Jianwei Wang
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View article: Metabolomics-based mechanism of colour change in Cuibi No.1 flue-cured tobacco leaves during early aging
Metabolomics-based mechanism of colour change in Cuibi No.1 flue-cured tobacco leaves during early aging Open
View article: Influence of Soil Hydrological Processes on Different Forms of Nitrogen Output in Red Soil Slope Farmland
Influence of Soil Hydrological Processes on Different Forms of Nitrogen Output in Red Soil Slope Farmland Open
The hydrological processes of red soil slope farmland are complex, and the vertical migration of nitrogen (N) is influenced by these processes, which present different layering characteristics of water flow. Previous studies on the vertica…
View article: Predictive Value of Blood Eosinophil Ratio for Risk Stratification in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Predictive Value of Blood Eosinophil Ratio for Risk Stratification in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps Open
Background Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is associated with severe symptoms and poor outcomes, but the diagnostic criteria remain elusive. The objective of this study is to identify preoperative predictors…
View article: Parents’ preference for the inclusion of pediatric vaccines in the Chinese National Immunization Program: A discrete choice experiment
Parents’ preference for the inclusion of pediatric vaccines in the Chinese National Immunization Program: A discrete choice experiment Open
The National Immunization Program (NIP) has significantly improved public health in China. However, current NIP coverage does not fully meet China's disease prevention needs. Some pediatric vaccines recommended by the World Health Organiza…
View article: Vegetation evolution and water sensitivity analysis in the source region of the Yangtze River and the Yellow River under the combined drive of energy-temperature-water
Vegetation evolution and water sensitivity analysis in the source region of the Yangtze River and the Yellow River under the combined drive of energy-temperature-water Open
Due to the combined effects of energy distribution, temperature change and water phase transition, the vegetation eco-hydrological process in the source region of the Yangtze River and Yellow River is highly sensitive to climate change, an…
View article: Development of a LASSO dynamic prediction system for interbody cage subsidence following OLIF surgery
Development of a LASSO dynamic prediction system for interbody cage subsidence following OLIF surgery Open
Cage subsidence after oblique lumbar interbody fusion (OLIF) frequently causes poor outcomes, yet existing predictive models lack accuracy and applicability. This study leveraged the Least Absolute Shrinkage and Selection Operator (LASSO) …
View article: TRPML1 Controls Mitochondrial Homeostasis and Alleviates Cardiac Hypertrophy by Inhibiting VDAC1 Oligomerization
TRPML1 Controls Mitochondrial Homeostasis and Alleviates Cardiac Hypertrophy by Inhibiting VDAC1 Oligomerization Open
View article: Prevalence and risk factors of lung nodules in a non-smoking Chinese population: A prospective study of low-dose computed tomography screening
Prevalence and risk factors of lung nodules in a non-smoking Chinese population: A prospective study of low-dose computed tomography screening Open
Background: Low-dose computed tomography (LDCT) has significantly improved early detection of lung cancer, especially among high-risk populations. However, the risk factors and lung nodule distributions in non-smoking populations remain un…
View article: PrediQL: Automated Testing of GraphQL APIs with LLMs
PrediQL: Automated Testing of GraphQL APIs with LLMs Open
GraphQL's flexible query model and nested data dependencies expose APIs to complex, context-dependent vulnerabilities that are difficult to uncover using conventional testing tools. Existing fuzzers either rely on random payload generation…
View article: Application of deep learning-based convolutional neural networks in gastrointestinal disease endoscopic examination
Application of deep learning-based convolutional neural networks in gastrointestinal disease endoscopic examination Open
Gastrointestinal (GI) diseases, including gastric and colorectal cancers, significantly impact global health, necessitating accurate and efficient diagnostic methods. Endoscopic examination is the primary diagnostic tool; however, its accu…
View article: Gan-du-qing attenuates PM2.5-induced Chronic Airway Inflammation via regulating the pulmonary microbiota and metabolic profiles
Gan-du-qing attenuates PM2.5-induced Chronic Airway Inflammation via regulating the pulmonary microbiota and metabolic profiles Open
Background Substantial evidence links fine particulate matter (PM 2.5 ) to the development of inflammatory lung diseases such as chronic airways, but effective treatments are lacking. Gan-du-qing (GDQ) Decoction is a traditional Chinese me…
View article: Customized Retrieval-Augmented Generation with LLM for Debiasing Recommendation Unlearning
Customized Retrieval-Augmented Generation with LLM for Debiasing Recommendation Unlearning Open
Modern recommender systems face a critical challenge in complying with privacy regulations like the 'right to be forgotten': removing a user's data without disrupting recommendations for others. Traditional unlearning methods address this …
View article: COPS8-Mediated Deneddylation of DHX9 Enhances Radioresistance in Non-Small Cell Lung Cancer via Facilitating DNA Damage Repair
COPS8-Mediated Deneddylation of DHX9 Enhances Radioresistance in Non-Small Cell Lung Cancer via Facilitating DNA Damage Repair Open
View article: Effects of chronic administrations of aconitine on digestive tract and Serum metabolism in mice
Effects of chronic administrations of aconitine on digestive tract and Serum metabolism in mice Open
View article: Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease
Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease Open
The characteristic asymmetric motor symptoms of Parkinson's disease (PD) may be associated with asymmetric deposition of α-synuclein. The impaired glymphatic system may promote pathological deposition of α-synuclein, leading to disease pro…
View article: Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop
Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop Open
Aging-related accumulation of DNA damage adversely affects hematopoietic stem cell (HSC). However, the mechanisms underlying this accumulation and strategies for its elimination to rejuvenate aged HSCs remain largely obscure. This study un…
View article: Histone marks enable formation of immiscible phase-separated chromatin compartments
Histone marks enable formation of immiscible phase-separated chromatin compartments Open
Eukaryotic chromatin is organized into compartments for gene expression regulation, but the underlying mechanisms remain unclear. Here, we demonstrate that multivalent H3K27me3 and its reader, the CBX7-PRC1 complex, regulate facultative he…
View article: Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset
Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset Open
Background Hypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to de…
View article: Host lncRNA assists the nuclear import of influenza A virus protein PB2 in a species-specific manner
Host lncRNA assists the nuclear import of influenza A virus protein PB2 in a species-specific manner Open
Long noncoding RNAs (lncRNAs) have been reported to modulate immune responses to viral infections. However, it remains largely unexplored how viruses exploit host lncRNAs to promote viral replication. Here, we found that an lncRNA, called …
View article: Comprehensive review of Bayesian network applications in gastrointestinal cancers
Comprehensive review of Bayesian network applications in gastrointestinal cancers Open
Gastrointestinal cancers, including esophageal, gastric, colorectal, liver, gallbladder, cholangiocarcinoma, and pancreatic cancers, pose a significant global health challenge due to their high mortality rates and poor prognosis, particula…
View article: UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation
UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation Open
Since the outbreak of SARS-CoV-2, viral mutations have posed significant challenges in identifying therapeutic targets and developing broad-spectrum antiviral drugs. Post-translational modifications of genes involved in interferon producti…
View article: Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization
Chronic Lung Diseases and Depressive Symptoms in Older Adults: Insights from Observational Studies and Mendelian Randomization Open
Depressive symptoms are associated with an increased risk of CLDs, reduced BADL promote the risk of CLDs in older adults with depressive symptoms, but the underlying pathological mechanism still needs to be clarified in future research.
View article: hnRNPM regulates influenza A virus replication through distinct mechanisms in human and avian cells: implications for cross-species transmission
hnRNPM regulates influenza A virus replication through distinct mechanisms in human and avian cells: implications for cross-species transmission Open
The eight-segmented RNA genome of influenza A virus (IAV) is transcribed and spliced into 10 major viral mRNAs in the nucleus of infected cells. Both transcription and splicing are facilitated by the host RNA polymerase II (Pol II) machine…
View article: A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection
A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection Open
Dissecting host factors critical for viral infection and understanding their mechanisms of action is critical for identifying drug targets. Here, we leverage a genome-wide CRISPR base-editing screen to identify functional lysine residues i…
View article: Integrated Analysis of Disulfidptosis-Related Genes Identifies CD2AP as a Potential Therapeutic Target for Hepatocellular Carcinoma
Integrated Analysis of Disulfidptosis-Related Genes Identifies CD2AP as a Potential Therapeutic Target for Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a deadly cancer with limited treatment options for patients at advanced stages. It is urgent to develop reliable prognostic risk models and identify more biomarkers to improve the clinical outcomes of pati…
View article: Transmission of the human respiratory microbiome and antibiotic resistance genes in healthy populations
Transmission of the human respiratory microbiome and antibiotic resistance genes in healthy populations Open
In summary, we characterized the transmissible nature of the OP microbiome and the risk of ARG dissemination among respiratory microorganisms. These findings underscore the role of respiratory microbes and ARGs exchange in shaping the micr…
View article: Pan-cancer analysis identifies tRNA modification enzyme CTU2 as a novel tumor biomarker and its role in immune microenvironment
Pan-cancer analysis identifies tRNA modification enzyme CTU2 as a novel tumor biomarker and its role in immune microenvironment Open
Background Recent studies have highlighted dysregulated tRNA modifications in the reprogramming of tumor translation. Cytosolic thiouridylase subunit 2 (CTU2) is an essential and conserved enzyme that modifies tRNA at the wobble position. …
View article: Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Network Pharmacology Reveal the Mechanisms of Rhodiola crenulata in Improving Non-Alcoholic Fatty Liver Disease
Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry and Network Pharmacology Reveal the Mechanisms of Rhodiola crenulata in Improving Non-Alcoholic Fatty Liver Disease Open
Rhodiola crenulata (RC) is a traditional herb and functional food that has demonstrated beneficial effects in improving physical function, enhancing work capacity, alleviating fatigue, and preventing altitude sickness. Additionally, RC has…
View article: Clustering and visualisation of the GABRIEL network expertise in the field of infectious diseases
Clustering and visualisation of the GABRIEL network expertise in the field of infectious diseases Open
Introduction The Global Approach to Biology Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL) network is an international scientific network of 21 centres coordinated by the Merieux Foundation (Lyon, France). Ma…
View article: Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments
Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments Open
Background Osteoporosis (OP) represents a widespread bone remodeling disorder within the domain of orthopedics, markedly compromising the quality of life in the elderly population. The need to develop more efficient therapeutic approaches …