Shang‐Kwei Wang
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View article: Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava
Ubiquitin-Proteasome Modulating Dolabellanes and Secosteroids from Soft Coral Clavularia flava Open
We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral Clavularia flava, which potentiat…
View article: A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals
A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals Open
The ubiquitin-proteasome system (UPS) is a major proteolytic pathway that safeguards protein homeostasis. The main 26S proteasome consists of a 20S catalytic core proteasome and a 19S substrate recognition proteasome. UPS dysfunction under…
View article: Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata
Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata Open
A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberos…
View article: New Cytotoxic Terpenoids from Soft Corals Nephthea chabroli and Paralemnalia thyrsoides
New Cytotoxic Terpenoids from Soft Corals Nephthea chabroli and Paralemnalia thyrsoides Open
A novel cytotoxic diterpenoid, chabrolin A (1) (possessing an unprecedented terpenoid skeleton), as well as three new cytotoxic sesquiterpenoids, parathyrsoidins E–G (2–4), were isolated by cytotoxicity-guided fractionation from soft coral…