Mi Wang
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Clinical Study on the Combined Therapy of Sinew Acupuncture and Low‐Frequency Repetitive Transcranial Magnetic Stimulation for Hemiplegic Shoulder Pain Open
Objective To observe the clinical efficacy of combining sinew acupuncture with low‐frequency repetitive transcranial magnetic stimulation (rTMS) for treating hemiplegic shoulder pain. Methods A total of 90 patients with hemiplegic shoulder…
Nurses’ attitudes toward artificial intelligence: AI literacy as a predictor and the mediating effect of AI anxiety Open
Aims This study examines the demographic factors affecting nurses’ attitudes toward artificial intelligence (AI), AI literacy and AI anxiety. Explore the correlations among nurses’ AI literacy, AI anxiety and attitudes toward AI, and deter…
Clinical Characteristics Analysis of Bronchopneumonia in Children: A Retrospective Study Based on 418 Cases Open
Objective: To analyze the clinical characteristics of 418 children with bronchopneumonia and provide evidence for early clinical identification and intervention. Methods: A retrospective analysis was conducted on 418 children with bronchop…
Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cells Open
Endothelial dysfunction is a hallmark of various metabolic disorders and plays a pivotal role in the progression of cardiovascular diseases, including coronary microvascular dysfunction and myocardial ischemia. Lipid droplets (LDs) have em…
Dual-layer spectral detector CT-based scoring system for noninvasive TP53 expression assessment and adjuvant chemotherapy response prediction in gastric cancer: a multicenter cross-sectional study Open
Background: Noninvasive early prediction of TP53 is a key strategy for improving the prognosis of gastric cancer (GC) patients. To establish a novel, noninvasive and simple scoring system using dual-layer spectral detector computed tomogra…
Contribution of NLRP3-GSDMD axis to PDGF-BB-induced vascular smooth muscle cell phenotypic transition Open
This study reveals that the NLRP3-GSDMD axis drives PDGF-BB-induced dedifferentiation transition and inflammation of vascular smooth muscle cells (VSMCs), contributing to intimal hyperplasia. These findings identify NLRP3-GSDMD signaling a…
Machine learning model for predicting recurrence following intensity-modulated radiation therapy in nasopharyngeal carcinoma Open
The XGBoost model is a simple and accurate tool for predicting the prognosis of newly diagnosed NPC patients undergoing IMRT treatment, which may aid in preventing NPC recurrence and postoperative follow-up.
Nanchangmycin suppresses influenza A virus infection by blocking endosomal acidification Open
Influenza A viruses (IAVs) constitute a major threat to human and animal health. Currently, M2 ion-channel inhibitors, neuraminidase (NA) inhibitors, RNA polymerase inhibitors, and cap-dependent endonuclease inhibitors have been applied cl…
View article: Exploring the relationship between childhood maltreatment and cognitive bias in Chinese adults with major depressive disorder
Exploring the relationship between childhood maltreatment and cognitive bias in Chinese adults with major depressive disorder Open
This study aims to explore how different forms and cumulative experiences of childhood maltreatment (CM) relate to cognitive biases. A total of 121 participants diagnosed with major depressive disorder (MDD) and 120 healthy controls (HC) w…
Association between body fat percentage and urinary flow rate in US adults: analysis of the National Health and Nutrition Examination Survey 2011–2018 Open
This study examined the relationship between total body fat percentage (TBFP), trunk fat percentage (TFP), and urinary flow rate (UFR) using NHANES data (2011–2018) from 10 521 participants aged 18–59. Multivariable-adjusted regression mod…
Role of macrophages in vascular calcification: From the perspective of homeostasis Open
Vascular calcification (VC) is a crucial risk factor for the high morbidity and mortality associated with cardiovascular and cerebrovascular diseases. With the global population aging, the incidence of VC is escalating annually. However, d…
A Modified Novel Validated High-Throughput Hemagglutinin Inhibition Assay Using Recombinant Virus-like Particles and Human Red Blood Cells for the Objective Evaluation of Recombinant Hemagglutinin Nanoparticle Seasonal Influenza Vaccine Open
Currently available seasonal influenza vaccines confer variable protection due to antigenic changes resulting from the accumulation of diverse mutations. The analysis of new seasonal influenza vaccines is challenging in part due to the lim…
View article: Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder
Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder Open
BACKGROUND Symptoms of depression and comorbid anxiety are known risk factors for cognitive impairment in major depressive disorder (MDD). Understanding their relationships is crucial for developing targeted interventions to mitigate cogni…
A Modified Novel Validated High-Throughput Hemagglutinin Inhibition Assay Using Recombinant Virus-Like Particles and Human Red Blood Cells for the Objective Evaluation of Recombinant Hemagglutinin Nanoparticle Seasonal Influenza Vaccine Open
Currently available seasonal influenza vaccines confer variable protection due to antigenic changes resulting from accumulation of diverse mutations. Analysis of new seasonal influenza vaccines is challenging in part due to limitations of …
Effects of irradiation and stress on crack initiation behavior of 316SS flux thimble tubes in PWR environment Open
Irradiation assisted stress corrosion cracking (IASCC) behavior and irradiated microstructural features of cold-worked 316 stainless steel flux thimble tube specimens were investigated in 340 °C simulated PWR primary water. It covers three…
View article: Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9
Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9 Open
The bromodomain-containing protein BRD9 has emerged as an attractive therapeutic target. In the present study, we successfully identified a number of highly potent BRD9 degraders by using two different cereblon ligands developed in our lab…
A portent of catastrophic carbon dioxide embolism in laparoscopic hepatectomy: A case report Open
Introduction: Laparoscopic hepatectomy (LH) poses a high risk of carbon dioxide embolism due to extensive hepatic transection, long surgery duration, and dissection of the large hepatic veins or vena cava. Patient concerns: A 65-year-old m…
Validation of a Pseudovirus Neutralization Assay for Severe Acute Respiratory Syndrome Coronavirus 2: A High-Throughput Method for the Evaluation of Vaccine Immunogenicity Open
The evaluation of coronavirus disease 2019 (COVID-19) vaccine immunogenicity remains essential as the severe acute respiratory syncytial virus 2 (SARS-CoV-2) pandemic continues to evolve and as additional variants emerge. Neutralizing anti…
Inclusion Complexes of Ethanamizuril with β- and Hydroxypropyl-β-Cyclodextrin in Aqueous Solution and in Solid State: A Comparison Study Open
Ethanamizuril (EZL) is a new anticoccidial drug developed by our Shanghai Veterinary Research Institute. Since EZL is almost insoluble in water, we conducted a study to improve the solubility of EZL by forming inclusion complexes with β-cy…
p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer Open
Summary Prostate cancer is an exemplar of an enhancer-binding transcription factor-driven disease. The androgen receptor (AR) enhanceosome complex comprised of chromatin and epigenetic coregulators assembles at enhancer elements to drive d…
View article: Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer
Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer Open
CBP/p300 are critical transcriptional coactivators of the androgen receptor (AR) and are promising cancer therapeutic targets. Herein, we report the discovery of highly potent, selective, and orally bioavailable CBP/p300 degraders using th…
Factors affecting consumption of sugar-sweetened beverages in elementary school students in Nanjing Open
Surveys were conducted on sociodemographic characteristics, family, home- and school-related factors, and sugar-sweetened beverage (SSB) intake to identify factors associated with SSB consumption in children. In total, 2700 valid questionn…
View article: Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression
Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression Open
CBP/p300 proteins are key epigenetic regulators and promising targets for the treatment of castration-resistant prostate cancer and other types of human cancers. Herein, we report the discovery and characterization of CBPD-268 as an except…