Wangting Xu
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View article: Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies
Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies Open
Ferroptosis is a distinct form of iron‐dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, iron metabolism, lipid …
View article: MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies
MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies Open
View article: Gut–Brain–Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors
Gut–Brain–Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors Open
Accumulating evidence demonstrates crosstalk involving the intestine and the brain, with the gut microbiota serving as a critical mediator of this interaction. The gut microbiota, along with its derived metabolites and bioactive compounds,…
View article: Targeting <i>SLC7A11</i> /xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti‐tumor immune response
Targeting <i>SLC7A11</i> /xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti‐tumor immune response Open
After RFA treatment in patients with liver cancer, the expression of SLC7A11/xCT and the proportion of DCs in the TME were significantly increased. SLC7A11/xCT is a poor prognostic marker for liver cancer and is mainly expres…
View article: NanoSHP099‐Targeted SHP2 Inhibition Boosts Ly6C <sup>low</sup> Monocytes/Macrophages Differentiation to Accelerate Thrombolysis
NanoSHP099‐Targeted SHP2 Inhibition Boosts Ly6C <sup>low</sup> Monocytes/Macrophages Differentiation to Accelerate Thrombolysis Open
Tumor‐associated thrombus (TAT) accounts for a high proportion of venous thromboembolism. Traditional thrombolysis and anticoagulation methods are not effective due to various complications and contraindications, which can easily lead to p…
View article: SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis
SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis Open
SIPRα on macrophages binds with CD47 to resist proengulfment signals, but how the downstream signal of SIPRα controls tumor-infiltrating macrophages (TIMs) is still poorly clarified. Here, we report that the CD47/signal regulatory protein …
View article: Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages
Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages Open
View article: Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway
Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway Open
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing unremitting extracellular matrix deposition. Transforming growth factor-β (TGF-β) superfamily involves bone morphogenetic proteins (BMPs) and TGF-β, and the balance …