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View article: Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium
Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium Open
Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about ho…
View article: Discovery of potent and selective peroxiredoxin 2 agonist natural products and derivatives against myocardial ischemia-reperfusion injury
Discovery of potent and selective peroxiredoxin 2 agonist natural products and derivatives against myocardial ischemia-reperfusion injury Open
View article: Genome-Wide Pleiotropy Analysis Identifies Shared and Opposing Pathways Influencing Coronary Artery Disease and Cancer
Genome-Wide Pleiotropy Analysis Identifies Shared and Opposing Pathways Influencing Coronary Artery Disease and Cancer Open
BACKGROUND: Coronary artery disease (CAD) and cancer are 2 leading global causes of mortality, with shared modifiable risk factors, yet the genetic and molecular mechanisms underlying their comorbidity remain poorly understood. METHODS: We…
View article: Longitudinal Comorbidity Patterns Prior to Pulmonary Hypertension Diagnosis
Longitudinal Comorbidity Patterns Prior to Pulmonary Hypertension Diagnosis Open
BACKGROUND Pulmonary hypertension (PH) is a progressive and life-threatening condition that is often diagnosed late due to nonspecific symptoms shared with other cardiopulmonary diseases. The temporal relationship between comorbidities and…
View article: Comparative study of coronary artery disease prediction: conventional QRISK3 versus enhanced machine learning models combined with particle swarm optimisation algorithm
Comparative study of coronary artery disease prediction: conventional QRISK3 versus enhanced machine learning models combined with particle swarm optimisation algorithm Open
Background Coronary artery disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CAD. QRISK3 is known to overestimate future CAD risk in some p…
View article: Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis
Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is thought to be caused by interaction between genetic and environmental factors leading to motor neuron (MN) degeneration. Physical exercise has been linked to ALS but controversy remains. A key questio…
View article: Clustering Patients with Pulmonary Hypertension Using the Plasma Proteome
Clustering Patients with Pulmonary Hypertension Using the Plasma Proteome Open
Background: Patients with pulmonary hypertension are classified according to clinical criteria to inform treatment decisions. Knowledge of the molecular drivers of pulmonary hypertension might better inform treatment choice. Obje…
View article: Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention
Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention Open
Background The role of lipid-perturbing medications in cancer risk is unclear. Methods We employed cis-Mendelian randomization and colocalization to evaluate the role of 5 lipid-perturbing drug targets (ANGPTL3, ANGPTL4, APOC3, CETP, and P…
View article: Machine Learning Framework for Longitudinal Functional Decline and Time-to-Event Prediction
Machine Learning Framework for Longitudinal Functional Decline and Time-to-Event Prediction Open
Harnessing longitudinal data for time to event analysis can provide valuable insights into disease progression and help plan clinical interventions for individual patients, with the goal of improving clinical outcomes and quality of life. …
View article: Longitudinal prediction of DNA methylation to forecast epigenetic outcomes
Longitudinal prediction of DNA methylation to forecast epigenetic outcomes Open
Wellcome Trust, Singapore National Research Foundation (NRF), Singapore National Medical Research Council (NMRC), Agency for Science, Technology and Research (A∗STAR), UK Academy of Medical Sciences and the UK Engineering and Physical Scie…
View article: Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension
Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension Open
BACKGROUND: Patients with pulmonary hypertension (PH) are classified based on disease pathogenesis and hemodynamic drivers. Classification informs treatment. The heart failure biomarker NT-proBNP (N-terminal pro-B-type natriuretic peptide)…
View article: Blood Pressure Variability in Older Patients with Chronic Kidney Disease
Blood Pressure Variability in Older Patients with Chronic Kidney Disease Open
Background: An increased blood pressure variability (BPV) is associated with a high risk of cardiovascular events in the general population. This concept was scarcely tested in patients with chronic kidney disease (CKD). We investigated th…
View article: Remote monitoring of physical activity captured by the MyHeart Counts app identifies pulmonary arterial hypertension
Remote monitoring of physical activity captured by the MyHeart Counts app identifies pulmonary arterial hypertension Open
Introduction The diagnosis of Pulmonary arterial hypertension (PAH) is often delayed. Wearable devices and smartphone applications have potential to remotely monitor patients and as access to technology increases, potentially identify pati…
View article: Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm
Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm Open
Offspring health outcomes are often linked with epigenetic alterations triggered by maternal nutrition and intrauterine environment. Strong experimental data also link paternal preconception nutrition with pathophysiology in the offspring,…
View article: Unleashing potential: evaluating the effectiveness of the BOPPPS teaching strategy in Chinese urology education
Unleashing potential: evaluating the effectiveness of the BOPPPS teaching strategy in Chinese urology education Open
Introduction The BOPPPS teaching strategy has gained popularity in medical education in China as a more effective and practical pedagogy. However, its impact on knowledge acquisition and clinical skills in urology education has not been co…
View article: <i>Notes from the Field</i>: Seroprevalence of Highly Pathogenic Avian Influenza A(H5) Virus Infections Among Bovine Veterinary Practitioners — United States, September 2024
<i>Notes from the Field</i>: Seroprevalence of Highly Pathogenic Avian Influenza A(H5) Virus Infections Among Bovine Veterinary Practitioners — United States, September 2024 Open
View article: Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination
Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination Open
Singapore National Research Foundation and Agency for Science, Technology and Research.
View article: Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research Open
Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamin…
View article: Correction: Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes
Correction: Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes Open
View article: Even moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age
Even moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age Open
In Asian women of reproductive age, moderate liver fat accumulation below the conventional fatty liver cutoff was not metabolically benign and was linked to gestational dysglycemia. The newly derived cutoff can aid in screening individuals…
View article: Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes
Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes Open
View article: Multi-trait association analysis reveals shared genetic loci between Alzheimer’s disease and cardiovascular traits
Multi-trait association analysis reveals shared genetic loci between Alzheimer’s disease and cardiovascular traits Open
Several cardiovascular traits and diseases co-occur with Alzheimer’s disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic …
View article: Ex-vivo models of post-surgical residual disease in human glioblastoma
Ex-vivo models of post-surgical residual disease in human glioblastoma Open
Background Glioblastoma is a highly infiltrative, currently incurable brain cancer. To date, translation of novel therapies for glioblastoma from the laboratory into clinical trials has relied heavily on in vitro cell culture and murine (s…
View article: Multi-output prediction of dose–response curves enables drug repositioning and biomarker discovery
Multi-output prediction of dose–response curves enables drug repositioning and biomarker discovery Open
View article: Discovery of Hypoxanthine and Inosine as Robust Biomarkers for Predicting the Preanalytical Quality of Human Plasma and Serum for Metabolomics
Discovery of Hypoxanthine and Inosine as Robust Biomarkers for Predicting the Preanalytical Quality of Human Plasma and Serum for Metabolomics Open
In cold human blood, the anomalous dynamics of adenosine triphosphate (ATP) result in the progressive accumulation of adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosine monophosphate (IMP), inosine, and hypoxanthine. While…
View article: Cluster of Influenza A(H5) Cases Associated with Poultry Exposure at Two Facilities — Colorado, July 2024
Cluster of Influenza A(H5) Cases Associated with Poultry Exposure at Two Facilities — Colorado, July 2024 Open
Persons who work in close contact with dairy cattle and poultry that are infected with highly pathogenic avian influenza (HPAI) A(H5N1) virus are at increased risk for infection. In July 2024, the Colorado Department of Public Health & Env…
View article: Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes
Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes Open
Background Body mass index (BMI) trajectories of children have been used to assess their growth with respect to their peers, as well as to anticipate future obesity and disease risk. While retrospective modelling of childhood BMI trajector…
View article: Longitudinal prediction of DNA methylation to forecast epigenetic outcomes
Longitudinal prediction of DNA methylation to forecast epigenetic outcomes Open
Background Interrogating the biological changes at early stages of life requires longitudinal profiling of molecules, but biosamples may not always be available. Results We introduce a probabilistic and longitudinal machine learning framew…
View article: Measles Outbreak Associated with a Migrant Shelter — Chicago, Illinois, February–May 2024
Measles Outbreak Associated with a Migrant Shelter — Chicago, Illinois, February–May 2024 Open
Measles, a highly contagious respiratory virus with the potential to cause severe complications, hospitalization, and death, was declared eliminated from the United States in 2000; however, with ongoing global transmission, infections in t…
View article: DeepARV: ensemble deep learning to predict drug-drug interaction of clinical relevance with antiretroviral therapy
DeepARV: ensemble deep learning to predict drug-drug interaction of clinical relevance with antiretroviral therapy Open
Drug-drug interaction (DDI) may result in clinical toxicity or treatment failure of antiretroviral therapy (ARV) or comedications. Despite the high number of possible drug combinations, only a limited number of clinical DDI studies are con…