Wangdong Jin
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View article: Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms
Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms Open
Considering the high metastatic potential of osteosarcoma, not only pro‑apoptosis, but also anti‑metastasis is important for anti‑osteosarcoma therapy. Previously, the authors reported the pro‑apoptotic and tumor‑inhibitory effects of thea…
View article: Theabrownin triggers <scp>DNA</scp> damage to suppress human osteosarcoma U2<scp>OS</scp> cells by activating p53 signalling pathway
Theabrownin triggers <span>DNA</span> damage to suppress human osteosarcoma U2<span>OS</span> cells by activating p53 signalling pathway Open
Osteosarcoma becomes the second leading cause of cancer death in the younger population. Current outcomes of chemotherapy on osteosarcoma were unsatisfactory to date, demanding development of effective therapies. Tea is a commonly used bev…
View article: Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism
Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism Open
Green tea, the fresh leaves of Camellia sinensis, is not only a health-promoting beverage but also a traditional Chinese medicine used for prevention or treatment of cancer, such as lung cancer. Theabrownin (TB) is the main fraction…
View article: Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells
Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells Open
With the highest cancer incidence rate, lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer death in the world. Tea (leaves of Camellia sinensis) has been widely used as a traditional beverage …
View article: In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae
In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae Open
Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. To date, no toxicity or adve…
View article: Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish
Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish Open
Quetiapine fumarate (QF) is a widely used antipsychotic agent for the first-line treatment of schizophrenia, with good tolerability and compliance in humans and no observed adverse effects against liver. Taking advantages of zebrafish, whi…