immune responses, therapeutic anti-tumor effects, and tolerability upon therapeutic HPV16/18 E6/E7 DNA vaccination via needle-free biojector Open
Intramuscular vaccination of mice with the naked pBI-11 DNA plasmid targeting E6 and E7 of HPV16 and HPV18 via a conventional syringe and needle generates human papillomavirus (HPV) antigen-specific CD8+ T cell-mediated immune responses an…
View article: Multidisciplinary Taiwan consensus for the use of conventional TACE in hepatocellular carcinoma treatment
Multidisciplinary Taiwan consensus for the use of conventional TACE in hepatocellular carcinoma treatment Open
Developed in early 1980s, transarterial chemoembolization (TACE) with Lipiodol was adopted globally after large-scale randomized control trials and meta-analyses proving its effectiveness were completed. Also known as “conventional TACE” (…
View article: Supplementary Figure 2 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ
Supplementary Figure 2 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ Open
PDF file - 81K, Characterization of tumor infiltrating T cells following treatment with systemic DNA vaccination and locally applied imiquimod.
View article: SSupplementary Figure 1 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ
SSupplementary Figure 1 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ Open
PDF file - 70K, E7-specific T cells efficiently migrated from circulation to the genital tract following imiquimod application.
View article: Supplemental Figure 2 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ
Supplemental Figure 2 from Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8<sup>+</sup> T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFNγ Open
Supplemental Figure 2. Characterization of tumor infiltrating T cells following treatment with systemic DNA vaccination and locally applied imiquimod
View article: Supplementary Figure 4 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Supplementary Figure 4 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors Open
PDF file - 941K, Characterization of E7-specific CD8+ T cell activation in tumor-bearing mice treated with radiation and intratumoral vaccination with E7 peptide.
View article: Supplementary Data from Combination of Viral Oncolysis and Tumor-Specific Immunity to Control Established Tumors
Supplementary Data from Combination of Viral Oncolysis and Tumor-Specific Immunity to Control Established Tumors Open
Supplementary Data from Combination of Viral Oncolysis and Tumor-Specific Immunity to Control Established Tumors
View article: Table S4 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics
Table S4 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics Open
Supplementary Table S4
View article: Supplementary Figure Legends from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8<sup>+</sup> T-cell–Mediated Tumor Control in the Genital Tract
Supplementary Figure Legends from Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8<sup>+</sup> T-cell–Mediated Tumor Control in the Genital Tract Open
Supplementary Figure Legends
View article: Supplementary Figure 9 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
Supplementary Figure 9 from Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors Open
PDF file - 2078K, Characterization of antigen-specific CD8+ T cells immune responses and antitumor effects in TC-1 tumor-bearing mice treated with radiation therapy and intratumoral vaccination with OVA peptide.
View article: Data from HLA-DQB1*02–Restricted HPV-16 E7 Peptide–Specific CD4<sup>+</sup> T-Cell Immune Responses Correlate with Regression of HPV-16–Associated High-Grade Squamous Intraepithelial Lesions
Data from HLA-DQB1*02–Restricted HPV-16 E7 Peptide–Specific CD4<sup>+</sup> T-Cell Immune Responses Correlate with Regression of HPV-16–Associated High-Grade Squamous Intraepithelial Lesions Open
Purpose: The fact that up to 30% of established high-grade squamous intraepithelial lesions (HSIL) of the cervix regress spontaneously presents the opportunity to identify clinically relevant human papillomavirus (HPV) viral epitope…
View article: Table S1 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics
Table S1 from Lineage-Specific Alterations in Gynecologic Neoplasms with Choriocarcinomatous Differentiation: Implications for Origin and Therapeutics Open
Supplementary Table S1