Yanchun Wang
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View article: Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer Open
Tertiary lymphoid structures (TLSs) have emerged as critical prognostic and immunotherapeutic indicators in cancer, with their clinical significance modulated by spatial distribution patterns and density. Here, we performed integrated sing…
View article: Highly Efficient and Stable Binary‐Doped Narrowband Blue OLEDs Enabled by a Single‐Component Host Matrix with a Spatial Bipolarity Configuration
Highly Efficient and Stable Binary‐Doped Narrowband Blue OLEDs Enabled by a Single‐Component Host Matrix with a Spatial Bipolarity Configuration Open
Highly efficient and stable narrowband blue organic light‐emitting diodes (OLEDs) are vital for high‐definition displays, yet the achievement of such devices via a concise binary‐doped fabrication architecture remains challenging. Herein, …
View article: Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis
Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis Open
Hyperglycemia exacerbates diabetic chronic wounds by inducing oxidative damage and epithelial-mesenchymal transition (EMT), impairing re-epithelialization. This study investigated the protective role of adipose-derived mesenchymal stem cel…
View article: Response of Soil Properties, Bacterial Community Structure, and Function to Mulching Practices in Urban Tree Pits: A Case Study in Beijing
Response of Soil Properties, Bacterial Community Structure, and Function to Mulching Practices in Urban Tree Pits: A Case Study in Beijing Open
Soil degradation and poor fertility severely constrain vegetation growth in urban ecosystems, particularly in compacted and nutrient-depleted tree pits. Mulching has emerged as an effective strategy to improve soil quality and regulate soi…
View article: Propolis Modulates the Gut Microbiota–Gut Hormone–Liver AMPK Axis to Ameliorate High-Fat Diet-Induced Metabolic Disorders in Rats
Propolis Modulates the Gut Microbiota–Gut Hormone–Liver AMPK Axis to Ameliorate High-Fat Diet-Induced Metabolic Disorders in Rats Open
Objectives: Emerging evidence suggests that propolis possesses significant anti-obesity properties. While gut hormones and microbiota are known to play crucial roles in obesity development, the specific mechanisms through which propolis ex…
View article: Prognostic value and molecular mechanism of photodynamic therapy and apoptosis related gene FGFR1 in bladder cancer
Prognostic value and molecular mechanism of photodynamic therapy and apoptosis related gene FGFR1 in bladder cancer Open
Purpose Photodynamic therapy (PDT) is an innovative non-invasive therapy for human cancer treatment. The significance of apoptosis-related genes (ARGs) in the prognosis of bladder cancer (BLCA) has gradually emerged. Therefore, this study …
View article: The study on the efficacy of improving cancer-related fatigue after the treatment with ginseng Guben Oral liquid
The study on the efficacy of improving cancer-related fatigue after the treatment with ginseng Guben Oral liquid Open
View article: The Impact of Neoadjuvant Chemotherapy on Survival Outcomes in Gastric Signet-Ring Cell Carcinoma: An International Multicenter Study
The Impact of Neoadjuvant Chemotherapy on Survival Outcomes in Gastric Signet-Ring Cell Carcinoma: An International Multicenter Study Open
Background: Gastric signet-ring cell carcinoma (GSRCC) is associated with a poor prognosis, and the effectiveness of neoadjuvant chemotherapy (NAC) in improving survival outcomes remains inconclusive. This study aimed to evaluate the impac…
View article: LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation
LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation Open
Coxsackievirus B5 (CVB5) is a primary causative agent of hand, foot, and mouth disease (HFMD), and some cases are also associated with severe complications through invasion of the central nervous system, resulting in death. Currently, ther…
View article: Establishment and validation of a predictive model for Lobar pneumonia caused by Mycoplasma pneumoniae infection in children
Establishment and validation of a predictive model for Lobar pneumonia caused by Mycoplasma pneumoniae infection in children Open
View article: A Case Report of Pediatric Abdominal Tuberculosis with Intestinal Perforation Misdiagnosed as Malignancy
A Case Report of Pediatric Abdominal Tuberculosis with Intestinal Perforation Misdiagnosed as Malignancy Open
This case highlights the diagnostic complexity of pediatric abdominal TB, particularly when presenting with an abdominal mass complicated by intestinal perforation. Misleading clinical and imaging findings, along with negative immunologica…
View article: Construction of a quality evaluation indicator system for extended care in patients with chronic obstructive pulmonary disease: a cross-sectional study
Construction of a quality evaluation indicator system for extended care in patients with chronic obstructive pulmonary disease: a cross-sectional study Open
Objective The aim of this study was to construct a quality evaluation indicator system for extended care in patients with chronic obstructive pulmonary disease (COPD), provide beneficial references for quality evaluation and practice stand…
View article: Sephin1 alleviates white matter injury by protecting oligodendrocyte after intracerebral hemorrhage
Sephin1 alleviates white matter injury by protecting oligodendrocyte after intracerebral hemorrhage Open
Background White matter injury (WMI) caused by intracerebral hemorrhage (ICH) is a major neuropathological feature closely associated with neurological impairments such as motor and sensory dysfunction. Oligodendrocytes (OLs), which are re…
View article: Author response: Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer
Author response: Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer Open
View article: Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer
Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer Open
Most of the human gastric cancer (GC) worldwide are ascribed to Helicobacter pylori infections, which have a detrimental effect on the immunotherapy’s efficacy. Comprehensively dissecting the key cell players and molecular pathways associa…
View article: Jiaotai pill and its main component enhance islet hormone secretion in type 2 diabetic rats by activating the THP1/TGase2/SERT/5-HT1FRpathway
Jiaotai pill and its main component enhance islet hormone secretion in type 2 diabetic rats by activating the THP1/TGase2/SERT/5-HT1FRpathway Open
Objective: To investigate the relationship between Jiaotai pill (JTP), its main component berberine (BBR), and the serotonin (5-HT) system in regulating islet hormone secretion and alleviating pancreatic β-cell dysfunction during type 2 di…
View article: Author response: Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer
Author response: Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer Open
View article: Engineered Outer Membrane Vesicles for Antigen Delivery: Exploratory Study on Adjuvant Activity and Systemic Reactogenicity
Engineered Outer Membrane Vesicles for Antigen Delivery: Exploratory Study on Adjuvant Activity and Systemic Reactogenicity Open
Background: Outer Membrane Vesicles (OMVs), nanosized particles derived from Gram-negative bacteria, are promising vaccine carriers due to innate immunogenicity and self-adjuvant properties. Yet the systematic evaluations of OMV-associated…
View article: Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer
Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer Open
Most of the gastric cancer (GC) worldwide are ascribed to Helicobacter pylori (H. pylori) infections, which have a detrimental effect on the immunotherapy’s efficacy. Comprehensively dissecting the key cell players and molecular pathways a…
View article: Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer (Adv. Sci. 18/2025)
Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer (Adv. Sci. 18/2025) Open
Gastric Cancer Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang, and co‐workers meticulously conducted an in‐depth and comprehensive exploration of the single‐cell and spatial transcriptomic landscape of gastric cancer initiation and pr…
View article: The prognostic role of vegetation size in pediatric infective endocarditis: a retrospective study using decision curve and dose-response analysis
The prognostic role of vegetation size in pediatric infective endocarditis: a retrospective study using decision curve and dose-response analysis Open
View article: The causal relationship between smoking, alcohol consumption, and sepsis: A 2-sample mendelian randomized study
The causal relationship between smoking, alcohol consumption, and sepsis: A 2-sample mendelian randomized study Open
A Mendelian randomization (MR) study was used to explore whether there is a causal relationship between smoking, alcohol consumption, and sepsis. Genome-wide association studies data on sepsis, alcohol consumption, and 3 smoking behaviors …
View article: A case of scrub typhus encephalitis in a pediatric patient with different serotypes detected in blood and cerebrospinal fluid
A case of scrub typhus encephalitis in a pediatric patient with different serotypes detected in blood and cerebrospinal fluid Open
View article: Surface Display of Type 1 Fimbriae on Shigella flexneri Induces Antigen-Specific Immune Response via Oral Route
Surface Display of Type 1 Fimbriae on Shigella flexneri Induces Antigen-Specific Immune Response via Oral Route Open
Background: Live attenuated bacteria are promising candidates for mucosal vaccine delivery due to their ability to elicit robust immune responses. FimH is the adhesion protein of type 1 fimbriae, which is used as mucosal adjuvants. This st…
View article: Exploration of a GMMA-Based Bivalent Vaccine Against Klebsiella pneumoniae
Exploration of a GMMA-Based Bivalent Vaccine Against Klebsiella pneumoniae Open
Background: An emerging trend of mutual convergence between drug-resistant and highly virulent strains of K. pneumoniae has been identified, highlighting the urgent need for the development of novel vaccines. Methods: To delete the target …
View article: Construction and validation of a predictive model for meningoencephalitis in pediatric scrub typhus based on machine learning algorithms
Construction and validation of a predictive model for meningoencephalitis in pediatric scrub typhus based on machine learning algorithms Open
To retrospectively analyze the clinical characteristics of pediatric scrub typhus (ST) with meningoencephalitis (STME) and to construct and validate predictive models using machine learning.Clinical data were collected from 100 cases of pe…
View article: Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer
Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer Open
Despite significant advancements in identifying novel therapeutic targets and compounds, cancer stem cells (CSCs) remain pivotal in driving therapeutic resistance and tumor progression in gastric cancer (GC). High‐resolution knowledge of t…
View article: Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals
Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals Open
The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear. This study demonstrated d…
View article: A case report of pediatric scrub typhus presenting as acalculous cholecystitis during the non-epidemic season without eschar
A case report of pediatric scrub typhus presenting as acalculous cholecystitis during the non-epidemic season without eschar Open
View article: Dialect-SQL: An Adaptive Framework for Bridging the Dialect Gap in Text-to-SQL
Dialect-SQL: An Adaptive Framework for Bridging the Dialect Gap in Text-to-SQL Open