Zonghua Wang
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View article: Global trends in carbapenem-resistant gram-negative bacteria research (2020–2025): a bibliometric analysis and systematic review
Global trends in carbapenem-resistant gram-negative bacteria research (2020–2025): a bibliometric analysis and systematic review Open
Background Carbapenem-resistant Gram-negative bacteria (CRGNB) pose a severe global health threat, yet comprehensive bibliometric analyses in this field remain limited. This systematic review employs a bibliometric methodology to identify …
View article: Fungal Mst3-proteins are involved in fungal innate immunity needed for the recognition of bacteria surrounding the hyphae, as well as for plant pathogenicity
Fungal Mst3-proteins are involved in fungal innate immunity needed for the recognition of bacteria surrounding the hyphae, as well as for plant pathogenicity Open
Fungal innate immunity resembles mammalian innate immunity. It does not employ toll-like receptors (TLRs), but should employ endocytosis of non-fungal molecular patterns recognized by nuclear-localizing receptors (NLR). Downstream, both ty…
View article: Research on the Pathogenic Mechanism of Effector FvCfem7 in Fusarium verticillioides
Research on the Pathogenic Mechanism of Effector FvCfem7 in Fusarium verticillioides Open
Fusarium verticillioides, a hemibiotrophic pathogen, infects a range of important crops and contaminates grains with fumonisin B1 (FB1) toxins, posing serious threats to yield, quality, and food safety. Secreted proteins containing Common …
View article: Antifungal mechanisms of oregano essential oil against Aspergillus fumigatus
Antifungal mechanisms of oregano essential oil against Aspergillus fumigatus Open
View article: A Mycorrhiza-Associated Receptor-like Kinase Regulates Disease Resistance in Rice
A Mycorrhiza-Associated Receptor-like Kinase Regulates Disease Resistance in Rice Open
Most terrestrial plants establish symbiotic relationships with microorganisms to acquire nutrients and simultaneously restrict pathogen infection. In rice, the receptor-like kinase OsARK1 is essential for the colonization and development o…
View article: A Novel Homozygous Nonsense Pathogenic Variant of the <i>CPAMD8</i> Gene Associated With Congenital Microcoria
A Novel Homozygous Nonsense Pathogenic Variant of the <i>CPAMD8</i> Gene Associated With Congenital Microcoria Open
Congenital microcoria (MCOR) is a rare inherited ocular disorder. Here, we describe a novel nonsense variant in the CPAMD8 gene in a patient with MCOR. We conducted a comprehensive clinical examination of a patient diagnosed with MCOR and …
View article: The Global Transcription Factor FvCon7 Plays a Role in the Morphology, FB1 Toxin Production, and Pathogenesis of Fusarium verticillioides
The Global Transcription Factor FvCon7 Plays a Role in the Morphology, FB1 Toxin Production, and Pathogenesis of Fusarium verticillioides Open
Fusarium verticillioides, an important global pathogenic fungus, compromises crop quality and yield by infecting maize, sugarcane, and some Solanaceae, endangering food security through contaminated grains and cereals with the fumonisin B1…
View article: <scp>MoMad2</scp> With a Conserved Function in the Spindle Assembly Checkpoint Is Required for Maintaining Appressorial Turgor Pressure and Pathogenicity of Rice Blast Fungus
<span>MoMad2</span> With a Conserved Function in the Spindle Assembly Checkpoint Is Required for Maintaining Appressorial Turgor Pressure and Pathogenicity of Rice Blast Fungus Open
Mad2, a conserved core component of the spindle assembly checkpoint (SAC) in eukaryotes, delays anaphase onset in case of incorrect kinetochore‐microtubule attachment. However, its functions in plant‐pathogenic fungi remain largely unknown…
View article: Rise and Fall of Phytophthora infestans Resistance to Non-Specific Fungicide in Experimental Populations
Rise and Fall of Phytophthora infestans Resistance to Non-Specific Fungicide in Experimental Populations Open
Background: Fungicide resistance is one of the major factors threatening social and ecological sustainability. Many issues associated with the evolutionary processes and mechanisms of fungicide resistance in pathogens remain poorly underst…
View article: Corneal stromal microdots accumulation and its association with corneal neurodegeneration and retinal microvascular perfusion in diabetes
Corneal stromal microdots accumulation and its association with corneal neurodegeneration and retinal microvascular perfusion in diabetes Open
Purpose The purpose of the study was to investigate the deposition of microdots in corneal stroma in diabetes mellitus (DM) patients and assess the relationship between microdots and corneal nerve damage as well as retinal microvascular pe…
View article: Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function
Aldehyde Oxidase 1 Deficiency Enhances Aerobic Exercise Performance by Promoting Skeletal Muscle Adaptation and Improving Mitochondrial Function Open
Aerobic exercise has significant health benefits, including preventing chronic diseases like sarcopenia. It strongly depends on muscle fiber types, with higher oxidative fiber ratios enhancing endurance. However, the molecular mechanisms u…
View article: Lipidomics and untargeted metabolomics analysis in elderly disabled patients
Lipidomics and untargeted metabolomics analysis in elderly disabled patients Open
Background In this study, we explored the to the changes in lipid metabolism and differentially expressed metabolites in elderly disabled patients by using Lipidomic profiling and untargeted metabolomics approach. Methods and Results Patie…
View article: Identification and characterization of DFR gene family and cloning of candidate genes for anthocyanin biosynthesis in pepper (Capsicum annuum L.)
Identification and characterization of DFR gene family and cloning of candidate genes for anthocyanin biosynthesis in pepper (Capsicum annuum L.) Open
View article: The <i>Xenopyricularia zizaniicola</i> exhibits a genome architecture distinct to the two-speed genome
The <i>Xenopyricularia zizaniicola</i> exhibits a genome architecture distinct to the two-speed genome Open
The fungal pathogens exhibit diverse genome architecture, which facilitates the host adaptation. Although increasing high-quality genomic data enable insights into the genome architecture of many fungal pathogens during the last decades, g…
View article: Recent advances in I/E-skin: mechanism, signal processing, and applications
Recent advances in I/E-skin: mechanism, signal processing, and applications Open
View article: Fermentation Preparation of Umami Sauce and Peptides from Kelp Scraps by Natural Microbial Flora
Fermentation Preparation of Umami Sauce and Peptides from Kelp Scraps by Natural Microbial Flora Open
Kelp (Laminaria japonica) is renowned for its rich content of flavor-enhancing amino acids and nucleotides; however, approximately 40% of kelp, including the thin edges and root areas, is discarded during its processing due to its inferior…
View article: The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus
The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus Open
Many fungal pathogens develop specialized infection structures such as appressoria to penetrate plant cells. However, it is not clear whether special structures are formed after cell wall penetration before invading host plasma membrane in…
View article: Author response: The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus
Author response: The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus Open
View article: Recycling of Trans‐Golgi SNAREs Promotes Apoplastic Effector Secretion for Effective Host Invasion in <i>Magnaporthe oryzae</i>
Recycling of Trans‐Golgi SNAREs Promotes Apoplastic Effector Secretion for Effective Host Invasion in <i>Magnaporthe oryzae</i> Open
Vesicle transport is crucial for pathogenic fungi, but the mechanisms that control the secretion of effector proteins are not yet fully understood. Here, we have uncovered a novel pathway in which retromer and trans‐Golgi (TGN) SNARE prote…
View article: Type 2C Protein Phosphatase MoPtc6 Plays Critical Roles in the Development and Virulence of Magnaporthe oryzae
Type 2C Protein Phosphatase MoPtc6 Plays Critical Roles in the Development and Virulence of Magnaporthe oryzae Open
Rice blast caused by Magnaporthe oryzae pathotype is the worst disease that leads to serious food insecurity globally. Understanding rice blast disease pathogenesis is therefore essential for the development of a blast disease mitigation s…
View article: MoPtc6, a Type 2C Protein Phosphatase Plays Critical Roles in the Development and Virulence of <i>Magnaporthe oryzae</i>
MoPtc6, a Type 2C Protein Phosphatase Plays Critical Roles in the Development and Virulence of <i>Magnaporthe oryzae</i> Open
Rice blast caused by Magnaporthe oryzae pathotype is the worst disease that leads to serious food insecurity globally. Understanding rice blast disease pathogenesis is therefore essential for development of blast disease mitigation strateg…
View article: Protein Phosphatases MoPtc5, MoPtc1, and MoPtc2 Contribute to the Vegetative Growth, Stress Adaptation, and Virulence of Magnaporthe oryzae
Protein Phosphatases MoPtc5, MoPtc1, and MoPtc2 Contribute to the Vegetative Growth, Stress Adaptation, and Virulence of Magnaporthe oryzae Open
Protein phosphatases are crucial enzymes that regulate key cellular processes such as the cell cycle, gene transcription, and translation in eukaryotes. Seven PP2C protein phosphatases have been identified in Magnaporthe oryzae. However, t…
View article: Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution
Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution Open
Background The endoplasmic reticulum (ER) serves as a crucial hub for protein synthesis and processing, playing an essential role in maintaining protein homeostasis. Perturbations, such as hypoxia, oxidative stress, inadequate amino acid s…
View article: A rapid and sensitive extraction-free HiFi-LAMP assay for detecting Mycobacterium leprae
A rapid and sensitive extraction-free HiFi-LAMP assay for detecting Mycobacterium leprae Open
The standard and/or extraction-free HiFi-LAMP assays can be used for detecting and monitoring M. leprae in endemic areas in resource-limited settings.
View article: The Identification of a Unique Gene MoUNG Required for Growth, Conidiation, and Pathogenicity in Magnaporthe oryzae Through T-DNA Insertion Mutagenesis
The Identification of a Unique Gene MoUNG Required for Growth, Conidiation, and Pathogenicity in Magnaporthe oryzae Through T-DNA Insertion Mutagenesis Open
Unique genes refer to genes specific to a particular organism and play crucial roles in the biological functions, evolutionary processes, and adaptations to external environments. However, the roles of unique genes in plant pathogenic fung…
View article: A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging
A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging Open
View article: Fermentation Preparation of Umami Peptides from Kelp Scraps by Natural Microbial Flora
Fermentation Preparation of Umami Peptides from Kelp Scraps by Natural Microbial Flora Open
View article: Urban Sewage Treatment Monitoring Based on 3DEEM Regional PCA
Urban Sewage Treatment Monitoring Based on 3DEEM Regional PCA Open
Urban sewage treatment, as a key task of modern environmental engineering, plays a crucial role in ensuring public health, environmental protection, and sustainable utilization of water resources. However, as the concentration and types of…
View article: Digitalization Solution for Carbon Capture, Transportation, Utilization, and Storage
Digitalization Solution for Carbon Capture, Transportation, Utilization, and Storage Open
View article: Comparison of differences in transcriptional and genetic profiles between intra-central nervous system and extra-central nervous system large B-cell lymphoma
Comparison of differences in transcriptional and genetic profiles between intra-central nervous system and extra-central nervous system large B-cell lymphoma Open