Junjun Wang
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View article: YAP contributes to liver injury through mediating capillarization of liver sinusoidal endothelial cells via GATA6/eNOS signaling
YAP contributes to liver injury through mediating capillarization of liver sinusoidal endothelial cells via GATA6/eNOS signaling Open
YAP-GATA6/eNOS signaling is essential in LSEC capillarization and subsequent hepatocyte death. Interventions targeting YAP in LSECs offer a promising strategy for the treatment of liver fibrosis.
View article: Associations of ambient temperature and heat waves with risks of hepatitis E in Jiangsu, China (2010–2023): A time-stratified case-crossover study
Associations of ambient temperature and heat waves with risks of hepatitis E in Jiangsu, China (2010–2023): A time-stratified case-crossover study Open
Short-term exposure to higher ambient temperatures and heat wave events was associated with increased risk of hepatitis E in Jiangsu, China. These results suggest that climate warming and extreme heat may elevate transmission of HEV, under…
View article: Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition
Big Data and AI‐Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition Open
The global livestock production system faces significant challenges for sustainable development, including feed resource shortage and environmental pressures. Precision animal nutrition is crucial in addressing these challenges, in which t…
View article: Vascular risk factors and neuroimaging heterogeneity across different white matter hyperintensities distribution patterns
Vascular risk factors and neuroimaging heterogeneity across different white matter hyperintensities distribution patterns Open
Background Different white matter hyperintensities (WMHs) distribution patterns exhibit distinct clinical implications, but their underlying mechanisms remain unclear. This study explores vascular risk factors and neuroimaging features to …
View article: Unlocking the potential: Exploring the application of bioactive peptides in aquaculture
Unlocking the potential: Exploring the application of bioactive peptides in aquaculture Open
View article: Impact of water vapor on nitrogen fixation in atmospheric pressure O2/N2 plasma jets
Impact of water vapor on nitrogen fixation in atmospheric pressure O2/N2 plasma jets Open
This study investigated the influence of water vapor on the primary nitrogen fixation (NF) products—NO and NO2—produced by atmospheric pressure O2/N2 plasma jets, examining both DC and pulsed discharge modes under varying oxygen-to-nitroge…
View article: Bacillus coagulans Unique IS2 improves stool characteristics in healthy adults with infrequent bowel movements: a randomized, double-blind, placebo-controlled trial
Bacillus coagulans Unique IS2 improves stool characteristics in healthy adults with infrequent bowel movements: a randomized, double-blind, placebo-controlled trial Open
Digestive health issues, including irregular bowel movements (BM) and gastrointestinal (GI) symptoms, affect millions of people in the United States and are associated with higher risks of various diseases. This randomized, double-blind, p…
View article: Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota
Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota Open
Background and Aim Metabolic dysfunction associated steatotic liver disease (MASLD) is the predominant cause of chronic liver disease, with dysregulation of bile acid (BA) metabolism and intestinal microbiota being intricately associated w…
View article: Endogenous Hydrogen Sulphide Promotes the Ex Vivo Expansion of Haematopoietic Stem Cells by Regulating the Activation of the <scp>JAK2</scp>/<scp>STAT3</scp> Pathway
Endogenous Hydrogen Sulphide Promotes the Ex Vivo Expansion of Haematopoietic Stem Cells by Regulating the Activation of the <span>JAK2</span>/<span>STAT3</span> Pathway Open
Haematopoietic stem cell transplantation (HSCT) is one of the key strategies for treating various haematologic malignancies. Although there are haematopoietic stem cells (HSCs) in umbilical cord blood (UCB), the number is limited. Thus, th…
View article: Glucose release kinetics of different feed ingredients and their impact on short-term growth of pigs by influencing carbon-nitrogen supply synchronization
Glucose release kinetics of different feed ingredients and their impact on short-term growth of pigs by influencing carbon-nitrogen supply synchronization Open
Background Pigs fed diets with different ingredients but identical nutritional levels show significant differences in growth performance, indicating that growth may also be influenced by the synchronicity of dietary carbon and nitrogen sup…
View article: Identification of potential metabolic biomarkers and immune cell infiltration for metabolic associated steatohepatitis by bioinformatics analysis and machine learning
Identification of potential metabolic biomarkers and immune cell infiltration for metabolic associated steatohepatitis by bioinformatics analysis and machine learning Open
This study successfully identified seven signature MRDEGs as significant diagnostic biomarkers for MASH. The findings not only offer novel strategies for non-invasive diagnosis of MASH but also highlight the substantial role of immune cell…
View article: The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks
The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks Open
Background Self-limited epilepsy with centrotemporal spikes (SeLECTS), a common childhood focal epilepsy syndrome, is linked to cognitive impairments and poorly understood neuropathological mechanisms. Methods This study explored dynamic f…
View article: Retraction Note: The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death
Retraction Note: The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death Open
View article: Digestion kinetics of protein feed ingredients and their impact on nitrogen utilization in growing pigs
Digestion kinetics of protein feed ingredients and their impact on nitrogen utilization in growing pigs Open
The velocity of nitrogen release impacts nitrogen utilization efficiency and animal growth. Yet the crucial junctures linking nitrogen release and utilization from diverse feed ingredients to digestion kinetic parameters remain obscure. Th…
View article: Dietary Qiwenghuangbo powder–enriched <i>Limosilactobacillus reuteri</i> protects the intestinal epithelium and alleviates inflammation via a strain‐specific mechanism
Dietary Qiwenghuangbo powder–enriched <i>Limosilactobacillus reuteri</i> protects the intestinal epithelium and alleviates inflammation via a strain‐specific mechanism Open
Background Qiwenghuangbo powder (QP), composed of Astragalus , Phellodendron chinensis , and Radix pulsatilla , is a traditional Chinese herbal formula, but its effects on weaned piglets remained unclear. Methods Weaned piglets fed with 0.…
View article: Effects of dietary protein digestion kinetics on sow body condition loss and litter performance during lactation: A meta-analysis
Effects of dietary protein digestion kinetics on sow body condition loss and litter performance during lactation: A meta-analysis Open
View article: Effect of Bacillus subtilis ATCC 122264 on intestinal gas symptoms and quality of life in adults with functional bloating
Effect of Bacillus subtilis ATCC 122264 on intestinal gas symptoms and quality of life in adults with functional bloating Open
Probiotics can confer a beneficial effect on gastrointestinal-related symptoms and their impact on daily life. This randomised, double-blind, placebo-controlled study assessed the efficacy of a novel probiotic strain Bacillus subtilis ATCC…
View article: Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis
Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis Open
Background and purpose Asymptomatic carotid stenosis (ACS) is an independent risk factor for ischemic stroke and vascular cognitive impairment, affecting cognitive function across multiple domains. This study aimed to explore differences i…
View article: Ferulic acid mediates microbial fermentation of arabinoxylan to enhance host immunity by suppressing TLR4/NF-κB signaling
Ferulic acid mediates microbial fermentation of arabinoxylan to enhance host immunity by suppressing TLR4/NF-κB signaling Open
The study was conducted to explore the relationship between arabinoxylan (AX) structure and microbial fermentation characteristics, and reveal molecular mechanism of AX on regulating immune function of the host. Results indicated that the …
View article: Maternal milk fat globule membrane enriched gut <i>L. murinus</i> and circulating SCFAs to improve placental efficiency and fetal development in intrauterine growth restricted mice model
Maternal milk fat globule membrane enriched gut <i>L. murinus</i> and circulating SCFAs to improve placental efficiency and fetal development in intrauterine growth restricted mice model Open
Intrauterine growth restriction (IUGR) caused by placental dysfunctions leads to fetal growth defects. Maternal microbiome and its metabolites have been reported to promote placental development. Milk fat globule membrane (MFGM) is known f…
View article: Facile Preparation of Three-Dimensional Cubic Mnse2 and Application in Aqueous Copper-Ion Batteries
Facile Preparation of Three-Dimensional Cubic Mnse2 and Application in Aqueous Copper-Ion Batteries Open
View article: <i>Muribaculum intestinale</i> restricts <i>Salmonella</i> Typhimurium colonization by converting succinate to propionate
<i>Muribaculum intestinale</i> restricts <i>Salmonella</i> Typhimurium colonization by converting succinate to propionate Open
Insufficient dietary fiber intake is associated with dysbiosis and compromised colonization resistance (CR) to enteric infections. However, a detailed understanding of the relationship between dietary fiber insufficiency and CR remains elu…
View article: No Formation Dynamics in Air Plasma: Diagnostics Using Controlled Long-Pulse Discharge and Laser-Induced
No Formation Dynamics in Air Plasma: Diagnostics Using Controlled Long-Pulse Discharge and Laser-Induced Open
View article: Facile Preparation of Three-Dimensional Cubic Mnse2 and Application in Aqueous Copper-Ion Batteries
Facile Preparation of Three-Dimensional Cubic Mnse2 and Application in Aqueous Copper-Ion Batteries Open
View article: Facile Preparation of Three-Dimensional Cubic Mnse2 and Application in Aqueous Copper-Ion Batteries
Facile Preparation of Three-Dimensional Cubic Mnse2 and Application in Aqueous Copper-Ion Batteries Open
View article: Corrigendum to “Impact of different white matter hyperintensities patterns on cognition: A cross-sectional and longitudinal study”. [NeuroImage: Clinical. 34 (2022) 102978]
Corrigendum to “Impact of different white matter hyperintensities patterns on cognition: A cross-sectional and longitudinal study”. [NeuroImage: Clinical. 34 (2022) 102978] Open
View article: Maternal dietary inulin intake during late gestation and lactation ameliorates intestinal oxidative stress in piglets with the involvements of gut microbiota and bile acids metabolism
Maternal dietary inulin intake during late gestation and lactation ameliorates intestinal oxidative stress in piglets with the involvements of gut microbiota and bile acids metabolism Open
Maternal inulin intake has been shown to alleviate oxidative stress in piglets, but the role of bile acids (BAs) in this process remains unknown. This study aimed to investigate the roles of gut microbiota and BAs metabolism in the amelior…
View article: Efficiency of combination therapy versus monotherapy for the treatment of infections due to carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis
Efficiency of combination therapy versus monotherapy for the treatment of infections due to carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis Open
PROSPERO CRD42022331861.
View article: Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis Open
Ulcerative colitis (UC) is a debilitating inflammatory bowel disease characterized by intestinal inflammation, barrier dysfunction, and dysbiosis, with limited treatment options available. This study systematically investigates the therape…
View article: Facile Preparation of Three-Dimensional Cubic MnSe2/CNTs and Their Application in Aqueous Copper Ion Batteries
Facile Preparation of Three-Dimensional Cubic MnSe2/CNTs and Their Application in Aqueous Copper Ion Batteries Open
Transition metal sulfide compounds with high theoretical specific capacity and excellent electronic conductivity that can be used as cathode materials for secondary batteries attract great research interest in the field of electrochemical …