Yu Wang
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View article: Dietary antioxidants and CKM–depression comorbidity: a primary analysis with a secondary evaluation of all-cause mortality using six machine learning algorithms
Dietary antioxidants and CKM–depression comorbidity: a primary analysis with a secondary evaluation of all-cause mortality using six machine learning algorithms Open
Background We examined whether dietary antioxidant intake is associated with CKM–depression comorbidity (primary outcome) and all-cause mortality (secondary outcome) in US adults. Methods In an observational analysis of NHANES 2007–2010 wi…
View article: Healthy live birth after microsurgical enucleation of tripronuclear human zygote derived from ICSI: a case report
Healthy live birth after microsurgical enucleation of tripronuclear human zygote derived from ICSI: a case report Open
In the process of in vitro fertilization (IVF), zygote is considered as normally fertilized when there are two pronuclei (PN), one from sperm and the other from oocyte, and with two polar bodies (PBs). However, it is not uncommon to encoun…
View article: Interpretable artificial intelligence based on immunoregulation-related genes predicts prognosis and immunotherapy response in lung adenocarcinoma
Interpretable artificial intelligence based on immunoregulation-related genes predicts prognosis and immunotherapy response in lung adenocarcinoma Open
Introduction Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer, and its benefit from immune checkpoint inhibitors (ICIs) is controversial, especially for patients without driver gene mutations. The potenti…
View article: Plug-and-Play Self-Supervised Denoising for Pulmonary Perfusion MRI
Plug-and-Play Self-Supervised Denoising for Pulmonary Perfusion MRI Open
Pulmonary dynamic contrast-enhanced (DCE) MRI is clinically useful for assessing pulmonary perfusion, but its signal-to-noise ratio (SNR) is limited. A self-supervised learning network-based plug-and-play (PnP) denoising model was develope…
View article: SGPL1 Deficiency Get Involved in Imatinib Resistance via PI 3 K-Akt signaling pathway in gastrointestinal stromal tumor
SGPL1 Deficiency Get Involved in Imatinib Resistance via PI 3 K-Akt signaling pathway in gastrointestinal stromal tumor Open
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract. In recent years, secondary resistance to the first-line drug imatinib has become its bottleneck of targeted therapy due to the unclea…
View article: A Bi2O3-TiO2 Heterojunction for Triple-Modality Cancer Theranostics
A Bi2O3-TiO2 Heterojunction for Triple-Modality Cancer Theranostics Open
The formulations developed here have significant potential for future investigation and exploration in the treatment of cancer.
View article: Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain
Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain Open
Astrocytes are associated with varying brain size between rodents and primates. As a close evolutionary relative of primates, the tree shrew ( Tupaia belangeri) provides a valuable comparative model for investigating glial architecture. Ho…
View article: MBQ: Modality-Balanced Quantization for Large Vision-Language Models
MBQ: Modality-Balanced Quantization for Large Vision-Language Models Open
Vision-Language Models (VLMs) have enabled a variety of real-world applications. The large parameter size of VLMs brings large memory and computation overhead which poses significant challenges for deployment. Post-Training Quantization (P…
View article: Visual colorimetric immunosensor for sensitive detection of 4-Chlorophenoxyacetic based on TMB2+-mediated etching of Au NRs
Visual colorimetric immunosensor for sensitive detection of 4-Chlorophenoxyacetic based on TMB2+-mediated etching of Au NRs Open
4-Chlorophenoxyacetic acid (4-CPA), a synthetic plant regulator, has been banned due to its cumulative toxicity to humans. However, unqualified sampling remains common in the market. To address the poor sensitivity of 4-CPA antibodies repo…
View article: Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles
Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles Open
Hypoxia-induced alternative splicing (AS) regulates tumor progression and metastasis. Little is known about how such AS is controlled and whether higher-order genome and nuclear domain (ND) organizations dictate these processes. We observe…
View article: Vascular Endothelial Growth Factor a Promotes Chronic Itch via VEGFA-VEGFR2-PI3K-TRPV1 Axis in Allergic Contact Dermatitis
Vascular Endothelial Growth Factor a Promotes Chronic Itch via VEGFA-VEGFR2-PI3K-TRPV1 Axis in Allergic Contact Dermatitis Open
These findings suggest that VEGFA plays a crucial role in ACD-associated pruritus and may serve as a potential therapeutic target. However, further research is required to validate these findings and to explore additional molecular pathway…
View article: Genetic diversity analysis of Inner Mongolia cashmere goats (Erlangshan subtype) based on whole genome re-sequencing
Genetic diversity analysis of Inner Mongolia cashmere goats (Erlangshan subtype) based on whole genome re-sequencing Open
Background Inner Mongolia cashmere goat (IMCG), renowned for its superior cashmere quality, is a Chinese indigenous goat breed that has been developed through natural and artificial selection over a long period. However, recently, the gene…
View article: Potential analgesic effect of a novel cannabidiol nanocrystals powder for the treatment of neuropathic pain
Potential analgesic effect of a novel cannabidiol nanocrystals powder for the treatment of neuropathic pain Open
Background The current analgesics often prevent patients from getting effective treatment due to their adverse effects. Cannabidiol (CBD) is well tolerated, has few side effects and has been extensively investigated in analgesia. However, …
View article: Unexpected decrease in necrotizing enterocolitis morbidity during the COVID-19 pandemic-A single-centre retrospective study
Unexpected decrease in necrotizing enterocolitis morbidity during the COVID-19 pandemic-A single-centre retrospective study Open
Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on neonatal necrotizing enterocolitis (NEC) is not well characterised. This cross-sectional study evaluated the potential effects of pandemic-related measures on NEC…
View article: Effects of tislelizumab on health‐related quality of life in patients with recurrent or metastatic nasopharyngeal cancer
Effects of tislelizumab on health‐related quality of life in patients with recurrent or metastatic nasopharyngeal cancer Open
Background This study evaluated health‐related quality of life (HRQoL) in the RATIONALE‐309 (NCT03924986) intent‐to‐treat (ITT) population and in a subgroup of patients with liver metastases. Methods Patients were randomized 1:1 to tisleli…
View article: Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice
Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice Open
Background The dosage of ovalbumin (OVA) during the sensitization stage is considered a crucial factor in the development of airway hyperresponsiveness (AHR). However, the inconsistent dosages of sensitizing OVA used in current studies and…
View article: Licorice: comprehensive review of its chemical composition, pharmacodynamics, and medicinal value
Licorice: comprehensive review of its chemical composition, pharmacodynamics, and medicinal value Open
Licorice, a perennial herb of Leguminosa, is one of the oldest and most widely used herbal medicines worldwide. Its distinct sweet flavor and rich medicinal value make it an integral component of traditional Chinese medicine (TCM) formulat…
View article: The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation
The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation Open
Recent studies have revealed that tRNA modification is an important epigenetic mechanism involved in gene expression. Cytosolic thiouridylase (consisting of Ctu1 and Ctu2 subunit) are the enzyme complex which catalyze the thio-modification…
View article: Effective Treatment of Knee Osteoarthritis Using a Nano‐Enabled Drug Acupuncture Technology in Mice
Effective Treatment of Knee Osteoarthritis Using a Nano‐Enabled Drug Acupuncture Technology in Mice Open
A nano‐enabled drug delivery acupuncture technology ( nd ‐Acu) is developed that is based on traditional acupuncture needles where the stainless‐steel surface is designed to deliver various payload molecules. To create the nd ‐Acu platform…
View article: Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor
Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor Open
Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect. Sepsis-associated acute…
View article: Modified mRNA as a Treatment for Myocardial Infarction
Modified mRNA as a Treatment for Myocardial Infarction Open
Myocardial infarction (MI) is a severe disease with high mortality worldwide. However, regenerative approaches remain limited and with poor efficacy. The major difficulty during MI is the substantial loss of cardiomyocytes (CMs) with limit…
View article: Uncovering the pharmacological mechanisms of Zizhu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro
Uncovering the pharmacological mechanisms of Zizhu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro Open
Diabetic ulcer (DU) has been recognized as one of the most prevalent and serious complications of diabetes. However, the clinical efficacy of standard treatments for DU remains poor. Traditional Chinese medicine (TCM) shows a positive ther…
View article: Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet
Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet Open
Background Gut microbiota (GM) dysregulation, known as dysbiosis, has been proposed as a crucial driver of obesity associated with “Western” diet (WD) consumption. Gut dysbiosis is associated with increased gut permeability, inflammation, …