Yajing Wang
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View article: Association of Central Serous Chorioretinopathy With Endogenous or Exogenous Corticosteroids: A Report of 2 Cases
Association of Central Serous Chorioretinopathy With Endogenous or Exogenous Corticosteroids: A Report of 2 Cases Open
This study aimed to elucidate the potential relationship between central serous chorioretinopathy (CSC) and both endogenous hypercortisolism and the administration of exogenous corticosteroids. Case 1 involved a 39-year-old female patient …
View article: Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy
Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy Open
View article: Serum Isthmin-1 levels are positively correlated with macrovascular complications in type 2 diabetic patients
Serum Isthmin-1 levels are positively correlated with macrovascular complications in type 2 diabetic patients Open
Objective Isthmin-1 (ISM-1), a novel adipokine, has dual effects of increasing fat and glucose uptake while inhibiting hepatic fat synthesis. However, little literature has been found dealing with ISM-1 levels in type 2 diabetes patients w…
View article: Circulating prosaposin and ependymin-related protein 1 levels are correlated with insulin resistance in type 2 diabetic patients
Circulating prosaposin and ependymin-related protein 1 levels are correlated with insulin resistance in type 2 diabetic patients Open
Objective Skeletal muscle and adipose tissues secrete myokines and adipokines to regulate energy metabolism. Experimental evidence indicates that prosaposin (PSAP) and ependymin-related protein 1 (EPDR1) are involved in the regulation of t…
View article: Long-term white matter changes in patients who develop severe depression after multiple COVID-19 infections: a 3–6-month study
Long-term white matter changes in patients who develop severe depression after multiple COVID-19 infections: a 3–6-month study Open
The present study revealed impairments in the WM integrity of patients who developed severe depression within 3-6 months of repeated COVID-19 infections. The findings revealed the mechanism of COVID-19-related depression and underscored th…
View article: Multi-Level Gray Evaluation Method for Assessing Health Risks in Indoor Environments
Multi-Level Gray Evaluation Method for Assessing Health Risks in Indoor Environments Open
Recently, health risk assessment and early warning systems for high-temperature events have become critical concerns. However, current high-temperature warning systems primarily focus on temperature alone, which fails to accurately reflect…
View article: <scp>STAT3</scp> Inhibition Prevents Adaptive Resistance and Augments <scp>NK</scp> Cell Cytotoxicity to <scp>KRAS<sup>G12C</sup></scp> Inhibitors in Nonsmall Cell Lung Cancer
<span>STAT3</span> Inhibition Prevents Adaptive Resistance and Augments <span>NK</span> Cell Cytotoxicity to <span>KRAS<sup>G12C</sup></span> Inhibitors in Nonsmall Cell Lung Cancer Open
KRAS G12C inhibitors exhibit conspicuous clinical response in KRAS G12C ‐mutant lung cancer, yet adaptive resistance, the rapid onset of intrinsic resistance, dampens their therapeutic success. Rational combination strategies could tackle …
View article: Accurate and robust segmentation of cerebral distal small arteries by DVNet with dual contextual path and vascular attention enhancement
Accurate and robust segmentation of cerebral distal small arteries by DVNet with dual contextual path and vascular attention enhancement Open
Our approach demonstrates that accurate and robust cerebrovascular segmentation is achievable on MRA using DVNet with DCP and VAEM, especially in small distal vessels.
View article: Narcolepsy in early childhood: a case report and a Mini review
Narcolepsy in early childhood: a case report and a Mini review Open
Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10–30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is part…
View article: Down-regulation of HSPB1 and MGST1 promote ferroptosis and impact immune infiltration in diabetic cardiomyopathy
Down-regulation of HSPB1 and MGST1 promote ferroptosis and impact immune infiltration in diabetic cardiomyopathy Open
View article: Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential
Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential Open
The field of cancer neuroscience has rapidly evolved, shedding light on the complex interplay between the nervous system and cancer, with a particular focus on the relationship between the central nervous system (CNS) and gliomas. Recent a…
View article: Innovative Categorization and Operative Management of Auditory Ossicle Disruption Following Trauma: Therapeutic Efficacy and Interventional Paradigms
Innovative Categorization and Operative Management of Auditory Ossicle Disruption Following Trauma: Therapeutic Efficacy and Interventional Paradigms Open
Currently, there is no consensus on the treatment protocol for ossicular chain trauma. This study aims to investigate the classification and treatment strategies for traumatic ossicular chain dislocation. We retrospectively analyzed 15 pat…
View article: Large vessel occlusion mediated fluid attenuated inversion recovery signal intensity ratio is associated with stroke within 4.5 h
Large vessel occlusion mediated fluid attenuated inversion recovery signal intensity ratio is associated with stroke within 4.5 h Open
Introduction The primary objective was to investigate the value of the fluid attenuated inversion recovery (FLAIR) signal intensity ratio (SIR) in identifying stroke within 4.5 h. The secondary objective was to ascertain whether large vess…
View article: Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons
Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons Open
These findings collectively suggest that JuA improves depressive-like behavior in CUMS rats by modulating calcium homeostasis and synaptic structural plasticity in immature neurons through the Shh signaling pathway.
View article: Automatic substantia nigra segmentation with Swin-Unet in susceptibility- and T2-weighted imaging: application to Parkinson disease diagnosis
Automatic substantia nigra segmentation with Swin-Unet in susceptibility- and T2-weighted imaging: application to Parkinson disease diagnosis Open
BACKGROUND: Accurately distinguishing between Parkinson disease (PD) and healthy controls (HCs) through reliable imaging method is crucial for appropriate therapeutic intervention. However, PD diagnosis is hindered by the subjective nature…
View article: Web-Based Dynamic Nomogram for Predicting Risk of Mortality in Heart Failure with Mildly Reduced Ejection Fraction
Web-Based Dynamic Nomogram for Predicting Risk of Mortality in Heart Failure with Mildly Reduced Ejection Fraction Open
In this study, the dynamic APSELNH nomogram developed serves as an accessible, functional, and effective clinical decision support calculator, offering accurate prognostic assessment for patients with HFmrEF.
View article: Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology
Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology Open
In hypertrophic scars, the differentiation and migration of fibroblasts are influenced by the extracellular matrix microenvironment, which includes factors such as stiffness, restraint, and tensile force. These mechanical stresses incite a…
View article: Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma
Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma Open
Hepatic artery infusion chemotherapy (HAIC) has good clinical efficacy in the treatment of advanced hepatocellular carcinoma (HCC); however, its efficacy varies. This review summarized the ability of various markers to predict the efficacy…
View article: Causal Association of Social Determinants of Health and Dynamic Impact on Mortality in Patients with Chronic Heart Failure
Causal Association of Social Determinants of Health and Dynamic Impact on Mortality in Patients with Chronic Heart Failure Open
Purpose The causality between social determinants of health (SDoH) and mortality in patients with chronic heart failure (CHF) is uncertain. Herein, we assessed the causality using inverse probability weighting (IPW) of marginal structural …
View article: Diffusion-/perfusion-weighted imaging fusion to automatically identify stroke within 4.5 h
Diffusion-/perfusion-weighted imaging fusion to automatically identify stroke within 4.5 h Open
Objectives We aimed to develop machine learning (ML) models based on diffusion- and perfusion-weighted imaging fusion (DP fusion) for identifying stroke within 4.5 h, to compare them with DWI- and/or PWI-based ML models, and to construct a…
View article: Circadian Rhythms in Cardiovascular Metabolism
Circadian Rhythms in Cardiovascular Metabolism Open
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters…
View article: ATP protects anti-PD-1/radiation-induced cardiac dysfunction by inhibiting anti-PD-1 exacerbated cardiomyocyte apoptosis, and improving autophagic flux
ATP protects anti-PD-1/radiation-induced cardiac dysfunction by inhibiting anti-PD-1 exacerbated cardiomyocyte apoptosis, and improving autophagic flux Open
View article: Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice
Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice Open
View article: Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury
Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury Open
Background. High morbidity of nonspecific low back pain (NLBP) and large consumption of medical resources caused by it have become a heavy social burden. There are many factors inducing NLBP, among which the damage and atrophy of multifidu…
View article: COVID-19 and cardiovascular complications: updates of emergency medicine
COVID-19 and cardiovascular complications: updates of emergency medicine Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV-2 variants, has become a global pandemic resulting in significant morbidity and mortality. Severe cases of COVID-19 ar…
View article: A new tetracyclic triterpenoid from endophytic fungus Fusarium sporotrichioides
A new tetracyclic triterpenoid from endophytic fungus Fusarium sporotrichioides Open
View article: Acacetin-loaded microemulsion for transdermal delivery: preparation, optimization and evaluation
Acacetin-loaded microemulsion for transdermal delivery: preparation, optimization and evaluation Open
The formulation of ME combined with the penetration enhancer can effectively improve the solubility and percutaneous absorption efficiency of acacetin, providing a new option for the non-invasive delivery of acacetin.
View article: Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice Open
Genetically modified (GM) mice are essential tools in biomedical research. Traditional methods for generating GM mice are expensive and require specialized personnel and equipment. The use of clustered regularly interspaced short palindrom…
View article: [Reliability and validity of the Chinese version of URICA-Voice scale].
[Reliability and validity of the Chinese version of URICA-Voice scale]. Open
Objective:To translate the University of Rhode Island Change Assessment of voice scale（URICA-Voice） into Chinese and test its reliability and validity. Methods:The URICA-Voice scale was converted into Chinese by literal trans…
View article: Detection of intermediate- and high-risk prostate cancer with biparametric magnetic resonance imaging: a systematic review and meta-analysis
Detection of intermediate- and high-risk prostate cancer with biparametric magnetic resonance imaging: a systematic review and meta-analysis Open
bpMRI exhibited a high negative predictive value and accuracy in the diagnosis of IHPC, and may be valuable for detecting PCa with poor prognosis. However, the bpMRI protocol needs to be standardized further to improve its wider applicabil…