Explanipedia

Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision Open

Ming Cai, Keren Cai, Zhiyi Wei, Jing Zhou, Jiayi Shu , et al. · 2025

Cerebrovascular dysfunctions, encompassing changes in cerebrovascular microstructure, blood-brain barrier (BBB) integrity, cerebrovascular reactivity, and cerebral blood flow (CBF), accelerate the pathological progression of Alzheimer's di…

Real-world analysis of characteristics and guideline adherence of antiplatelet drugs prescriptions among patients with coronary artery disease and its comorbidities: a cross-sectional study. Open

Ting Lu, Zhe Yang, Peipei Zhang, Haiyan Zhu, Qiao Chu , et al. · 2025

The proportion of APD prescriptions for CAD outpatients was lower than expected. The rationality analysis revealed that both CCS and recent ACS patients showed suboptimal guideline adherence in real-world APD prescriptions, especially for …

Wearable Devices as Tools for Better Hypertension Management in Elderly Patients Open

Yangui Wang, Jinghua Tan, Jin Zhao, Tao Wang, Tingting Ma , et al. · 2025

BACKGROUND Hypertension is a growing global health concern, particularly among the elderly, and is a significant contributor to cardiovascular and cerebrovascular diseases. Managing hypertension in elderly patients is particularly challeng…

Study on Energy Consumption Reduction for Liquefied Natural Gas Gasification System Using Warm Seawater Open

YAN XU, Wanju Sun, Siyuan Cheng · 2025

Study on Carbon Emission Reduction for Liquefied Natural Gas Gasification System Using Warm Seawater Open

Wanju Sun, Yan Xu, Siyuan Cheng · 2025

Energy Consumption Optimization Analysis of Warm Seawater Natural Gas Gasification System Open

YAN XU, Tao Luan, Pingbing Zuo, Zheng Cai, Wanju Sun , et al. · 2025

Elastocaloric effect and cooling performance of NiTi sheets in a continuous rotating bending elastocaloric cooler Open

Siyuan Cheng, Wanju Sun, Xueshi Li, Jiongjiong Zhang · 2024

Elastocaloric cooling technology has the prospect of becoming a commercialized green alternative to current vapor-compression technology, and the systematic characterization of the elastocaloric effect and microstructure has become increas…

Multistructured hydrogel promotes nerve regeneration Open

Ning Zhu, Yaping Zhuang, Wanju Sun, Juan Wang, Fan Wang , et al. · 2024

Hydrogels have emerged as promising biomaterials for nerve regeneration due to their adjustable properties, structural resemblance to the extracellular matrix, and ability to promote cell adhesion and proliferation. This comprehensive revi…

Biomechanical Role of Bone Grafting for Calcaneal Fracture Fixation in the Presence of Bone Defect: A Finite Element Analysis Open

Zhihao Su, Ming Ding, Ning Zhu, James Chung‐Wai Cheung, Duo Wai‐Chi Wong , et al. · 2023

Background The purpose of this study was to compare the biomechanical stress and stability of calcaneal fixations with and without bone defect, before and after bone grafting, through a computational approach. Methods A finite element mode…

Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy Open

Ping Zheng, Ning Zhang, Dabin Ren, Yu Cong, Bin Zhao , et al. · 2023

Introduction Post-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T ce…

Do medical alliances truly work? Perspectives on health service utilisation among outpatients with chronic diseases in Shanghai, China Open

Wanju Sun, Haiyan Zhu, Linyi Zhang, Zhaoxin Wang, Luo Li , et al. · 2023

Background To achieve proper health utilisation among various health institutions and improve primary care capacity, China implemented medical alliance (MA) reform as part of healthcare reforms in 2009. With chronic disease management as t…

Understanding the Contribution of Lactate Metabolism in Cancer Progress: A Perspective from Isomers Open

Ming Cai, Jian Wan, Keren Cai, Haihan Song, Yujiao Wang , et al. · 2022

Lactate mediates multiple cell-intrinsic effects in cancer metabolism in terms of development, maintenance, and metastasis and is often correlated with poor prognosis. Its functions are undertaken as an energy source for neighboring carcin…

Presence of and hospital resource utilization for comorbid ventricular septal defects in pediatric patients: A cross-sectional study in Shanghai, China Open

Xiaoxu Huang, Peipei Zhang, Yan Yang, Sheng Lu, Ning Chen , et al. · 2022

Objectives To describe the characteristics of high-incidence comorbidity combinations of pediatric ventricular septal defect (VSD) among inpatients in Shanghai, China. Methods In total, 5,994 inpatient pediatric VSD cases with ICD-10-based…

Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule Open

Ming Cai, Hongbiao Wang, Haihan Song, Ruoyu Yang, Liyan Wang , et al. · 2022

Research to date has provided novel insights into lactate's positive role in multiple brain functions and several brain diseases. Although notable controversies and discrepancies remain, the neurobiological role and the metabolic mechanism…

Biomechanical Analysis of a Novel Double-Point Fixation Method for Displaced Intra-Articular Calcaneal Fractures Open

Miko Lin Lv, Ming Ni, Wanju Sun, Duo Wai‐Chi Wong, Shuren Zhou , et al. · 2022

The development of minimally invasive procedures and implant materials has improved the fixation strength of implants and is less traumatic in surgery. The purpose of this study was to propose a novel “double-point fixation” for calcaneal …

Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression Open

Jian Wan, Shunfang Liu, Wanju Sun, Haiyi Yu, Wenlian Tang , et al. · 2021

Fracture mapping of complex intra-articular calcaneal fractures Open

Ming Ni, Miko Lin Lv, Wanju Sun, Yingqi Zhang, Jiong Mei , et al. · 2021

Calcaneal fracture lines follow characteristic patterns, which are closely related to the bone structure and fracture mechanism. These fracture patterns will aid clinicians choose surgical approach and fixations in the treatment of calcane…

[Research progress of medial buttress plate assisted fixation for femoral neck fractures in young adults]. Open

Ming Ni, Wanju Sun, Ye Ye · 2020

Medial buttress plate assisted fixation can achieve good effectiveness for femoral neck fractures in young adults. However, due to the preliminary application, its indications, fixation implants, and long-term effectiveness need to be furt…

Biomechanical analysis of minimally invasive crossing screw fixation for calcaneal fractures: Implications to early weight-bearing rehabilitation Open

Haowei Zhang, Miko Lin Lv, Liu Yin, Wanju Sun, Wenxin Niu , et al. · 2020

Clinical Characteristics and Eosinophils in Young SARS-CoV-2-Positive Chinese Travelers Returning to Shanghai Open

Juan Yang, Xiaohui Zhao, Xueyuan Liu, Wanju Sun, Zhou Long-zhu , et al. · 2020

Background: The COVID-19 outbreak, which was first reported in Wuhan, China, in December 2019, began to spread throughout the world, and now involves over 200 countries. Methods: A total of 37 overseas young and middle-aged p…

Computational modelling of foot orthosis for midfoot arthritis: a Taguchi approach for design optimization Open

Haowei Zhang, Miko Lin Lv, Junyan Yang, Wenxin Niu, James Chung‐Wai Cheung , et al. · 2020

Purpose: Evaluation of the internal biomechanics of the foot-and-ankle complex is challenging for the prescription of orthosis particularly for midfoot arthritis patients in which the joint condition is crucial. Methods: Using computationa…

Adipocyte-derived Periostin mediates glucocorticoid-induced hepatosteatosis in mice Open

Jian Wan, Yi Shan, Xi Song, Song Chen, Xinyuan Lu , et al. · 2019

Our findings provided a novel insight that GCs could promote liver steatosis through integrative organ crosstalk mediated by white fat-secreted Periostin. These results establish Periostin as an endocrine factor with therapeutic potential …

Adipocyte-Derived Periostin Mediates Glucocorticoid-Induced Hepatosteatosis in Mice Open

Jian Wan, Yi Shan, Xi Song, Song Chen, Xinyuan Lu , et al. · 2019

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury Open

Qiang Li, Shane Gao, Zhanrong Kang, Meiyan Zhang, Xin Zhao , et al. · 2018

The spinal cord is extremely vulnerable to ischemia-reperfusion (I/R) injury, and the mitochondrion is the most crucial interventional target. Rapamycin can promote autophagy and exert neuroprotective effects in several diseases of the cen…

Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes Open

Liang‐Bin Xiong, Hao-Hao Liu, Liqin Xu, Wanju Sun, Feng‐Qing Wang , et al. · 2017

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