Wanglin Li
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View article: Nuclear receptor Nr1d1 links sleep deprivation to intestinal homeostasis via microbiota-derived taurine
Nuclear receptor Nr1d1 links sleep deprivation to intestinal homeostasis via microbiota-derived taurine Open
Together, these findings reveal a gut microbiota-taurine-Nr1d1 axis underlying sleep deprivation-induced intestinal barrier dysfunction, and suggest that therapeutic modulation of taurine levels or circadian pathways may offer novel strate…
View article: Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer
Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer Open
Fusobacterium nucleatum ( Fn ) enrichment has been identified in colorectal cancer and its liver metastases. In this study, we found that Fn predominantly accumulated within colorectal cancer cells, correlating with colorectal cancer liver…
View article: SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression
SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression Open
Background Cell-cell crosstalk in the tumor microenvironment (TME) is crucial for cancer development and strongly correlates with clinical outcomes. Interpatient variability in tumor microenvironment composition and function poses ongoing …
View article: AMER1 expedites anti-tumor immunity of CD8+ T cells by enhancing cancer cell-derived dopamine secretion in colorectal cancer
AMER1 expedites anti-tumor immunity of CD8+ T cells by enhancing cancer cell-derived dopamine secretion in colorectal cancer Open
View article: LINC00460/miR-186-3p/MYC feedback loop facilitates colorectal cancer immune escape by enhancing CD47 and PD-L1 expressions
LINC00460/miR-186-3p/MYC feedback loop facilitates colorectal cancer immune escape by enhancing CD47 and PD-L1 expressions Open
Background Long non-coding RNAs (LncRNAs) have been implicated as critical regulators of cancer tumorigenesis and progression. However, their functions and molecular mechanisms in colorectal cancer (CRC) still remain to be further elucidat…
View article: Seed and Soil: Consensus Molecular Subgroups (CMS) and Tumor Microenvironment Features Between Primary Lesions and Metastases of Different Organ Sites in Colorectal Cancer
Seed and Soil: Consensus Molecular Subgroups (CMS) and Tumor Microenvironment Features Between Primary Lesions and Metastases of Different Organ Sites in Colorectal Cancer Open
Our findings underscore the importance of CMS-guided specific organ monitoring and treatment post-primary tumor surgery for patients. Differences in immune-stromal infiltration among different metastases provide targeted therapeutic opport…
View article: Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis
Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis Open
Background Colorectal cancer (CRC) is one of the most common malignancies in the world. This study proposes to reveal prognostic biomarkers for the prognosis and treatment of CRC patients. Methods Differential analysis of OSBPL3 was perfor…
View article: Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer Open
Background Immunotherapy, including adoptive cell therapy (ACT) and immune checkpoint inhibitors (ICIs), has a limited effect in most patients with colorectal cancer (CRC), and the efficacy is further limited in patients with liver metasta…
View article: Simple transanal total mesorectal resection versus laparoscopic transabdominal total mesorectal resection for the treatment of low rectal cancer: a single-center retrospective case-control study
Simple transanal total mesorectal resection versus laparoscopic transabdominal total mesorectal resection for the treatment of low rectal cancer: a single-center retrospective case-control study Open
Aim To evaluate the efficacy and safety of simple TaTNE in the treatment of low rectal cancer compared with laparoscopic transabdominal TME. Methods We collected patients with low rectal cancer admitted to our hospital between January 2019…
View article: Low Molecular Weight Heparin Synergistically Enhances the Effectiveness of Immunotherapy By Increasing Lymphocyte Infiltration in Colorectal Cancer
Low Molecular Weight Heparin Synergistically Enhances the Effectiveness of Immunotherapy By Increasing Lymphocyte Infiltration in Colorectal Cancer Open
View article: Colon cancer patient with long-term colon stent placement: Case report and literature review
Colon cancer patient with long-term colon stent placement: Case report and literature review Open
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality globally. Large bowel obstruction (occurring in 15-30% of patients with CRCs) accounts for approximately 80% of medical emergencies re…
View article: Correction: Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128
Correction: Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128 Open
View article: The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer
The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer Open
Objective The mesentery is a potential site of residual tumor in patients with colorectal cancer (CRC). However, the mesenteric immune microenvironment remains unclear. In this study, we investigated the immune landscape of the mesentery, …
View article: Risk Factors for Recurrence of Radically Resected Mucinous Colorectal Adenocarcinoma
Risk Factors for Recurrence of Radically Resected Mucinous Colorectal Adenocarcinoma Open
Intraoperative transfusion and N2 stage were significant predictors for local recurrence. Male sex, CA199, and T4 stage were significant predictors for distant metastasis. Knowledge of the risk factors for postoperative recurrence provides…
View article: Risk factors for recurrence of radically resected mucinous colorectal adenocarcinoma
Risk factors for recurrence of radically resected mucinous colorectal adenocarcinoma Open
Background Local recurrence and distant metastasis are major challenges to overcome in order to improve the survival of patients with colorectal cancer (CRC) after surgery. Mucinous adenocarcinoma (MA) is a subtype of CRC associated with a…
View article: Clinical efficacy of intersphincteric resection for low rectal cancer compared with abdominoperineal resection: a single-center retrospective study
Clinical efficacy of intersphincteric resection for low rectal cancer compared with abdominoperineal resection: a single-center retrospective study Open
Purpose In recent years, intersphincteric resection (ISR) has been increasingly used to replace abdominoperineal resection (APR) for low rectal cancer. This study was to compare the clinical efficacy of ISR and APR. Methods Between 2012 an…
View article: Death-inducer obliterator 1 (DIDO1) silencing suppresses the growth of bladder cancer cells through decreasing SAPK/JNK signaling cascades
Death-inducer obliterator 1 (DIDO1) silencing suppresses the growth of bladder cancer cells through decreasing SAPK/JNK signaling cascades Open
Death inducer obliterator (DIDO) is involved in apoptosis and embryonic stem cell self-renewal. Here, we investigate the effect of DIDO1 on bladder cancer cells and clarify the underlying molecular mechanism. Bladder cancer tissues and cel…
View article: Glove single-port laparoscopy-assisted transanal total mesorectal excision for low rectal cancer: a preliminary report
Glove single-port laparoscopy-assisted transanal total mesorectal excision for low rectal cancer: a preliminary report Open
View article: Analysis of population‐based colorectal cancer screening in Guangzhou, 2011‐2015
Analysis of population‐based colorectal cancer screening in Guangzhou, 2011‐2015 Open
Objective To analyze the detection rates of colorectal cancer (CRC) and polyps by population‐based screening in Guangzhou. Methods From January 2011 to December 2015, the residents aged 30‐79 were selected for CRC screening. The residents …
View article: Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks
Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks Open
The current study aimed to develop multiple diagnosis models for colorectal cancer (CRC) based on data from The Cancer Genome Atlas database and analysis with artificial neural networks in order to enhance CRC diagnosis methods. A genetic …
View article: Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128
Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128 Open
View article: Long non‑coding RNA 00152 functions as a competing endogenous RNA to regulate NRP1 expression by sponging with miRNA‑206 in colorectal cancer
Long non‑coding RNA 00152 functions as a competing endogenous RNA to regulate NRP1 expression by sponging with miRNA‑206 in colorectal cancer Open
Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non‑coding RNAs (l…
View article: Gambogic acid reverses oxaliplatin resistance in colorectal cancer by increasing intracellular platinum levels
Gambogic acid reverses oxaliplatin resistance in colorectal cancer by increasing intracellular platinum levels Open
Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resi…
View article: Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer
Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer Open
The present study investigated the expression and clinical significance of flavin-containing monooxygenase 5 (FMO5) in colorectal cancer (CRC). The expression of FMO5 was detected by immunohistochemistry in 208 colon cancer tissues and 8 n…
View article: Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression
Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression Open
Background/Aims: Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been reported to be a potential novel antitumor drug. Whether GA inhibits putative cancer stem cells (CSCs), which are considered to be the major cause …
View article: Expression of EZH2 is associated with poor outcome in colorectal cancer
Expression of EZH2 is associated with poor outcome in colorectal cancer Open
Enhancer of zeste homolog 2 (EZH2), the critical component of polycomb group protein family, has been demonstrated to be overexpressed in various types of human cancer, including hepatocellular carcinoma, breast, bladder and lung cancer. T…
View article: Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients
Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients Open
Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present st…
View article: Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis
Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis Open
Chemotherapy using 5-fluorouracil (5-FU) for colorectal cancer (CRC) has low specificity and response rates, leading to severe side effects. Gambogic acid (GA), a traditional Chinese medicine, has multi-targeted anticancer effects, includi…
View article: Modalities of ventricular pacing for cardiac resynchronization therapy in patients with heart failure: a meta-analysis and systematic review
Modalities of ventricular pacing for cardiac resynchronization therapy in patients with heart failure: a meta-analysis and systematic review Open
TriV CRT is an attractive alternative to univentricular or BiV pacing for heart failure patients. It is necessary to conduct further large randomized trials to validate our present data.
View article: Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction
Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction Open