Wangyuan Zou
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View article: Strong transverse Anderson localization in a PMMA-PS-air disordered optical fiber for ultra-broadband imaging
Strong transverse Anderson localization in a PMMA-PS-air disordered optical fiber for ultra-broadband imaging Open
View article: Efficacy of low-frequency repetitive transcranial magnetic stimulation combined with risperidone in the treatment of schizophrenia patients with auditory verbal hallucinations
Efficacy of low-frequency repetitive transcranial magnetic stimulation combined with risperidone in the treatment of schizophrenia patients with auditory verbal hallucinations Open
Objective: This study aimed to determine the efficacy and safety of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) combined with risperidone in the treatment of schizophrenia patients with auditory verbal hallucin…
View article: Neuro-immune regulation of sepsis-associated delirium via the PBN-CeA-spleen axis
Neuro-immune regulation of sepsis-associated delirium via the PBN-CeA-spleen axis Open
View article: The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis
The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis Open
Our findings provide genetic evidence supporting causal relationship for prescription opioid use on a high risk of fibromyalgia. This association remains robust after adjustment for MDD, ADs and insomnia. Given the potential for opioid pre…
View article: A neural circuit from paraventricular hypothalamic nucleus oxytocin neurons to trigeminal nucleus caudalis GABAergic neurons modulates pain sensitization in a mouse model of chronic migraine
A neural circuit from paraventricular hypothalamic nucleus oxytocin neurons to trigeminal nucleus caudalis GABAergic neurons modulates pain sensitization in a mouse model of chronic migraine Open
PVN OXT neurons exert a descending facilitatory effect on GABAergic neurons in the TNC via OXT release, thereby ameliorating pain sensitization in chronic migraine.
View article: A systematic review and meta-analysis of efruxifermin’s efficacy in improving liver fibrosis in patients with NASH/MASH
A systematic review and meta-analysis of efruxifermin’s efficacy in improving liver fibrosis in patients with NASH/MASH Open
Background & Aims Efruxifermin is a potential treatment for non-alcoholic steatohepatitis (NASH, now termed metabolic dysfunction-associated steatohepatitis, MASH). This study aimed to analyze the effectiveness of efruxifermin in impro…
View article: Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation
Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation Open
Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis. The role of annexin A3 (ANXA3) in regulating endothelial permeability and inflammation during sepsis is explored using AN…
View article: Microglial Annexin A3 Downregulation Alleviates Ischemic Injury by Inhibiting NF-κB/NLRP3-mediated Inflammation
Microglial Annexin A3 Downregulation Alleviates Ischemic Injury by Inhibiting NF-κB/NLRP3-mediated Inflammation Open
View article: Efficacy and safety of perioperative intravenous lidocaine infusion for chronic postoperative pain
Efficacy and safety of perioperative intravenous lidocaine infusion for chronic postoperative pain Open
View article: Individualized blood pressure regulation and acute kidney injury in older patients having major abdominal surgery: a pilot randomized trial
Individualized blood pressure regulation and acute kidney injury in older patients having major abdominal surgery: a pilot randomized trial Open
Background: Acute kidney injury (AKI) is a common postoperative complication, and hypotension may contribute. We therefore tested the primary hypothesis that individualized intraoperative blood pressure regulation reduces postoperative AKI…
View article: In reply: Fibreoptic or flexible bronchoscopy during bronchial blocker placement: time to stop perpetuating a bronchoscopic misnomer?
In reply: Fibreoptic or flexible bronchoscopy during bronchial blocker placement: time to stop perpetuating a bronchoscopic misnomer? Open
View article: Co‐delivery Nano System of MS‐275 and V‐9302 Induces Pyroptosis and Enhances Anti‐Tumor Immunity Against Uveal Melanoma
Co‐delivery Nano System of MS‐275 and V‐9302 Induces Pyroptosis and Enhances Anti‐Tumor Immunity Against Uveal Melanoma Open
In the treatment of uveal melanoma (UVM), histone deacetylase inhibitors (HDACi) have emerged as a promising epigenetic therapy. However, their clinical efficacy is hindered by the suboptimal pharmacokinetics and the strong self‐rescue of …
View article: Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception
Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception Open
Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-…
View article: Progress in study on animal models of trigeminal neuralgia.
Progress in study on animal models of trigeminal neuralgia. Open
Trigeminal neuralgia is a manifestation of orofacial neuropathic pain disorder, always deemed to be an insurmountable peak in the field of pain research and treatment. The pain is recurrent, abrupt in onset and termination similar to an el…
View article: Causal relationship of gut microbiota and metabolites on cognitive performance: A mendelian randomization analysis
Causal relationship of gut microbiota and metabolites on cognitive performance: A mendelian randomization analysis Open
Emerging evidence has indicated that the alterations in gut microbiota and metabolites are associated with cognitive performance. However, whether these associations imply a causal relationship remains to be definitively established. Here,…
View article: Advances of perioperative acute kidney injury in elderly patients undergoing non-cardiac surgery.
Advances of perioperative acute kidney injury in elderly patients undergoing non-cardiac surgery. Open
The risk of developing perioperative acute kidney injury (AKI) in elderly patients increases with age. The combined involvement of aging kidneys, coexisting multiple underlying chronic diseases, and increased exposure to potential renal st…
View article: Editorial: Modulation of neural circuits and plasticity underlying opioid analgesia, tolerance, and addiction
Editorial: Modulation of neural circuits and plasticity underlying opioid analgesia, tolerance, and addiction Open
EDITORIAL article Front. Neurosci., 04 April 2023Sec. Neuropharmacology Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1191030
View article: Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review
Prenatal anesthetic exposure and offspring neurodevelopmental outcomes—A narrative review Open
While it is common for pregnant women to take anesthesia during surgery, the effects of prenatal anesthesia exposure (PAE) on the long-term neurodevelopment of the offspring remain to be clarified. Preclinical animal research has shown tha…
View article: The correlation of intraoperative oliguria with acute kidney injury after noncardiac surgery: a systematic review and meta-analysis
The correlation of intraoperative oliguria with acute kidney injury after noncardiac surgery: a systematic review and meta-analysis Open
Background: Acute kidney injury (AKI) occurs commonly after major surgery and is correlated with increased in-hospital morbidity and mortality. There is no consensus on whether intraoperative oliguria affects postoperative AKI. We conducte…
View article: Predicting the prognosis in patients with sepsis by a pyroptosis-related gene signature
Predicting the prognosis in patients with sepsis by a pyroptosis-related gene signature Open
Background Sepsis remains a life-threatening disease with a high mortality rate that causes millions of deaths worldwide every year. Many studies have suggested that pyroptosis plays an important role in the development and progression of …
View article: Noncoding RNAs: Novel Targets for Opioid Tolerance
Noncoding RNAs: Novel Targets for Opioid Tolerance Open
As a global health problem, chronic pain is one of the leading causes of disability, and it imposes a huge economic and public health burden on families and society. Opioids represent the cornerstone of analgesic drugs. However, opioid tol…
View article: Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain
Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain Open
Bone cancer pain (BCP) is one of the typical and distressing symptoms in cancer patients. Morphine is a widely used analgesic drug for BCP; however, long-term morphine administration will lead to analgesic tolerance. Our previous study ind…
View article: Identification and characterization of N6-methyladenosine circular RNAs in the spinal cord of morphine-tolerant rats
Identification and characterization of N6-methyladenosine circular RNAs in the spinal cord of morphine-tolerant rats Open
Morphine tolerance (MT) is a tricky problem, the mechanism of it is currently unknown. Circular RNAs (circRNAs) serve significant functions in the biological processes (BPs) of the central nervous system. N6-methyladenosine (m 6 A), as a k…
View article: Commentary: Lung Recruitment, Individualized PEEP, and Prone Position Ventilation for COVID-19-Associated Severe ARDS: A Single Center Observational Study
Commentary: Lung Recruitment, Individualized PEEP, and Prone Position Ventilation for COVID-19-Associated Severe ARDS: A Single Center Observational Study Open
GENERAL COMMENTARY article Front. Med., 24 May 2022Sec. Intensive Care Medicine and Anesthesiology https://doi.org/10.3389/fmed.2022.884942
View article: Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice
Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice Open
Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia. Vesicular glutamate transporter 2 (VGluT2) accumulates glutamate into syna…
View article: Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats
Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats Open
The parenchymal microglia possess different morphological characteristics in cerebral physiological and pathological conditions; thus, visualizing these cells is useful as a means of further investigating parenchymal microglial function. A…
View article: PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model
PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model Open
Background Previous studies have proved that peripheral nerve injury is involved in the pathogenesis of neuropathic pain (NP). The peripheral nerve injury primes spinal M1 microglia phenotype and produces pro-inflammatory cytokines, which …
View article: Identification of tRNA-derived small RNAs and their potential roles in the hippocampus of nicotine exposure rats
Identification of tRNA-derived small RNAs and their potential roles in the hippocampus of nicotine exposure rats Open
Nicotine use is highly prevalent and brings a huge burden on individuals, society, health-care systems and economic development. The existing mechanisms underlying nicotine’ actions can’t illuminate all basic and clinical problems thorough…
View article: Research progress in influence of perioperative hypotension on postoperative outcome of patients.
Research progress in influence of perioperative hypotension on postoperative outcome of patients. Open
With the advancement of disease treatments, the number of patients undergoing surgery worldwide is increasing. However, many patients still experience severe perioperative complications. Perioperative hypotension is one of the common side …
View article: Identification of tRNA-Derived Small RNAs and their Potential Roles in the Hippocampus of Nicotine Exposure Rats
Identification of tRNA-Derived Small RNAs and their Potential Roles in the Hippocampus of Nicotine Exposure Rats Open
Nicotine use is highly prevalent and brings a huge burden on individuals, society, health-care systems and economic development. The existing mechanisms underlying nicotine’ actions can’t illuminate all basic and clinical problems thorough…