Wangjianfei Yu
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View article: <scp>KRT80</scp> in hepatocellular carcinoma plays oncogenic role via epithelial–mesenchymal transition and <scp>PI3K</scp>/<scp>AKT</scp> pathway
<span>KRT80</span> in hepatocellular carcinoma plays oncogenic role via epithelial–mesenchymal transition and <span>PI3K</span>/<span>AKT</span> pathway Open
Hepatocellular carcinoma (HCC), a globally prevalent form of cancer, is featured by aggressive growth and early metastasis. Elucidating the underlying mechanism and identifying the effective therapy are critical for advanced HCC patients. …
View article: Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma
Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma Open
Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune and epithelial cells. It plays a rol…
View article: Systematic analysis of TREM2 and its carcinogenesis in pancreatic cancer
Systematic analysis of TREM2 and its carcinogenesis in pancreatic cancer Open
In conclusion, our comprehensive analysis identified that TREM2 expression level was correlated with the TME and the immunosuppressive effects. In particular, our study indicated that TREM2 was involved in the progression of pancreatic can…
View article: A novel machine learning-derived four-gene signature predicts STEMI and post-STEMI heart failure
A novel machine learning-derived four-gene signature predicts STEMI and post-STEMI heart failure Open
High mortality and morbidity rates associated with ST-elevation myocardial infarction (STEMI) and post-STEMI heart failure (HF) necessitate proper risk stratification for coronary artery disease (CAD). A prediction model that combines spec…
View article: Transcriptomic Analysis Identifies Complement Component 3 as a Potential Predictive Biomarker for Chemotherapy Resistance in Colorectal Cancer
Transcriptomic Analysis Identifies Complement Component 3 as a Potential Predictive Biomarker for Chemotherapy Resistance in Colorectal Cancer Open
Objective: 5-fluorouracil- and oxaliplatin-based FOLFOX regimens are mainstay chemotherapeutics for colorectal cancer (CRC) but drug resistance represents a major therapeutic challenge. To improve patient survival, there is a need to ident…