Xin Wang
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View article: SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer
SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer Open
Background Serum amyloid A (SAA), an acute-phase pro-inflammatory protein, is overexpressed in several cancers and is involved in shaping pro-tumor responses. We have previously reported that lung cancer stem cells secrete SAA, which contr…
View article: Study on the Influence Mechanism of the Rhizosphere Soil Microbial Community and Physicochemical Factors on the Occurrence of Pepper Phytophthora Blight
Study on the Influence Mechanism of the Rhizosphere Soil Microbial Community and Physicochemical Factors on the Occurrence of Pepper Phytophthora Blight Open
In order to clarify the changes and correlations among microbial community structure and soil environmental factors in the rhizosphere soil of peppers under healthy and diseased conditions, Illumina MiSeq technology was used to perform hig…
Advances in Strategies for In Vivo Directed Evolution of Targeted Functional Genes Open
Enzymes are indispensable in fields such as biotechnology, medicine, and industrial manufacturing due to their high catalytic specificity and efficiency under mild conditions. However, their natural versions often suffer from limitations, …
ETS-related gene as a key factor in curcumin inhibition of glucose metabolism in prostate cancer cells: an in vitro experimental study Open
Background: Curcumin, the main yellow pigment in turmeric, is a potent anticancer agent. However, its effect on the viability of human prostate cancer (PCa) cells and underlying mechanisms remain unclear. This study aimed to determine the …
Effects of omega-3 fatty acids on chronic pain: a systematic review and meta-analysis Open
Background Chronic pain afflicts approximately 20% of the global adult population and is frequently undertreated, with available pharmacologic options often associated with significant long-term adverse effects. Although omega-3 fatty acid…
Dye sensitized NaErF4: Ce3+, Yb3+ nanodisks achieve efficient near-infrared IIb region luminescence Open
Luminescence in the second near-infrared window (NIR-IIb, 1500–1700 nm) has garnered significant attention in bioimaging due to its advantages of deep tissue penetration and low autofluorescence. However, luminescent materials in this spec…
Smoking elevating osteoarthritis risk: Insights from genetics, blood DNA methylations and proteome profiles Open
The relationship between smoking and osteoarthritis (OA) incidence remains unclear. This study aimed to explore the association of smoking behaviors and OA morbidity in the UK Biobank and further investigate the mediating role of DNA methy…
Gut Microbiome of Two Rodent Species (Niviventer confucianus and Apodemus agrarius) from Two Regions Exhibit Different Structures and Assembly Mechanisms Open
The structure and assembly mechanism of wild animal gut microbiota represent persistent research hotspots. Among, the impact of geographic factors on the bacterial co-occurrence network characteristics and assembly mechanism of the gut mic…
A Cascade‐Targeting System Delivering Polyphenol Into the Mitochondria of M1 Macrophages for Inflammatory Bowel Disease Therapy Open
Precise intervention targeting the mitochondria of macrophages represents a promising therapeutic strategy to address the challenges of limited clinical efficacy and high risk of adverse reactions in current pharmacological treatments for …
Microglial Deletion of <i>Hrh4</i> Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau Open
Amyloid‐beta (Aβ) and hyperphosphorylated tau (p‐tau) aggregation are hallmark pathogenic events in Alzheimer's disease (AD). Microglial clearance of these toxic aggregates is essential, yet the underlying mechanisms remain poorly understo…
View article: Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients
Circulating tumor DNA refines consolidation immunotherapy for limited-stage small cell lung cancer patients Open
Despite the lack of predictive biomarkers and a prognostic stratification strategy, immune checkpoint inhibitor (ICI) has shown promise in improving outcomes for patients with limited-stage small cell lung cancer (LS-SCLC). We evaluated th…
View article: Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma
Genome-wide CRISPR screen identifies splicing factor SF3B4 in driving hepatocellular carcinoma Open
Although genome sequencings have recognized many cancer-associated genes in hepatocellular carcinoma (HCC), distinguishing their functional effect remains challenging. Leveraging on a genome-wide CRISPR knockout (KO) screening, we uncovere…
View article: Hypothalamic subunit volumes in schizophrenia with comorbidity of metabolic syndrome
Hypothalamic subunit volumes in schizophrenia with comorbidity of metabolic syndrome Open
Schizophrenia and metabolic syndrome (MS) are common conditions that frequently co-occur, yet the neurobiological mechanisms underlying their comorbidity remain unclear. This study aimed to investigate whether hypothalamic structural alter…
View article: Development and validation of nomograms for predicting grade ≥3 diarrhea and neutropenia after abemaciclib combined with endocrine therapy for breast cancer: a multicenter retrospective real-world study
Development and validation of nomograms for predicting grade ≥3 diarrhea and neutropenia after abemaciclib combined with endocrine therapy for breast cancer: a multicenter retrospective real-world study Open
Background This study aimed to investigate the risk factors associated with grade ≥3 diarrhea and neutropenia, which are the most common adverse events (AEs) leading to discontinuation and dose reduction in patients with hormone receptor-p…
FC-YOLO: a fast inference backbone and lightweight attention mechanism-enhanced YOLO for detecting gastric adenocarcinoma in pathological image Open
Background Gastric adenocarcinoma (GAC) is a leading cause of cancer-related mortality, but its histopathological diagnosis is challenged by image complexity and a shortage of pathologists. While deep learning models show promise, many are…
Exploring the survival benefits of surgical treatment for pancreatic adenocarcinoma using the DeepSurv neural network model Open
To develop a DeepSurv model for predicting survival in pancreatic adenocarcinoma patients, evaluating the benefit of surgical versus non-surgical treatment across different stages, including stage IV subcategories. Clinical data were extra…
View article: A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression Open
Metabolic reprogramming, notably alterations in the tricarboxylic acid (TCA) cycle, has emerged as a hallmark of cancer that supports tumor growth and metastasis. Despite the TCA cycle being a classical central metabolic pathway, further e…
Calcium-sensing receptor AcCaS regulates chloroplast immunity in kiwifruit by competitively binding with Ca2+ or the <i>Psa</i> effector Open
Activating chloroplast immunity to enhance host resistance offers a novel and sustainable approach for the effective control of kiwifruit bacterial canker. Chloroplasts serve as a central hub for ROS, SA, and Ca2+ signaling. As a chloropla…
View article: Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by <i>UGT1A1</i> status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial
Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by <i>UGT1A1</i> status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial Open
Background The optimal regimen and chemotherapy intensity are still under investigation for neoadjuvant treatment of locally advanced rectal cancer (LARC). The CinClare trial has demonstrated improved pathologic complete response (pCR) wit…
View article: miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene
miR-34c regulates the proliferation, apoptosis, and testosterone synthesis of bovine leydig cells by targeted ATG5 gene Open
The reproductive potential of bull represents a key economic trait in modern cattle husbandry. The primary determinant of bull reproductive capacity is the proper development of the testes, which is essential for the production of spermato…
View article: Function of <i>SP1</i> in tumors and focused treatment approaches for immune evasion (Review)
Function of <i>SP1</i> in tumors and focused treatment approaches for immune evasion (Review) Open
Immune escape is a phenomenon in which tumor cells or infections evade detection and clearance by the host immune system in various ways. During an antitumor immune response, cells increase the concentration of pentameric stalk, which enha…
Integrated PTS fire evacuation path planning algorithm Open
Fire evacuation in large-scale buildings presents significant challenges, including prolonged evacuation times, exit congestion, and frequent communication breakdowns. To address these issues, this study proposes a novel hybrid fire evacua…