Zhenchang Wang
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View article: Associations of cardiovascular health and social determinants of health with the risks of all-cause and cause-specific mortality
Associations of cardiovascular health and social determinants of health with the risks of all-cause and cause-specific mortality Open
Background While cardiovascular health (CVH) and social determinants of health (SDoH) are independently associated with mortality, their combined effects on mortality remain unclear. The study aimed to examine the mediating, interacting, a…
View article: Decoding cancer heterogeneity through super-enhancer landscapes: from subtype discovery to therapeutic opportunity
Decoding cancer heterogeneity through super-enhancer landscapes: from subtype discovery to therapeutic opportunity Open
Super-enhancers (SEs) are clusters of enhancers with potent regulatory capabilities. They play a crucial role in shaping cellular identity and driving the progression of various diseases, including cancer. SEs exhibit significant heterogen…
View article: Photothermal and Combinatory Therapy as an Emerging Therapeutic Paradigm of Breast Cancer Treatment
Photothermal and Combinatory Therapy as an Emerging Therapeutic Paradigm of Breast Cancer Treatment Open
Breast cancer has a high mortality rate and is one of the most common malignancies among women. Conventional therapies such as radiotherapy, chemotherapy, and surgery are not sufficiently effective and have notable drawbacks, including tox…
View article: The CT-based attenuation index of peri-bowel adipose tissue can predict disease progression in inflammatory bowel disease patients
The CT-based attenuation index of peri-bowel adipose tissue can predict disease progression in inflammatory bowel disease patients Open
Objectives Peri-bowel fat inflammation is a prominent feature of inflammatory bowel disease (IBD). The peri-bowel fat attenuation index (FAI) can capture fat inflammation on abdominal CT. This study aimed to investigate the prognostic valu…
View article: First-in-Human, Open-Label, Within-Patient Controlled Study to Evaluate an Extensively Humanized Porcine Donor
First-in-Human, Open-Label, Within-Patient Controlled Study to Evaluate an Extensively Humanized Porcine Donor Open
Recent human decedent model studies and compassionate xenograft use have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must be engineered and its xenograft s…
View article: Photothermal Combination Therapy for Metastatic Breast Cancer: A New Strategy and Future Perspectives
Photothermal Combination Therapy for Metastatic Breast Cancer: A New Strategy and Future Perspectives Open
Metastatic breast cancer (MBC) remains one of the most aggressive and fatal malignancies in women, primarily due to tumor heterogeneity, multidrug resistance, and the limitations of conventional therapeutic approaches. Aim: This review aim…
View article: A Knowledge-Guided Dual-Path Framework for Automated Liver MRI Sequence Classification
A Knowledge-Guided Dual-Path Framework for Automated Liver MRI Sequence Classification Open
Purpose Accurate identification of liver MRI sequences and phases is crucial for streamlining clinical workflows, yet current automated methods remain limited in coverage and robustness for real-world practice. This study aims to develop a…
View article: Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest
Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest Open
This study aimed to investigate cervical vessel hemodynamics during 7 days of -6° head-down tilt (HDT) bed rest (BR) and 5 days of recovery in 40 healthy males, focusing on bilateral analysis and dynamic temporal monitoring. Diameter, flow…
View article: Associations of carotid flow velocity with cerebral perfusion and cerebral small vessel disease: a community-based prospective study
Associations of carotid flow velocity with cerebral perfusion and cerebral small vessel disease: a community-based prospective study Open
View article: SimPoly: Simulation of Polymers with Machine Learning Force Fields Derived from First Principles
SimPoly: Simulation of Polymers with Machine Learning Force Fields Derived from First Principles Open
Polymers are a versatile class of materials with widespread industrial applications. Advanced computational tools could revolutionize their design, but their complex, multi-scale nature poses significant modeling challenges. Conventional f…
View article: FlexRibbon: Joint Sequence and Structure Pretraining for Protein Modeling
FlexRibbon: Joint Sequence and Structure Pretraining for Protein Modeling Open
Protein foundation models have advanced rapidly, with most approaches falling into two dominant paradigms. Sequence-only language models (e.g., ESM-2) capture sequence semantics at scale but lack structural grounding. MSA-based predictors …
View article: Correlation Between Hemodynamic Characterizations of Cervical Arteries and Changes in Cerebral Microcirculation Under Dobutamine Stress: A Self- Controlled Study
Correlation Between Hemodynamic Characterizations of Cervical Arteries and Changes in Cerebral Microcirculation Under Dobutamine Stress: A Self- Controlled Study Open
Background Dobutamine, an inotropic agent, is known to enhance cardiac function. However, its concurrent effects on cervical artery hemodynamics and cerebral microcirculation, along with their potential correlation, remain unclear. This st…
View article: 2025 Expert consensus on retrospective evaluation of large language model applications in clinical scenarios
2025 Expert consensus on retrospective evaluation of large language model applications in clinical scenarios Open
View article: An original method of straw returning enhanced the improvement effect of saline-alkali soil, thereby promoting the growth of tomatoes
An original method of straw returning enhanced the improvement effect of saline-alkali soil, thereby promoting the growth of tomatoes Open
View article: Research on detection and counting method of wheat ears in the field based on YOLOv11-EDS
Research on detection and counting method of wheat ears in the field based on YOLOv11-EDS Open
Introduction As a major food crop, accurate detection and counting of wheat ears in the field are of great significance for yield estimation. Aiming at the problems of low detection accuracy and large computational load of existing detecti…
View article: Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline
Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline Open
Background High blood pressure (BP) is a known risk factor for cognitive decline and dementia, but the underlying mechanisms are largely unknown. We investigated the associations of cumulative BP exposure with hippocampal subfield volume a…
View article: Association between early serum uric acid levels and diffusion tensor imaging analysis along the perivascular space with cognitive function
Association between early serum uric acid levels and diffusion tensor imaging analysis along the perivascular space with cognitive function Open
Serum uric acid (SUA) demonstrates dual roles as both an antioxidant and a pro‐oxidant; however, its long‐term effects on glymphatic function and cognitive performance remain unclear. This study included 944 participants in a longitudinal …
View article: Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancer
Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancer Open
As a clinically heterogeneous breast cancer subtype, triple-negative breast cancer (TNBC) currently lacks effective targeted therapies. The subtype-specific heterogeneity of tumor phenotypes and gene expression programs poses challenges fo…
View article: Current Status and Challenges of Artificial Intelligence in Computed To-mography Radiation Dose Optimization
Current Status and Challenges of Artificial Intelligence in Computed To-mography Radiation Dose Optimization Open
View article: Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus
Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus Open
Our findings demonstrate extensive AC changes in bilateral TE3.0, offering new insights into the mechanism of tinnitus. The sound therapy efficacy may be linked to individual differences in AC subregion reorganization, with combined FC val…
View article: Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study
Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study Open
Objective We aimed to investigate the influence of Life’s Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD). Methods A total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 scor…
View article: Ophthalmic changes are associated with visual cortex functional network reorganization after 90-day head-down tilt bed rest
Ophthalmic changes are associated with visual cortex functional network reorganization after 90-day head-down tilt bed rest Open
OBF may be a key risk factor for decreased visual acuity in stimulated microgravity, potentially driving functional network reorganization of the visual cortex by modifying visual function. These insights contribute to a new insight for op…
View article: Global knowledge mapping and emerging research trends in non-coding RNAs related to animal and plant male sterility: A visual analysis of CiteSpace maps
Global knowledge mapping and emerging research trends in non-coding RNAs related to animal and plant male sterility: A visual analysis of CiteSpace maps Open
Animal and plant male sterility is a complex and closely studied phenomenon that significantly impacts species survival and reproduction. Advances in biotechnology and molecular biology have deepened our understanding of gene expression re…
View article: Early alterations of the cartilage–subchondral bone unit in spontaneous osteoarthritis
Early alterations of the cartilage–subchondral bone unit in spontaneous osteoarthritis Open
View article: Trust Region Preference Approximation: A simple and stable reinforcement learning algorithm for LLM reasoning
Trust Region Preference Approximation: A simple and stable reinforcement learning algorithm for LLM reasoning Open
Recently, Large Language Models (LLMs) have rapidly evolved, approaching Artificial General Intelligence (AGI) while benefiting from large-scale reinforcement learning to enhance Human Alignment (HA) and Reasoning. Recent reward-based opti…
View article: Correlation of Physical Activity and Sleep Quality with Metabolic-Associated Fatty Liver Disease in Community-Based Older Adults
Correlation of Physical Activity and Sleep Quality with Metabolic-Associated Fatty Liver Disease in Community-Based Older Adults Open
Purpose: Physical inactivity has been identified as a potential risk factor for metabolic-associated fatty liver disease (MAFLD) in the elderly. However, the specific effects of different types and intensities of physical activity on MAFLD…
View article: Blood flow changes in the transverse-sigmoid sinus junction following effective surgical reconstruction for unilateral pulsatile tinnitus with sigmoid sinus wall anomalies: a four-dimensional flow magnetic resonance imaging analysis
Blood flow changes in the transverse-sigmoid sinus junction following effective surgical reconstruction for unilateral pulsatile tinnitus with sigmoid sinus wall anomalies: a four-dimensional flow magnetic resonance imaging analysis Open
Surgical reconstruction does not appear to have a significant effect on PT-related blood flow properties, which suggests that this surgery is safe; however, the risk of ongoing recurrence remains.
View article: Alterations of diffusion kurtosis measures in gait-related white matter in the “ON–OFF state” of Parkinson’s disease
Alterations of diffusion kurtosis measures in gait-related white matter in the “ON–OFF state” of Parkinson’s disease Open
Background: Gait impairment is closely related to quality of life in patients with Parkinson’s disease (PD). This study aimed to explore alterations in brain microstructure in PD patients and healthy controls (HCs) and to identify the corr…
View article: Distance Learning During the COVID-19 Lockdown and Self-Assessed Competency Development Among Radiology Residents in China: Cross-Sectional Survey
Distance Learning During the COVID-19 Lockdown and Self-Assessed Competency Development Among Radiology Residents in China: Cross-Sectional Survey Open
Background During the COVID-19 lockdown, it was difficult for residency training programs to conduct on-site, hands-on training. Distance learning, as an alternative to in-person training, could serve as a viable option during this challen…
View article: HybriDNA: A Hybrid Transformer-Mamba2 Long-Range DNA Language Model
HybriDNA: A Hybrid Transformer-Mamba2 Long-Range DNA Language Model Open
Advances in natural language processing and large language models have sparked growing interest in modeling DNA, often referred to as the "language of life". However, DNA modeling poses unique challenges. First, it requires the ability to …