Explanipedia

First Report of Curvularia pseudobrachyspora Causing Leaf Blight on Nageia fleuryi Open

Peiwen Yang, Lele Mu, You‐Zhao Lan, Bin Lin, Wang‐Dong Xu , et al. · 2025

A severe leaf blight disease was observed on Nageia fleuryi in Fuzhou, China, during 2022–2023, causing necrosis on more than 60% of young leaves in both urban and plantation trees. This study aimed to identify the causal agent of the dise…

An Efficient Machine Learning Pipeline for Distinguishing Cancer and Non‐Cancer Patients in Systemic Lupus Erythematosus Open

You‐Yue Chen, An‐Fang Huang, Jing Yang, Lu Fu, Wang‐Dong Xu · 2025

Background The objective is to develop a machine learning model that is capable of effectively distinguishing between cancer and non‐cancer patients among systemic lupus erythematosus (SLE). Methods A total of 2811 patients with SLE were i…

Transcriptome Analysis of the Pathogenic Mechanism of the Novel Pathogenic Fungus Bipolaris fujianensis in Chinese Fir (Cunninghamia lanceolata) Shoot Blight Open

Bin Lin, Pei-Wen Yang, Ruifeng Luo, Ying Lü, Yiran Li , et al. · 2025

Bipolaris fujianensis is a novel pathogenic species causing Chinese fir (Cunninghamia lanceolata) shoot blight (CFSB), first discovered in Nanping City, Fujian Province. However, its molecular pathogenic mechanisms remain largely unknown. …

Butyrophilin 3A1 Contributes to Inflammation and Induces a Lupus‐Like Disease by Inhibiting the IL‐38‐Ferroptosis Axis Open

Wang‐Dong Xu, Dacheng Wang, Yang‐Yang Tang, Qi Huang, Lu Fu , et al. · 2025

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin. Recent evidence has linked butyrophilin 3A1 (BTN3A1) to immune dysregulation. This study was to elucidate the relationship of BTN3A1 in SLE. Expression of BTN3A…

Targeting Th9 cells in autoimmune diseases: a narrative review Open

Wang‐Dong Xu, You‐Yue Chen, Yunwei Li, Jing Yang, An‐Fang Huang · 2025

T helper 9 (Th9) cells are a newly identified subset of effector T cells, characterized by their production of IL-9, a hallmark cytokine. Transcription factors such as PU.1 and IRF4 bind to the IL9 gene promoter and transactivate its expre…

Serum globulin trajectory discovery and prediction in systemic lupus erythematosus: Results from a real‐world observational cohort study Open

Yang‐Yang Tang, Linchong Su, Zhen Qin, Guo‐Cui Wu, You‐Yu Lan , et al. · 2024

Systemic lupus erythematosus (SLE) patients complicated with lupus nephritis, arthritis, and butterfly-shaped erythema each reflect abnormal inflammatory state of patients.1 SLE patients have chronic inflammation, which usually gives rise …

An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases Open

Wang‐Dong Xu, Da‐Cheng Wang, Ming Zhao, An‐Fang Huang · 2024

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus (EBV)-induced gene 3 (Ebi3) and IL-27p28.…

Fabrication of Functionalized Composite Aerogel Zif-8@B-Cnf With Enhanced Photocatalytic Performance Open

Yuan Shuo, Kaiqing Wang, Wang‐Dong Xu, Xin Yu, Zhexiu Liu , et al. · 2024

Th1-related transcription factors and cytokines in systemic lupus erythematosus Open

Yang‐Yang Tang, Dacheng Wang, You‐Yue Chen, Wang‐Dong Xu, An‐Fang Huang · 2023

Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells, transcription factor T-bet, and related cytokines IFNγ, TNFα, IL-2, IL-18, TGF-β, and IL-12 have been …

Biology of endophilin and it’s role in disease Open

Lu-Qi Yang, An‐Fang Huang, Wang‐Dong Xu · 2023

Endophilin is an evolutionarily conserved family of protein that involves in a range of intracellular membrane dynamics. This family consists of five isoforms, which are distributed in various tissues. Recent studies have shown that Endoph…

Association between endothelin-1 and systemic lupus erythematosus: insights from a case–control study Open

Rong Li, Chan Yang, Yang‐Yang Tang, Dacheng Wang, Wang‐Dong Xu , et al. · 2023

Systemic lupus erythematosus (SLE) is a chronic rheumatic disorder. Endothelin-1, a vasoconstrictor, belongs to the endothelin family and is associated with vascular-related damages. To date, association between ET-1 and pathogenesis of SL…

Lupus nephritis or not? A simple and clinically friendly machine learning pipeline to help diagnosis of lupus nephritis Open

Dacheng Wang, Wang‐Dong Xu, Shennan Wang, Xiang Wang, Wei Leng , et al. · 2023

GeoNet: Benchmarking Unsupervised Adaptation across Geographies Open

Tarun Kalluri, Wang‐Dong Xu, Manmohan Chandraker · 2023

In recent years, several efforts have been aimed at improving the robustness of vision models to domains and environments unseen during training. An important practical problem pertains to models deployed in a new geography that is under-r…

Superhydrophobic and easy-to-clean full-packing nanopatterned microlens array with high-quality imaging Open

Chaolong Fang, Wang‐Dong Xu, Libo Zhu, Youyi Zhuang, Dawei Zhang · 2023

The high-quality imaging and easy cleaning property of microlens array (MLA) are two very important factors for its outdoor work. Herein, a superhydrophobic and easy-to-clean full-packing nanopatterned MLA with high-quality imaging is prep…

Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review Open

Yang‐Yang Tang, Dacheng Wang, Youqiang Wang, An‐Fang Huang, Wang‐Dong Xu · 2023

Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β ce…

Endothelin-1, a marker for systemic lupus erythematosus? Open

Rong Li, Chan Yang, Yang‐Yang Tang, Dacheng Wang, An‐Fang Huang , et al. · 2023

Objective : Systemic lupus erythematosus is a chronic rheumatic disorder. Endothelin-1, a vasoconstrictor, belongs to the endothelin family. To date, association between ET-1 and pathogenesis of SLE remains unclear. Method : This case-cont…

Application of T‐cell receptor repertoire as a novel monitor in dynamic tracking and assessment: A cohort‐study based on <span>RA</span> patients Open

Peiqing Yang, Yijing He, Pingying Qing, Wang‐Dong Xu, Dan Xie , et al. · 2022

T‐cell receptor repertoire (TCRR) sequencing has been widely applied in many fields as a novel tool. This study explored characteristics of TCRR in detail with a cohort of 598 rheumatoid arthritis (RA) patients before and after anti‐rheuma…

Clinical significance of T cell receptor repertoire in primary Sjogren's syndrome Open

Chenyang Lu, Xuenan Pi, Wang‐Dong Xu, Pingying Qing, Honghu Tang , et al. · 2022

GDF-15: A Potential Biomarker and Therapeutic Target in Systemic Lupus Erythematosus Open

Wang‐Dong Xu, Qi Huang, Chan Yang, Rong Li, An‐Fang Huang · 2022

Systemic lupus erythematosus (SLE) is a rheumatic disease. Growth differentiation factor 15 (GDF-15) is a member of transforming growth factor-β superfamily. To date, association of GDF-15 with SLE pathogenesis is not clarified. This study…

Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review Open

Wang‐Dong Xu, Rong Li, An‐Fang Huang · 2022

TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune cell, for example, synovial fibroblast, endothelial cell.…

Association and interaction between dietary patterns and gene polymorphisms in Liangshan residents with hyperuricemia Open

Tingting Li, Shuangjing Li, Tian Tian, Zhichao Nie, Wang‐Dong Xu , et al. · 2022

Association of CD40 Gene Polymorphisms With Systemic Lupus Erythematosus and Rheumatoid Arthritis in a Chinese Han Population Open

Qi Huang, Wang‐Dong Xu, Linchong Su, Xiaoyan Liu, An‐Fang Huang · 2021

Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases. CD40 participates in inflammatory response, and promotes fibroblast proliferation, leading to occurrence and progression of SLE, RA. This stu…

Detrimental effects of long-term elevated serum uric acid on cognitive function in rats Open

Tian Tian, Xi-run Liu, Tingting Li, Zhichao Nie, Shuang‐Jing Li , et al. · 2021

Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients Open

Jiamin Wang, Wang‐Dong Xu, Zhi‐Chao Yuan, Qian Wu, Jie Zhou , et al. · 2021

IL‐38: A novel cytokine in systemic lupus erythematosus pathogenesis Open

Wang‐Dong Xu, Linchong Su, Xiaoyan Liu, Jia‐Min Wang, Zhi‐Chao Yuan , et al. · 2020

IL‐38 is a newly identified cytokine that belongs to the IL‐1 family. In our previous study, we found elevated plasma levels of IL‐38 in patients with systemic lupus erythematosus (SLE). However, the clear relationship of IL‐38 expression …

Gene polymorphisms and serum levels of sVEGFR-1 in patients with systemic lupus erythematosus Open

Zhi‐Chao Yuan, Wang‐Dong Xu, Jiamin Wang, Qian Wu, Jie Zhou , et al. · 2020

Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus Open

Wang‐Dong Xu, Xiaoyan Liu, Linchong Su, An‐Fang Huang · 2020

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder. MASP2 is a mediator that plays an important role in complement system. As dysregulation of the complement system has been demonstrated to correlate with SLE …

Analysis of renal function in a Health Examination Population in Chengdu (2012-2018) Open

Ruicen Li, Ting Bao, Hanwei Yang, Wang‐Dong Xu, Huairong Tang · 2020

Background Dysfunction of kidney correlates with multiple renal diseases, for instance, chronic kidney disease. However, monitoring the changes of indexes related to renal function may help to early find the potential patients with renal d…

Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases Open

Zhi‐Chao Yuan, Wang‐Dong Xu, Xiaoyan Liu, Xingyou Liu, An‐Fang Huang , et al. · 2019

Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal …

Insights into IL‐29: Emerging role in inflammatory autoimmune diseases Open

Jia‐Min Wang, An‐Fang Huang, Wang‐Dong Xu, Linchong Su · 2019

Interleukin‐29 (IL‐29) is a newly discovered member of type III interferon. It mediates signal transduction via binding to its receptor complex and activates downstream signalling pathways, and therefore induces the generation of inflammat…

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