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View article: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa
Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa Open
To the best of our knowledge, this work demonstrates for the first time that a gene augmentation approach can restore vision and preserves photoreceptors in an animal model of CNGA1-RP. These findings pave the way for future development of…
View article: Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial
Efficacy and Safety of Efdamrofusp Alfa with Personalized Dosing Intervals in Neovascular Age-Related Macular Degeneration: A Phase II Trial Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response
IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response Open
Background Despite initial success with FLT3 inhibitors (FLT3is), outcomes for FLT3-ITD acute myeloid leukemia (AML) patients remain unsatisfactory, underscoring the need for more effective treatment options. Epigenetic modifications, such…
View article: Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia Open
View article: Effects of analgesic delivery on pelvic floor function of primiparous women
Effects of analgesic delivery on pelvic floor function of primiparous women Open
This was an original article, and the objective of this study was to clarify the short-term effects of analgesic delivery on the pelvic floor function of primiparous women. Three hundred primiparas who delivered vaginally in The Affiliated…
View article: Advances in the localization of pulmonary nodules: a comprehensive review
Advances in the localization of pulmonary nodules: a comprehensive review Open
In recent years, with the widespread use of chest CT, the detection rate of pulmonary nodules has significantly increased (Abtin and Brown, J Clin Oncol 31:1002-8, 2013). Video-assisted thoracoscopic surgery (VATS) is the most commonly use…
View article: Genomic characterization of Bacillus cereus isolated from food poisoning cases revealed the mechanism of toxin production
Genomic characterization of Bacillus cereus isolated from food poisoning cases revealed the mechanism of toxin production Open
Introduction Bacillus cereus is a ubiquitous opportunistic human pathogen that causes food intoxications worldwide. However, the genomic characteristics and pathogenic mechanisms of B. cereus are still unclear. Methods Here, we isolated an…
View article: Macrophage<i>Sult2b1</i>promotes pathological neovascularization in age-related macular degeneration
Macrophage<i>Sult2b1</i>promotes pathological neovascularization in age-related macular degeneration Open
Disordered immune responses and cholesterol metabolism have been implicated in age-related macular degeneration (AMD), the leading cause of blindness in elderly individuals. SULT2B1, the key enzyme of sterol sulfonation, plays important ro…
View article: Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition Open
View article: Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression Open
View article: Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration
Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration Open
Introduction: The aims of this study were to investigate the molecular alterations of cuproptosis-related genes and to construct the cuproptosis-related circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in neovascular age…
View article: Clinical Efficacy and Safety of Acupuncture Rehabilitation for Post-stroke Depression: A Systematic Review and Meta-analysis
Clinical Efficacy and Safety of Acupuncture Rehabilitation for Post-stroke Depression: A Systematic Review and Meta-analysis Open
Objective: The most important and common psychiatric disorders after stroke include post-stroke depression, which can lead to a variety of negative health outcomes. This study was calculated to estimate the security and effectiveness of ac…
View article: Large-scale genome investigations reveal insights into domestication of cultivated mushrooms
Large-scale genome investigations reveal insights into domestication of cultivated mushrooms Open
Domestication and cultivation of edible and medicinal mushrooms are ongoing ~1,400-year old evolutionary experiments. There are roughly 55 commercially cultivated mushrooms worldwide; however, genomes for many species are lacking, as is ou…
View article: HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity Open
Herpes simplex virus type 1 (HSV-1), an α subgroup member of the human herpesvirus family, infects cells via the binding of its various envelope glycoproteins to cellular membrane receptors, one of which is herpes virus entry mediator (HVE…
View article: 93P Noncancer-specific mortality in patients with stage IA1 NSCLC after surgical resection: The role of comorbidities in prognosis
93P Noncancer-specific mortality in patients with stage IA1 NSCLC after surgical resection: The role of comorbidities in prognosis Open
View article: A novel and efficient murine model of Bietti crystalline dystrophy
A novel and efficient murine model of Bietti crystalline dystrophy Open
Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and development mechanism of it remain unclear. Given the defects in previous mouse models of BCD…
View article: Identification of a novel RPGR mutation associated with X-linked cone-rod dystrophy in a Chinese family
Identification of a novel RPGR mutation associated with X-linked cone-rod dystrophy in a Chinese family Open
Background Cone-rod dystrophy (CORD) is a group of inherited retinal dystrophies, characterized by decreased visual acuity, color vision defects, photophobia, and decreased sensitivity in the central visual field. Our study has identified …
View article: Interventional bronchoscopic treatment of lung cancer
Interventional bronchoscopic treatment of lung cancer Open
View article: Dynamic Changes in Neutrophil-to-Lymphocyte Ratio are Associated with Survival and Liver Toxicity Following Stereotactic Body Radiotherapy for Hepatocellular Carcinoma
Dynamic Changes in Neutrophil-to-Lymphocyte Ratio are Associated with Survival and Liver Toxicity Following Stereotactic Body Radiotherapy for Hepatocellular Carcinoma Open
Chih-Weim Hsiang,1 Wen-Yen Huang,2,3 Jen-Fu Yang,2 Po-Chien Shen,2 Yang-Hong Dai,2 Ying-Fu Wang,2 Chun-Shu Lin,2 Wei-Chou Chang,1 Cheng-Hsiang Lo2 1Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Tai…
View article: [Experience of clinical diagnosis and treatment in 42 children with pen-cap foreign body in trachea and bronchus].
[Experience of clinical diagnosis and treatment in 42 children with pen-cap foreign body in trachea and bronchus]. Open
View article: Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies
Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies Open
View article: Migration of ingested sharp foreign body into the bronchus: a case report and review of the literature
Migration of ingested sharp foreign body into the bronchus: a case report and review of the literature Open
Background Foreign body ingestion is a common emergence in gastroenterology. Foreign bodies are most likely to be embedded in the esophagus. The sharp ones may penetrate the esophageal wall and lead to serious complications. Case presentat…
View article: [Clinical analysis of severe cases of bronchial foreign body with mediastinal and subcutaneous emphysema in children].
[Clinical analysis of severe cases of bronchial foreign body with mediastinal and subcutaneous emphysema in children]. Open
View article: Mushroom Poisoning Outbreaks — China, 2010–2020
Mushroom Poisoning Outbreaks — China, 2010–2020 Open
Conclusions: Mushroom poisoning is a food safety issue of higher concern in China. Targeted health education is essential to reduce mushroom poisoning, especially in southwest China. Citizens are advised to not collect or eat wild m…
View article: Segmental Duplication as Potential Biomarkers for Non-Invasive Prenatal Testing of Aneuploidies
Segmental Duplication as Potential Biomarkers for Non-Invasive Prenatal Testing of Aneuploidies Open
View article: Acupuncture for osteoporosis: study protocol for a randomized controlled trial
Acupuncture for osteoporosis: study protocol for a randomized controlled trial Open
Background: The rapid increase in the prevalence of osteoporosis and the rate of fractures after osteoporosis indicates that osteoporosis has become a serious global public health problem. A recent meta-analysis showed that oral alendronat…
View article: Overall adjustment acupuncture for postmenopausal osteoporosis (PMOP): A study protocol for a randomized sham-controlled trial
Overall adjustment acupuncture for postmenopausal osteoporosis (PMOP): A study protocol for a randomized sham-controlled trial Open
Background: Osteoporosis is becoming more prevalent in aging societies worldwide, and the economic burden attributable to osteoporotic fractures is substantial. The medications presently available to treat osteoporosis have side effects, a…
View article: Correction
Correction Open
View article: Acute kidney injury in cancer patients: A nationwide survey in China
Acute kidney injury in cancer patients: A nationwide survey in China Open
View article: The difference in prognosis of stage II and III colorectal cancer based on preoperative serum tumor markers
The difference in prognosis of stage II and III colorectal cancer based on preoperative serum tumor markers Open
Background: Preoperative serum tumor markers have been widely used to predict prognosis in stage II and III colorectal cancer (CRC). However, few previous studies addressed the effect of increased preoperative numbers of tumor marke…