Wanil Kim
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View article: Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons
Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons Open
Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a pivotal role in regulating brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system. The activation of transient receptor potential ank…
View article: The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis
The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis Open
The major function of primary order neurons in the arcuate nucleus of the hypothalamus is control of energy homeostasis. Among these neurons, proopiomelanocortin (POMC) neurons play a significant role in controlling anorexigenic feeding be…
View article: Comparative Morphometric and Histometric Evaluation of Power-Dependent Tissue Ablation Using Fractional Carbon Dioxide Laser
Comparative Morphometric and Histometric Evaluation of Power-Dependent Tissue Ablation Using Fractional Carbon Dioxide Laser Open
The 40 W fractional CO2 laser system offers enhanced precision, deeper dermal penetration, and reduced thermal diffusion compared with the 30 W, despite delivering equivalent total energy. These findings suggest that higher peak power sett…
View article: <i>Dendranthema boreale</i> (Makino) Ling ex Kitam. Flower Extract Ameliorates Oxidative Stress-Induced Cellular Damage in HaCaT Keratinocytes by Regulating MAPK Signaling
<i>Dendranthema boreale</i> (Makino) Ling ex Kitam. Flower Extract Ameliorates Oxidative Stress-Induced Cellular Damage in HaCaT Keratinocytes by Regulating MAPK Signaling Open
Oxidative stress plays a critical role in skin aging and in various dermatological disorders by promoting inflammation, apoptosis, and cellular dysfunction. Among reactive oxygen species (ROS), hydrogen peroxide (H2O2) readily penetrates c…
View article: The Role of SLPI Gene-Mediated Inflammation in Osteoarthritis
The Role of SLPI Gene-Mediated Inflammation in Osteoarthritis Open
Osteoarthritis (OA) is a degenerative disease of joint tissue characterized by the breaking down of cartilage and resulting changes in synovium and bone. Mechanics and biology interact in a feed-forward manner in that imbalanced joint load…
View article: Lactobacillus brevis-Derived Exosomes Enhance Skin Barrier Integrity by Upregulating Key Barrier-Related Proteins
Lactobacillus brevis-Derived Exosomes Enhance Skin Barrier Integrity by Upregulating Key Barrier-Related Proteins Open
These results suggest that LBDEs have potential in enhancing skin barrier function, as evidenced by increased expression of crucial barrier-related proteins in both in vitro and ex vivo models.
View article: Effects of Shampoo Containing Plantago asiatica L. on Hair Thickness, Density, and Shedding: A Double-Blind, Randomized, Placebo-Controlled Clinical Study
Effects of Shampoo Containing Plantago asiatica L. on Hair Thickness, Density, and Shedding: A Double-Blind, Randomized, Placebo-Controlled Clinical Study Open
This double-blind, randomized, placebo-controlled clinical study evaluated the efficacy of a shampoo containing Plantago asiatica L. on hair health in adults aged 20–60. Following a 4-week wash-out period, participants used either the test…
View article: Chlorogenic Acid Enhances Beta‐Lapachone‐Induced Cell Death by Suppressing Autophagy in NQO1‐Positive Cancer Cells
Chlorogenic Acid Enhances Beta‐Lapachone‐Induced Cell Death by Suppressing Autophagy in NQO1‐Positive Cancer Cells Open
Resistance to apoptosis‐inducing drugs frequently occurs in cancer cells, limiting their usefulness in ongoing cancer treatment. Despite ongoing efforts to overcome drug resistance, a definitive solution remains elusive. However, autophagy…
View article: Cereblon deficiency ameliorates carbon tetrachloride-induced acute hepatotoxicity in HepG2 cells by suppressing MAPK-mediated apoptosis
Cereblon deficiency ameliorates carbon tetrachloride-induced acute hepatotoxicity in HepG2 cells by suppressing MAPK-mediated apoptosis Open
The liver is vulnerable to various hepatotoxins, including carbon tetrachloride (CCl 4 ), which induces oxidative stress and apoptosis by producing reactive oxygen species (ROS) and activating the mitogen-activated protein kinase (MAPK) pa…
View article: Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells
Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells Open
Given that the skin is the largest tissue in the human body, performing external barrier functions with innate and adaptive immunity and undergoing substantial changes during aging, it is under investigation as a major target of various bi…
View article: Development of droplet digital PCR-based detection of bacterial pathogens in prosthetic joint infection: a preliminary study using a synthesized model plasmid
Development of droplet digital PCR-based detection of bacterial pathogens in prosthetic joint infection: a preliminary study using a synthesized model plasmid Open
Periprosthetic joint infection (PJI) can be diagnosed to characterize the microorganisms constituting a biofilm, which is an essential procedure for proper treatment. The gold standard method for detecting and identifying the causative mic…
View article: Manipulating RKIP reverses the metastatic potential of breast cancer cells
Manipulating RKIP reverses the metastatic potential of breast cancer cells Open
Breast cancer is a common tumor type among women, with a high fatality due to metastasis. Metastasis suppressors encode proteins that inhibit the metastatic cascade independent of the primary tumor growth. Raf kinase inhibitory protein (RK…
View article: Photoprotective Effect of Fermented and Aged Mountain-Cultivated Ginseng Sprout (Panax ginseng) on Ultraviolet Radiation-Induced Skin Aging in a Hairless Mouse Model
Photoprotective Effect of Fermented and Aged Mountain-Cultivated Ginseng Sprout (Panax ginseng) on Ultraviolet Radiation-Induced Skin Aging in a Hairless Mouse Model Open
Interest in foods that promote inner beauty increases with increases in exposure to ultraviolet (UV) rays and with improvements in quality of life. This study was performed to evaluate the efficacy of fermented and aged mountain-cultivated…
View article: Autophagy in Cell Survival and Death
Autophagy in Cell Survival and Death Open
Autophagy is a degradative process to remove damaged or unnecessary cellular components, and it has been implicated in many biological processes during cell survival and death [...]
View article: The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder
The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder Open
Circadian rhythm regulates physiological cycles of awareness and sleepiness. Melatonin production is primarily regulated by circadian regulation of gene expression and is involved in sleep homeostasis. If the circadian rhythm is abnormal, …
View article: Chrysanthemum boreale Makino Inhibits Oxidative Stress-Induced Neuronal Damage in Human Neuroblastoma SH-SY5Y Cells by Suppressing MAPK-Regulated Apoptosis
Chrysanthemum boreale Makino Inhibits Oxidative Stress-Induced Neuronal Damage in Human Neuroblastoma SH-SY5Y Cells by Suppressing MAPK-Regulated Apoptosis Open
Oxidative stress has been demonstrated to play a pivotal role in the pathological processes of many neurodegenerative diseases. In the present study, we demonstrated that Chrysanthemum boreale Makino extract (CBME) suppresses oxidative str…
View article: Investigation of an Axial Virtual Cathode Oscillator with an Open-Ended Coaxial Cathode
Investigation of an Axial Virtual Cathode Oscillator with an Open-Ended Coaxial Cathode Open
A cathode with an open-ended coaxial structure is experimentally investigated using an axial virtual cathode oscillator (vircator). To enhance the microwave power output, an open-ended coaxial cathode is installed in the axial vircator. Th…
View article: Compressive femoral neuropathy caused by anticoagulant therapy induced retroperitoneal hematoma
Compressive femoral neuropathy caused by anticoagulant therapy induced retroperitoneal hematoma Open
Rationale: Spontaneous retroperitoneal hematomas due to anticoagulant therapy rarely occur. Retroperitoneal hematomas can cause severe pain in the groin, quadriceps femoris muscle weakness, hemodynamic instability, and abdominal distension…
View article: Complex regional pain syndrome type II caused by iatrogenic lateral dorsal cutaneous nerve injury
Complex regional pain syndrome type II caused by iatrogenic lateral dorsal cutaneous nerve injury Open
Rationale: Complex regional pain syndrome (CRPS) is a painful condition classified as type I or II depending on the absence or presence of nerve injury, respectively. Injury to the lateral dorsal cutaneous nerve (LDCN), a branch of the sur…
View article: A Functional Network Model of the Metastasis Suppressor PEBP1/RKIP and Its Regulators in Breast Cancer Cells
A Functional Network Model of the Metastasis Suppressor PEBP1/RKIP and Its Regulators in Breast Cancer Cells Open
Drug screening strategies focus on quantifying the phenotypic effects of different compounds on biological systems. High-throughput technologies have the potential to understand further the mechanisms by which these drugs produce the desir…
View article: Regulation of Gene Expression by Telomere Position Effect
Regulation of Gene Expression by Telomere Position Effect Open
Many diseases that involve malignant tumors in the elderly affect the quality of human life; therefore, the relationship between aging and pathogenesis in geriatric diseases must be under-stood to develop appropriate treatments for these d…
View article: Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells
Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells Open
Glioblastoma is an actively growing and aggressive brain tumor with a high propensity of recurrence. Although the surgical removal of tumor mass is the primary therapeutic option against glioblastoma, supportive pharmacotherapy is highly e…
View article: Chronic Alcohol Exposure of Cells Using Controlled Alcohol-Releasing Capillaries
Chronic Alcohol Exposure of Cells Using Controlled Alcohol-Releasing Capillaries Open
Alcohol is one of the main causes of liver diseases such as fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis. To reproduce the conditions of alcohol-induced liver diseases and to identify the disease…
View article: RNA-Binding Proteins and the Complex Pathophysiology of ALS
RNA-Binding Proteins and the Complex Pathophysiology of ALS Open
Genetic analyses of patients with amyotrophic lateral sclerosis (ALS) have identified disease-causing mutations and accelerated the unveiling of complex molecular pathogenic mechanisms, which may be important for understanding the disease …
View article: Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing
Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing Open
Inspired by the effectiveness of low-intensity ultrasound on tissue regeneration, we investigated the potential effect of short-term high-intensity ultrasound treatment for acceleration of wound healing in an in vitro wound model and derma…